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Related terms: Complex Partial Seizure, Fits, Absence Seizure

Two Drugs Work Equally Well for Epileptic Seizures in Kids: Study

Posted 22 Apr 2014 by Drugs.com

TUESDAY, April 22, 2014 – Researchers comparing two drugs used to treat epileptic seizures in children – lorazepam (Ativan) and diazepam (Valium) – found no difference between them in safety or effectiveness. Although previous studies gave the edge to Ativan, Dr. James Chamberlain, lead researcher for the new study, gave several reasons why Valium might be as good or better. "Unexpectedly, Ativan is not superior to Valium for treating pediatric seizures. It's been dogma in medicine that Ativan is better than Valium, but this study shows that they are just about equal," said Chamberlain, division chief of emergency medicine and trauma services at Children's National Medical Center in Washington, D.C. Since Valium does not have to be refrigerated, it might be a better choice for paramedics who treat seizure patients before they arrive at a hospital, he said. "They can start Valium ... Read more

Related support groups: Seizures, Valium, Ativan, Lorazepam, Epilepsy, Diazepam, Diastat, Valrelease, Dizac, Diastat AcuDial, Diazepam Intensol, Lorazepam Intensol, Zetran, Diastat Pediatric

Upsher-Smith Receives FDA Approval for Qudexy XR (topiramate) Extended-Release Capsules

Posted 13 Mar 2014 by Drugs.com

Maple Grove, MN – March 12, 2014 – Upsher-Smith Laboratories, Inc. (Upsher-Smith), today announced it received approval on March 11, 2014 from the U.S. Food and Drug Administration (FDA) for Qudexy XR (topiramate) extended-release capsules, a once-daily, broad-spectrum antiepileptic drug specifically engineered to deliver a smooth pharmacokinetic (PK) profile. Qudexy XR is indicated as initial monotherapy in patients 10 years of age and older with partial-onset seizures (POS) or primary generalized tonic clonic seizures. It is also approved as adjunctive therapy in patients 2 years of age and older with POS, primary generalized tonic-clonic seizures and seizures associated with Lennox-Gastaut syndrome. Qudexy XR will be available to patients in the second quarter of 2014. As many as two out of three patients treated for epilepsy have seizures that are refractory to therapy, either bec ... Read more

Related support groups: Seizures, Topiramate

Fever-Related Seizures in Kids Eased by Epilepsy Drug: Study

Posted 6 Feb 2014 by Drugs.com

THURSDAY, Feb. 6, 2014 – Early treatment with antiepileptic drugs reduces the length of fever-related seizures in children, according to a new study. Published Feb. 6 in the journal Epilepsia, the study also found that a standard emergency medical services treatment guideline for prolonged fever-related seizures is needed in the United States. Most fever-related seizures, also called febrile seizures, are brief, but up to 10 percent can last more than 30 minutes. These prolonged seizures can put children at risk for short- and long-term complications, including developing epilepsy, according to a journal news release. The new study included nearly 200 children, aged 1 month to 6 years, who had one seizure or a group of seizures that lasted more than 30 minutes. The researchers examined the connection between time to treatment and length of the seizure. About 90 percent of the children ... Read more

Related support groups: Seizures

Study Weighs Safety of Epilepsy Drugs in Pregnancy

Posted 8 Jan 2014 by Drugs.com

WEDNESDAY, Jan. 8, 2014 – There's long been concern that certain drugs taken to control seizures might be unsafe for use by pregnant women, due to potential effects on the fetus. Now, new British research suggests that the drug levetiracetam does not pose a major risk to the neurological development of the fetus, although there's more evidence that another drug – valproate – may cause some problems. "These results are heartening, as the use of levetiracetam has increased in recent years, but there has been limited information on its effect on the thinking, movement and language abilities of children," study author Rebekah Shallcross of the University of Liverpool said in a news release from the American Academy of Neurology. "This is the first study to look at the effects of levetiracetam, and further research is needed before we can be certain there are no associations," Shallcross ... Read more

Related support groups: Seizures, Epilepsy, Keppra, Levetiracetam, Keppra XR

FDA Approves Aptiom to Treat Seizures in Adults

Posted 10 Nov 2013 by Drugs.com

November 8, 2013 – The U.S. Food and Drug Administration today approved Aptiom (eslicarbazepine acetate) as an add-on medication to treat seizures associated with epilepsy. Epilepsy is a brain disorder caused by abnormal or excessive activity in the brain’s nerve cells. Approximately 200,000 new cases of seizures and epilepsy occur in the United States each year. Aptiom is approved for the treatment of partial seizures, the most common type of seizure seen in people with epilepsy. Seizures can cause a wide range of symptoms, including repetitive limb movements, unusual behavior and generalized convulsions with loss of consciousness. Seizures can have serious consequences, including injury and death. “Some patients with epilepsy do not achieve satisfactory seizure control from existing treatments,” said Eric Bastings, M.D., acting director of the Division of Neurology Products in t ... Read more

