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Rheumatoid Arthritis News

Related terms: Arthritis, Arthritis, Rheumatoid, RA, Rheumatoid, Inflamed Joints

Inflectra Approved as 'Biosimilar' to Remicade

Posted 7 Apr 2016 by Drugs.com

WEDNESDAY, April 6, 2016 – The U.S. Food and Drug Administration has approved its second-ever "biosimilar" drug, Inflectra, for adults with Crohn's disease, rheumatoid arthritis or chronic plaque psoriasis, among other prescribed uses. In a media release, the agency said Inflectra was biosimilar to Janssen Biotech's Remicade (infliximab), first licensed in 1998. A biosimilar drug is sanctioned based on its maker's ability to show that it is "highly similar" to an already-approved biological drug that is generally derived from a living organism, such as a person, animal, microorganism or yeast, the FDA said. The maker of a biosimilar drug also must prove that the product has no "clinically meaningful difference" in safety and effectiveness from the original drug, and that the newer product has only "minor differences in clinically inactive components" from the original. Inflectra's most ... Read more

Related support groups: Rheumatoid Arthritis, Psoriasis, Crohn's Disease, Remicade, Ulcerative Colitis, Psoriatic Arthritis, Ankylosing Spondylitis, Crohn's Disease - Maintenance, Ulcerative Colitis - Active, Plaque Psoriasis, Crohn's Disease - Acute, Ulcerative Colitis - Maintenance, Infliximab, Inflectra

FDA Approves Inflectra (infliximab-dyyb) a Biosimilar to Remicade

Posted 7 Apr 2016 by Drugs.com

April 5, 2016 – The U.S. Food and Drug Administration today approved Inflectra (infliximab-dyyb) for multiple indications. Inflectra is administered by intravenous infusion. This is the second biosimilar approved by the FDA. Inflectra is biosimilar to Janssen Biotech, Inc.’s Remicade (infliximab), which was originally licensed in 1998. Inflectra is approved and can be prescribed by a health care professional for the treatment of: adult patients and pediatric patients (ages six years and older) with moderately to severely active Crohn’s disease who have had an inadequate response to conventional therapy; adult patients with moderately to severely active ulcerative colitis who have had an inadequate response to conventional therapy; patients with moderately to severely active rheumatoid arthritis in combination with methotrexate; patients with active ankylosing spondylitis (arthritis of ... Read more

Related support groups: Rheumatoid Arthritis, Psoriasis, Crohn's Disease, Remicade, Ulcerative Colitis, Psoriatic Arthritis, Ankylosing Spondylitis, Plaque Psoriasis, Infliximab, Inflectra

Study: Smoking Hikes Chances of Early Death for Rheumatoid Arthritis Patients

Posted 4 Apr 2016 by Drugs.com

MONDAY, April 4, 2016 – Smoking increases the chances of early death in people with rheumatoid arthritis, but quitting smoking significantly reduces that risk, a new study suggests. "This research provides important evidence that the risk of early death starts to decline in patients who stop smoking, and continues year on year," said researcher Deborah Symmons. She is a professor of rheumatology and musculoskeletal epidemiology at the University of Manchester in England. Symmons and her colleagues analyzed data from rheumatoid arthritis patients in the United Kingdom. The investigators found that the patients who smoked were nearly twice as likely to die prematurely as those who never smoked. The risk among former smokers was similar to that of those who never smoked, and fell for each additional year they no longer smoked, the researchers said. "We hope that this research can be used ... Read more

Related support groups: Rheumatoid Arthritis, Smoking, Smoking Cessation, Nicotine, Nicorette, Juvenile Rheumatoid Arthritis, Nicoderm CQ, Nicotrol Inhaler, Commit, Habitrol, Nicotrol NS, Nicorelief, Nicorette DS, ProStep, Nicotrol TD

