Have any of you experienced muscle pain since starting Praluent?

Yes. Couldn’t take statins, been on Praluent for a year. Numbers are great, but within the past few weeks, I’ve been experiencing lower back pain, calf soreness, muscle weakness. I’ve had a previous stroke, but perhaps I’ll just continue with my low dose aspirin.

High cholesterol runs in my family, no heart disease. Been on Praluent for 18 months now. It had lowered my chances, but I can hardly move. My lower back aches so bad as well as my legs. I take Tylenol, but worried about its long term use. Thinking of stopping Praluent. My quality of life has very much suffered Has anyone experienced this type of debilitating symptoms???

I took Praluent for a year and did not notice any side effects. I did switch to the twice a year shot Leqvio a year ago with no side effects. I am a 76 year old man. Both are ok with me. No pains.

Yes. Leg cramps and deep seated pain in hip. Different than pain from statins that actually caused more leg cramps and my hands to tingle and fall asleep at night as well as swell. All of these drugs so far raise my liver enzymes above normal

I’ve been on a low dose statin for several years and about a year on Praluent. I’ve had an amazing reduction in my LDL and triglycerides numbers but over the past few months I’ve started having severe leg cramps along with some hip pain. I do plan to talk to my Dr about this. I’m disappointed that I’m having problems and it does cause a dilemma in dealing with heart disease vs muscle pain…

I have been taking this for a year 75mg twice a month. Statins nearly crippled me that is why I am on Praluent. For the first 3 months it still hurt to walk but after 6 months no pain and LDL consistently down at 70 with lower triglycerides. I do not have genetic hyper just family history of early cardiac death. I think some of you on Statins and Praluent may be attributing the leg pain and cramps to Praluent when It may be the Statins. It took 6 months for the statin to be out of my system and there was no difference between combo and praluent only in cholesterol lowering. You may want to talk to a doc about trying to come off the statin

I can't answer your question about Praluent and muscle pain specifically because I am now taking Repatha in addition to a low doses of Lipitor and Zetia. However, because I have a long history of high cholesterol and years of statin use and have experienced mild to severe muscle pain over the years, I wanted to share what has been helpful to me in the last few years:
1. Plant sterols to lower cholesterol. (I take NatureMade CholestOff but there are other options.)
Phytosterols were recommended to me by a lipid clinic because they have been shown to lower cholesterol by about 10% in addition to statins and PCSK9 benefits.
2. OTC magnesium glycinate
3. CoQ10
Be sure to check with your health care provider as there isn't agreement about the benefit of supplements but I wanted to share my experience as muscle pain often leads us to discontinue lipid lowering prescription options when they have demonstrated cholesterol lowering benefits.

I have been on repatha for 4 months.
Did wonders for lipids.
However now muscle spasms and leg cramps are horrible
Up all night.
Anyone have similar?
Thinking about changing to praulent.
Any help out there?

I’m on Repatha. I couldn’t take the statins. The day after my first and second injection I had some muscle pain. Now I take 2 Aleve at the same time of my injections and I have no muscle pain at all.

I started taking Praluent 75mg injections Sept. 1, 2018. So far no side effects. I'm on my 14th injection taken every other Friday. I also take 10 mg. Atorvastatin. A year ago my bad Ldl was 200. Today my bad Ldl is 40. A big drop. I'm a 72 year old man in good health. The highest dose statin I can stand is 10mg. Any higher brings on severe muscle pain. I'm waiting for Bempedoic pills to come on the market to lower my Ldl another 20% with no side effects.

I started the Praluent 75mg injections in my legs on Sept. 7, 2018. I'm on my 13th injection. So far I don't notice any side effects. I do get muscle pain from statins. I take an over the counter pain pill to make the pain go away. Statins reduced my LDL from 200 to 80mg. Adding the Praluent lowered my LDL down from 80mg to 40 LDL very quickly. I'am very happy with the results and also the 60% price drop announced by the manufacturer coming in March 2019.

I am in my 3rd year of Praluent. It's nothing less than a miracle drug for me. It dropped my cholesterol from a start of around 250 to 107 on last test. I only inject once every three weeks instead of two. I'm going to a once a month injection starting with my next injection. 75mg.

I took it after trying about 4 different statins with horrible muscle cramping. Mainly in the legs and calf's. Absolutely no side effects with Praluent. I hope it works as well for you.