10 Sep 2012
kaismama is right! Here is the official info on this, hope this helps you...
naproxen ↔ warfarin
Applies to: Aleve (naproxen), warfarin
GENERALLY AVOID: Nonsteroidal anti-inflammatory drugs (NSAIDs) may potentiate the hypoprothrombinemic effect and bleeding risk associated with oral anticoagulants. In a one-year observational study of a population of coumarin users, the relative risk of bleeding complications due to concomitant NSAID use was 5.8 compared to coumarin use alone. Some investigators suggest that the risk of hemorrhagic peptic ulcers in particular may be substantially increased, especially in elderly or debilitated patients. A retrospective epidemiologic study of patients aged 65 years or older reported a nearly 13-fold increase in the risk of developing hemorrhagic peptic ulcer disease in concurrent users of oral anticoagulants and NSAIDs compared with nonusers of either drug. Fatalities have been reported. The pharmacologic effects of NSAIDs that contribute to this interaction include gastrointestinal irritation, prolongation of prothrombin time, and inhibition of platelet adhesion and aggregation. In addition, various NSAIDs have also been shown to alter the pharmacokinetics of warfarin and other oral anticoagulants, resulting in increased INR or prothrombin time. However, some studies failed to demonstrate any evidence of an interaction.
MANAGEMENT: NSAIDs should be administered with oral anticoagulants only if benefit outweighs risk. The INR should be checked frequently and oral anticoagulant dosage adjusted accordingly, particularly following initiation or discontinuation of NSAIDs in patients who are stabilized on their anticoagulant regimen. Patients should be advised to promptly report any signs of unusual bleeding or bruising to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, red or brown urine, or red or black stools. Salicylates (except aspirin) appear to have less effect on coagulation and may be preferable in patients treated with oral anticoagulants. Nevertheless, caution is advised and close monitoring for gastrointestinal bleeding is recommended, particularly in elderly or debilitated patients
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
I have been taking Warfarin about nine months, these complaints continue. Daily activities wear me out quickly. Any help for this? Last month I ...
2 answers • 5 Aug 2011
... experiencing double vision, blurred vision and seeing something in distance that is not really there. Could this be a longer term side-effect of ...
1 answer • 3 Mar 2012
I have inflamaton in colon of unknown origin. alergine to NSAI probable took lots of aleve for failed root canal. been sick over three months. ...
1 answer • 5 May 2012
87 year old uncle on warfarin for 10 years and his sight has detererited even with his up to date glasses also he sees black floaters( weblike)
2 answers • 19 Jan 2014