Experimental Drug for Rheumatoid Arthritis Shows Promise

Posted 31 Mar 2016 by Drugs.com

THURSDAY, March 31, 2016 – An experimental drug to treat rheumatoid arthritis showed promise in a new six-month trial. Baricitinib substantially reduced symptoms and improved daily physical functioning among people who failed other treatments for the autoimmune disease, researchers found. "If you have active disease and you've failed existing treatment options, you should have hope," said lead researcher Dr. Mark Genovese. He is a professor of immunology and rheumatology at Stanford University School of Medicine in California. "There is another therapy, which will hopefully become available, that has demonstrated it can work in that situation." The report was published March 31 in the New England Journal of Medicine. The trial was sponsored by Eli Lilly and Co., the manufacturer of baricitinib. Lilly is currently seeking approval of the drug from the U.S. Food and Drug Administration. ... Read more

Related support groups: Rheumatoid Arthritis, High Cholesterol, Varicella-Zoster, Varicella-Zoster - Prophylaxis

Pfizer Announces FDA Approval of Xeljanz XR (tofacitinib citrate), the First and Only Once-Daily Oral JAK Inhibitor Treatment for Rheumatoid Arthritis

Posted 25 Feb 2016 by Drugs.com

February 24, 2016 – Pfizer Inc. (NYSE:PFE) announced today that the U.S. Food and Drug Administration (FDA) has approved Xeljanz XR (tofacitinib citrate) extended-release 11 mg tablets for the once-daily treatment of moderate to severe rheumatoid arthritis (RA) in patients who have had an inadequate response or intolerance to methotrexate (MTX). Xeljanz XR is the first and only once-daily oral RA treatment in its class, known as Janus kinase (JAK) inhibitors. “Pfizer continues to be an innovator in inflammation and immunology. The introduction of the first and only once-daily oral JAK inhibitor for RA, Xeljanz XR, builds upon Pfizer’s tradition of developing patient-centered therapies,” said Michael Corbo, Category Development Lead, Inflammation & Immunology, Pfizer Global Innovative Pharmaceuticals Business. “The availability of Xeljanz XR provides physicians with a new treatment opt ... Read more

Related support groups: Rheumatoid Arthritis, Xeljanz, Tofacitinib

Health Tip: Recognizing Symptoms of Hand Arthritis

Posted 11 Nov 2015 by Drugs.com

-- Hand arthritis symptoms may be mild at first, but they can become more severe and make it difficult to grasp ordinary objects. The American Academy of Orthopaedic Surgeons mentions these typical symptoms: Pain that may feel burning or dull, and worsen after using the hand. Pain tends to ease with rest, and often is worse in the morning. Swelling or warmth of the joints. A grinding sensation in the joints. A feeling that the joints are looser than usual. Formation of cysts on the joints. Read more

Related support groups: Pain, Rheumatoid Arthritis, Osteoarthritis, Fioricet, Excedrin, Tylenol PM, Fiorinal, Juvenile Rheumatoid Arthritis, Excedrin Migraine, Advil PM, Esgic, Juvenile Idiopathic Arthritis, Headache Relief, Percogesic, Bupap, Esgic-Plus, Excedrin Extra Strength, Acetaminophen/Butalbital/Caffeine, Dolgic Plus, Aspirin/Butalbital/Caffeine

Studies Explore Link Between Diet, Rheumatoid Arthritis

Posted 9 Nov 2015 by Drugs.com

SUNDAY, Nov. 8, 2015 – Your diet may influence your chances of developing rheumatoid arthritis, two new studies suggest. The results show "that a healthy diet may prevent [rheumatoid arthritis] development, and our team is interested in conducting further studies to look at why diet is associated with this risk," said lead investigator Dr. Bing Lu, an assistant professor of medicine at Brigham and Women's Hospital and Harvard Medical School in Boston. One study included nearly 94,000 American women, aged 25 to 42, who provided information about their diet every four years between 1991 and 2011. During that time, nearly 350 of them developed rheumatoid arthritis. Those who ate a typical North American diet – high in red and processed meat, refined grains, fried food, high-fat dairy and sweets – were more likely to develop rheumatoid arthritis than those who ate a diet high in fruits, ... Read more

