I take Synthroid everyday because I have an underactive thyroid problem, and I also have a GERD problem which I take esomeprazole every day. What is really the best timing to take these two medications? I am concerned about esomeprazole depleting the acid in my body for the Synthroid to work effectively. I would also like to consider taking the esomeprazole every other day or slowly weaning off it it but once the GERD acts up I have to take it again. What should I do in this situation?