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What happens when you mix tramadol with muscle relaxer?

Answers (6)

4 Oct 2013

It would not be a good idea.

Flexeril (cyclobenzaprine) is a muscle relaxant and here is the interaction result:

Interactions between your selected drugs


4 Oct 2013

Not allot. I take tramadol and tizanidine every day.

MacIntosh12 5 Oct 2013

Hi km and DZ, I've also taken them together... many times! Had NO idea they interacted so badly (for folks who are not tolerant of both meds.)

masso 5 Oct 2013

Hello to you and evey Lady present.-
Mac,i Hope you are well in every aspect of you life... Lara...

4 Oct 2013

People use muscle relaxants and pain meds together every day. Taking them together helps each one work better (potentiates) but it can also increase side effects like sedation, drowsiness, CNS (Central Nervous System) depression, etc. They should be used together judiciously and never use both plus alcohol.


4 Oct 2013

Hello julieredose. Sedation, fatigue, cognitive impairment, motor skills etc. Regards pledge

5 Oct 2013

Hi, different types of muscle relaxants show different results. For example Tramadol taken with Robaxin come up with a moderate interaction risk:,1588-964
Whereas Tramadol taken with Quinine, show no interaction risks:,2221-0
And as Masso has already commented, Tramadol taken with Flexeril show a major interaction risk:,758-386 It really depends on the individual medication, not the class - muscle relaxants

masso 5 Oct 2013

Great answer Delila.

Delila 5 Oct 2013

Thank you : )

17 Jul 2015

Not sure for everyone as each person can react differently. I only speak from personal experience. I have taken both together for almost 20 years but just as needed. The biggest issue with many ppl is they think they have to take them every day 3 times a day, pain or not. I only take them when I really hurt. I have trained myself to sleep through the painr but tramadol and a muscle relaxer be a God send. I stick with my rheumatologist and avoid pain specialists.One caused me to go through out patient detox.

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