Related support groups: Rheumatoid Arthritis

Heart Disease Deaths Declining Among Those With Rheumatoid Arthritis: Study

Posted 9 Nov 2015 by Drugs.com

SUNDAY, Nov. 8, 2015 – Heart disease-related deaths among Americans with rheumatoid arthritis are on the decline, according to a new study. Rheumatoid arthritis patients are two times more likely than the average person to develop heart disease, but the new research finds that efforts to prevent, diagnose and treat heart disease at an early stage in these patients are paying off. Mayo Clinic researchers analyzed heart disease deaths within 10 years of rheumatoid arthritis diagnosis for two groups of people. The first group included 315 people diagnosed between 2000 and 2007. The second group included 498 people diagnosed in the 1980s and 1990s. About two-thirds of the patients were women and their average age was 60. Between 2000 and 2007, 2.8 percent died of heart disease, compared to 7.9 percent in the 1980s and 1990s, according to the findings, which are to be presented Sunday at ... Read more

Related support groups: Rheumatoid Arthritis, Heart Disease

Rheumatoid Arthritis May Shorten Life Span: Study

Posted 3 Nov 2015 by Drugs.com

TUESDAY, Nov. 3, 2015 – Rheumatoid arthritis may raise the risk of early death by as much as 40 percent, with heart and respiratory problems the most common contributors to a shortened life span, a new study suggests. And among those who died of respiratory causes, one of the main causes of death was chronic obstructive pulmonary disease (COPD), the researchers reported. The findings provide new evidence to support previous research suggesting a link between rheumatoid arthritis and increased risk of early death, and they point to the need for doctors to closely monitor these patients, the study authors said. However, the study only showed an association, and not a cause-and-effect relationship, between rheumatoid arthritis and risk of premature death. Rheumatoid arthritis is an autoimmune disorder in which the body's immune system attacks the joints, resulting in pain and swelling. ... Read more

Related support groups: High Blood Pressure, Rheumatoid Arthritis, Hypertension, Heart Disease, Heart Failure, Congestive Heart Failure, Angina, Juvenile Rheumatoid Arthritis, Left Ventricular Dysfunction, Bronchiectasis, Respiratory Tract Disease, Cardiovascular Conditions and Disorders, Ischemic Heart Disease, Hypertensive Heart Disease, Reversible Airways Disease

Drugs Used in Cancer, Arthritis May Help Fight Hair Loss

Posted 23 Oct 2015 by Drugs.com

FRIDAY, Oct. 23, 2015 – Two drugs – one approved for use in arthritis and the other approved for cancer – may also hold potential for boosting hair growth, new animal research suggests. "The ultimate potential is a very effective topical product to rub on the scalp to help with all types of hair loss," said Dr. Luis Garza, an associate professor of dermatology at Johns Hopkins School of Medicine, who's familiar with the study findings. But he added, "More work needs to be done to translate these findings to a product which can be tested in a clinical trial on people." In the current study, researchers from Columbia University in New York City tested the drugs only on mice, including some with patches of human skin. If the medications work, it's not clear how much of the drugs may be needed for humans. It's also important to note that findings that look promising in animal research ... Read more

Related support groups: Rheumatoid Arthritis, Cancer, Alopecia, Xeljanz, Diagnosis and Investigation, Jakafi, Ruxolitinib, Tofacitinib

Could Oral Contraceptives Help Ease Rheumatoid Arthritis?

Posted 28 Aug 2015 by Drugs.com

FRIDAY, Aug. 28, 2015 – Oral contraceptives – also known as birth control pills – may ease pain and improve functioning in women with rheumatoid arthritis, a small German study suggests. "Women with inflammatory arthritis who were currently using oral contraceptives or who had used them in the past, presented with better patient-reported outcomes within the first two years of arthritis," the study authors wrote. Rheumatoid arthritis is an autoimmune disorder in which the body's immune system attacks the joints, resulting in pain and swelling. About 1.3 million people in the United States have rheumatoid arthritis, and of these, nearly 75 percent are women, according to the American College of Rheumatology. Dr. Waseem Mir, a rheumatologist at Lenox Hill Hospital in New York City, noted, "We have to take the findings of the study with great caution." Mir was not involved in the current ... Read more