Related support groups: Seizures, Epilepsy

FDA Medwatch Alert: Potiga (Ezogabine): Drug Safety Communication - Linked To Retinal Abnormalities And Blue Skin Discoloration

Posted 4 Nov 2013 by Drugs.com

UPDATED 11/01/2013:  FDA approved changes to the drug label, underscoring risks of abnormalities to the retina in the eye, potential vision loss, and skin discoloration, all of which may become permanent. The revised label includes a new boxed warning, because of the risk of abnormalities to the retina. FDA advises that Potiga use be limited to patients who have not responded adequately to several alternative therapies to decrease the frequency of seizures, or epilepsy, and for whom the benefits of treatment outweigh the risks. AUDIENCE: Health Professional, Neurology, Patient ISSUE: FDA is warning the public that the anti-seizure medication Potiga (Ezogabine) can cause blue skin discoloration and eye abnormalities characterized by pigment changes in the retina. FDA does not currently know if these changes are reversible. FDA is working with the manufacturer to gather and evaluate all ... Read more

Related support groups: Seizures, Epilepsy, Potiga

Epilepsy Drugs in Pregnancy May Affect Infants' Fine Motor Skills

Posted 25 Sep 2013 by Drugs.com

WEDNESDAY, Sept. 25 – Young children exposed to epilepsy drugs in the womb are at increased risk of having impaired fine motor skills, according to a new study. Exposure to the drugs in breast milk, however, does not appear to pose a threat. Researchers looked at data collected from Norwegian mothers about their children's language, behavior, and motor and social skills at the ages of 6 months, 18 months and 36 months. The women also provided information on breast-feeding during the first year for the study, which was published online Sept. 23 in the journal JAMA Neurology. Of the children in the study, 223 were exposed to one or more epilepsy drugs in the womb. At age 6 months, 11.5 percent of infants whose mothers took epilepsy drugs during pregnancy had impaired fine motor skills (which involve small muscle movements) compared with less than 5 percent of those who were not exposed ... Read more

Related support groups: Seizures, Klonopin, Lyrica, Clonazepam, Valium, Ativan, Lamictal, Topamax, Depakote, Lorazepam, Epilepsy, Diazepam, Keppra, Tegretol, Lamotrigine, Dilantin, Trileptal, Topiramate, Pregabalin, Carbamazepine

Mental Ills in Kids With Epilepsy May Depend on Seizure Location

Posted 29 May 2013 by Drugs.com

WEDNESDAY, May 29 – Depression and behavioral problems are common among children and teens with a type of epilepsy known as temporal lobe epilepsy, according to a new study. Seizures involving the temporal lobe of the brain are associated with significant psychiatric problems, the researchers found. Because of this, psychiatric evaluations are important for children with epilepsy, especially those who don't respond to anti-seizure medications and need surgery for their condition, the study authors pointed out in the report published online this month in the journal Epilepsia. "Our research examined whether psychiatric illness was more prominent in children who were unresponsive to anti-seizure medications and had seizures in the temporal lobe versus elsewhere in the brain," study lead author, Dr. Jay Salpekar of Children's National Medical Center in Washington, D.C., said in a journal ... Read more

Related support groups: Depression, Seizures, Epilepsy

FDA Medwatch Alert: Valproate Anti-Seizure Products: Drug Safety Communication - Contraindicated for Pregnant Women for Prevention of Migraine Headaches

Posted 6 May 2013 by Drugs.com

Including valproate sodium (Depacon), divalproex sodium (Depakote, Depakote CP, and Depakote ER), valproic acid (Depakene and Stavzor), and their generics ISSUE: FDA is advising health care professionals and women that the anti-seizure medication valproate sodium and related products, valproic acid and divalproex sodium, are contraindicated and should not be taken by pregnant women for the prevention of migraine headaches. Based on information from a recent study, there is evidence that these medications can cause decreased IQ scores in children whose mothers took them while pregnant. Stronger warnings about use during pregnancy will be added to the drug labels, and valproate’s pregnancy category for migraine use will be changed from "D" (the potential benefit of the drug in pregnant women may be acceptable despite its potential risks) to "X" (the risk of use in pregnant women clearly o ... Read more

Related support groups: Migraine, Seizures, Depakote, Migraine Prevention, Depakote ER, Migraine Prophylaxis, Divalproex Sodium, Valproic Acid, Depakote Sprinkles, Depakene, Stavzor, Depacon

FDA Warns Pregnant Women About Migraine Drugs

Posted 6 May 2013 by Drugs.com

MONDAY, May 6 – Pregnant women who struggle with migraine headaches should never use medicines containing the ingredient valproate because they can lower the IQ scores of their children, the U.S. Food and Drug Administration said Monday. The new warning will be included on the labels of medicines that contain valproate. These medicines already carry a boxed warning about fetal risk, including birth defects. Valproate products include valproate sodium (Depacon); divalproex sodium (Depakote, Depakote CP, and Depakote ER); valproic acid (Depakene and Stavzor); and their generic versions. "Valproate medications should never be used in pregnant women for the prevention of migraine headaches because we have even more data now that show the risks to the children outweigh any treatment benefits for this use," Dr. Russell Katz, director of the division of neurology products in the FDA's Center ... Read more

