I have been taking it close to fifteen years. I have developed First Degree AV block & Right Bundle Branch Block. Extremely tired all the time, Moody, nervous, no get up & go. Have gained weight, feet & legs swell, my right hand & head shakes. my liver showed "enlarged" in recent test. My hips & legs ache, can barely walk when getting up. I think all this could be caused by Cardizem & would like to stop taking it. My Dr. says he doesn't know what will happen if I stop. I also take Synthroid 25 mg & Armour 75mg, plus the IC Diltiazem (cardizem) 24 hr.ER 120mg. 1 ea. a day (female, age 70)