Related support groups: Birth Control, Contraception, Plan B, Rheumatoid Arthritis, Mirena, Sprintec, NuvaRing, Implanon, Provera, Nexplanon, Depo-Provera, Ortho Tri-Cyclen, Tri-Sprintec, Yasmin, Microgestin Fe 1/20, Loestrin 24 Fe, Ortho Evra, Plan B One-Step, TriNessa, Lutera

Knee Replacement May Ease Pain for Rheumatoid Arthritis Patients

Posted 30 Jul 2015 by Drugs.com

THURSDAY, July 30, 2015 – Knee replacement surgery can temporarily return the joint to an earlier, better level of function in patients with rheumatoid arthritis, new research suggests. The surgery "acts like a time machine" for these patients, said study senior author Kaleb Michaud, an associate professor of internal medicine in the division of rheumatology at the University of Nebraska Medical Center, in Omaha. "It's a very important treatment option, and our study is really about showing how their lives improved afterwards," Michaud said. Most studies of knee replacement surgery focus on patients with osteoarthritis, the "wear-and-tear" form of arthritis. This kind of arthritis involves the breakdown of cartilage, the cushiony material at the ends of bones. On the other hand, patients who have the autoimmune disease rheumatoid arthritis experience painful inflammation and swelling ... Read more

Related support groups: Rheumatoid Arthritis, Knee Joint Replacement

Severe Burns May Trigger Dangerous Shifts in Gut Germs

Posted 8 Jul 2015 by Drugs.com

WEDNESDAY, July 8, 2015 – People who suffer severe burns may experience potentially dangerous changes in the 100 trillion bacteria inside their gastrointestinal (GI) tract, a small study suggests. At issue is the breakdown of good and bad bacteria typically found inside a healthy person's GI tract. Researchers from the health sciences division of Loyola University Chicago in Maywood, Ill., observed that after a severe burn, four patients experienced a big increase in the number of potentially harmful bacteria and a corresponding drop in relatively beneficial bacteria. The potentially harmful bacteria are part of a family that includes E. coli and salmonella. Such an imbalance, known as "dysbiosis," has been linked to many conditions, including inflammatory bowel disease, obesity, rheumatoid arthritis and diabetes, study lead author Dr. Mashkoor Choudhry, a professor of surgical ... Read more

Related support groups: Diabetes, Type 2, Obesity, Rheumatoid Arthritis, Gastrointestinal Disorders, Inflammatory Bowel Disease, Burns - External, Burns, Nitrogen Retention

Health Tip: Is Arthritis Affecting Your Hands?

Posted 7 Jul 2015 by Drugs.com

-- Arthritis in the joints of the hands can be painful and make many daily tasks difficult. The American Academy of Orthopaedics says symptoms may include: Joint pain ranging from dull to burning. Pain tends to be worse after hand and finger use, and in the morning. Swelling of the joints. Sensations of grating, grinding or looseness of hand joints. Development of cysts on the hands and fingers. Read more

Related support groups: Rheumatoid Arthritis, Osteoarthritis, Psoriatic Arthritis, Juvenile Rheumatoid Arthritis, Gouty Arthritis

Drug for Rheumatoid Arthritis May Also Help Ease Vitiligo

Posted 24 Jun 2015 by Drugs.com

WEDNESDAY, June 24, 2015 – It's only been tested in one patient so far, but researchers report that a drug for rheumatoid arthritis may be a promising treatment for the discoloring skin condition known as vitiligo. Vitiligo is characterized by a disfiguring loss of pigmentation in skin. Most notably, pop star Michael Jackson suffered from the disorder much of his adult life. According to the Yale University researchers, current treatments are limited to steroid creams and light therapy, neither of which is reliably effective. "Current treatments for vitiligo can be cumbersome, expensive and have side effects, besides being less than optimal in results," said Dr. Doris Day, a dermatologist at Lenox Hill Hospital in New York City. She added that the downsides of vitiligo go beyond the cosmetic. "We know that appearance has a powerful impact on self esteem, and having white blotches that ... Read more

Related support groups: Rheumatoid Arthritis, Vitiligo, Xeljanz, Diagnosis and Investigation, Tofacitinib

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