Related support groups: Migraine, Seizures, Valproic Acid, Depakene, Stavzor, Depacon

Implanted Device May Predict Epilepsy Seizures, Study Suggests

Posted 2 May 2013 by Drugs.com

THURSDAY, May 2 – An implanted device that monitors brain activity may offer a way to predict seizures in people with uncontrolled epilepsy, a small pilot study suggests. The findings, reported online May 2 in the journal Lancet Neurology, are based on only 15 patients, and the device worked far better in some than others. But experts said the results are promising, and should prompt further studies. "We just wanted to see if this is feasible, and this study shows that it is," said lead researcher Dr. Mark Cook, of the University of Melbourne and St. Vincent's Hospital in Australia. The prospect of being able to predict seizures is "very exciting," he said, in part because it's the uncertainty of the disorder that can dim people's quality of life. If people know a seizure is coming, Cook said, they can avoid driving or swimming that day, for example. They might also be able to adjust ... Read more

Related support groups: Seizures, Epilepsy

FDA Medwatch Alert: Potiga (Ezogabine): Drug Safety Communication - Linked To Retinal Abnormalities And Blue Skin Discoloration

Posted 27 Apr 2013 by Drugs.com

ISSUE: FDA is warning the public that the anti-seizure medication Potiga (Ezogabine) can cause blue skin discoloration and eye abnormalities characterized by pigment changes in the retina. FDA does not currently know if these changes are reversible. FDA is working with the manufacturer to gather and evaluate all available information to better understand these events. FDA will update the public when more information is available. BACKGROUND: Potiga is approved as adjunctive (added on to other anti-seizure medications) treatment of partial-onset seizures in adult patients 18 years and older. The skin discoloration in the reported cases appeared as blue pigmentation, predominantly on or around the lips or in the nail beds of the fingers or toes, but more widespread involvement of the face and legs has also been reported. Scleral and conjunctival discoloration, on the white of the eye and ... Read more

Related support groups: Seizures, Seizure Prevention, Seizure Prophylaxis, Potiga, Ezogabine

Tapeworm-Linked Seizures May Be Rising in U.S., Doctors Say

Posted 8 Apr 2013 by Drugs.com

MONDAY, April 8 – Tapeworm infection in the brain that can trigger seizures is a growing health concern, doctors say. But the infection, which leads to swelling in the brain, is usually treatable with medication, according to a leading association of neurologists. Estimated cases of neurocysticercosis, as the tapeworm infection is called, range from 40,000 to 160,000 each year in the United States, said Dr. Peter Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine in Houston. "It's been around a long time, affecting people living in severe poverty, but the disease is not well-studied or understood," Hotez said. Texas is one area of the country with many cases. "The disease has now become a leading cause of epilepsy in Houston," Hotez said. "Every [week], we have patients come into our tropical medicine clinic with it." Concerns about an apparent ... Read more

Related support groups: Seizures, Neurocysticercosis

Lengthy Seizures May Delay Mental Development, Study Suggests

Posted 8 Apr 2013 by Drugs.com

MONDAY, April 8 – Delays in mental development are detectable in children within six weeks after they have a seizure that lasts more than 30 minutes, and these impairments are still present a year later, a new study finds. British researchers looked at 54 children, ages 1 to 42 months, who had at least one of these long seizures, called convulsive status epilepticus (CSE). Some of them had seizures with fever and some without fever. The children were assessed within six weeks of the seizure and again after one year. They were compared to children who had not suffered seizures. The findings suggest that convulsive status epilepticus is linked to neurodevelopmental delays within six weeks of the seizure, and that these impairments are still present after one year, according to the study published April 8 in the journal Epilepsia. "The fact that neurodevelopmental impairments are still ... Read more

Related support groups: Seizures

Study Supports Link Between Stress, Epileptic Seizures

Posted 4 Dec 2012 by Drugs.com

TUESDAY, Dec. 4 – Scientists have long thought that stress plays a role in epileptic seizures, and new evidence suggests that epilepsy patients who believe this is the case experience a different brain response when faced with a nerve-wracking situation. Researchers from the University of Cincinnati performed functional MRI brain scans during a stressful math exercise on 16 epilepsy patients who pegged stress as a factor in their seizure control and seven patients who did not. While both groups performed similarly on the test, those who perceived stress to have an impact on their epilepsy showed greater brain activation than the others during intimidating parts of the test. "One of the things we often hear is that a lot of epilepsy patients feel their seizures are affected by stress . . . but no one had really looked at their [brain response] or other elements of their physiological ... Read more

Related support groups: Anxiety and Stress, Seizures, Epilepsy

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