I just came off Effexor slowly. and weighed 230, before I strted I weighed 210.now my weight is 248, and I started taking Zoloft one week ago. will the weight stay at. 248, or taper off slowly.i wonder once the Effexor is out of my system. cause it changes, your metabolism, to slow down. and it stores the food u eat as fat around your midsection.MY name is Kevin.