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Restless Legs Syndrome Blog

Related terms: Ekbom Disease, RLS, Willis-Ekbom Disease

New Drug Shows Promise for Restless Legs Syndrome: Study

Posted 12 Feb 2014 by Drugs.com

WEDNESDAY, Feb. 12, 2014 – For relieving symptoms of restless legs syndrome and slowing its progression, the drug pregabalin (Lyrica) outperformed the current standard medication in a head-to-head comparison, a new study found. Pramipexole (Mirapex), which is commonly used to treat this neurological disease, makes many people worse, said lead researcher Richard Allen, an associate professor of neurology at Johns Hopkins University School of Medicine in Baltimore. Lyrica works just as well and doesn't worsen the condition, Allen said. People with restless legs syndrome – now also known as Willis-Ekbom disease – feel throbbing, creeping or other unpleasant sensations in the legs and an uncontrollable urge to move them. Symptoms occur primarily at night, and most people with restless legs syndrome have trouble falling asleep and staying asleep. Moving the legs relieves the discomfort; ... Read more

Related support groups: Lyrica, Restless Legs Syndrome, Pregabalin

Restless Legs Syndrome Tied to Earlier Death Risk

Posted 12 Jun 2013 by Drugs.com

WEDNESDAY, June 12 – Men with restless legs syndrome now have another health concern: New research has just linked the condition to an increased risk of dying early. In a study of nearly 20,000 men, Harvard researchers found that men with restless legs syndrome had a 39 percent higher risk of an early death than did men without the condition. "This study suggests that individuals with restless legs syndrome are more likely to die early than other people," said study author Dr. Xiang Gao, an assistant professor at Harvard Medical School and an associate epidemiologist at Brigham and Women's Hospital in Boston. "This association was independent of other known risk factors." "[However], this is an observational study," Gao said of the findings, which were published online June 12 in the journal Neurology. "We can only see an association that suggests a possible causal relationship." ... Read more

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Drugs May Help Relieve Restless Legs Syndrome

Posted 4 Mar 2013 by Drugs.com

MONDAY, March 4 – People suffering from restless legs syndrome may find some relief by taking one of several drugs approved to treat the condition, a new review confirms. The medications, which include Requip (ropinirole), levodopa, Neurontin (gabapentin) and Lyrica (pregabalin), appear to reduce symptoms of the syndrome in more than 60 percent of patients, researchers report. The first two drugs raise dopamine levels in the body, and the last two drugs reduce the amount of calcium reaching brain cells and trigger the production of other chemicals that help reduce pain. Dopamine is a brain chemical that regulates movement and mood. "Physicians and patients now have better information on the effectiveness and harms of two types of drug treatments for patients with at least moderately severe restless legs symptoms in which to guide treatment choices," said review author Dr. Timothy Wilt, ... Read more

Related support groups: Gabapentin, Lyrica, Neurontin, Restless Legs Syndrome, Pregabalin, Requip, Ropinirole, Levodopa, Gralise, Horizant, Requip XL, Requip Starter Kit, Gabarone, Repreve, Fanatrex, ReQuip Follow on Pack, Dopar, ReQuip Starter Pack, Larodopa

FDA Medwatch Alert: Mirapex (pramipexole): Drug Safety Communication - Ongoing Safety Review, Possible Risk of Heart Failure

Posted 19 Sep 2012 by Drugs.com

ISSUE: FDA notified healthcare profesionals about a possible increased risk of heart failure with Mirapex (pramipexole). Results of recent studies suggest a potential risk of heart failure that needs further review of available data. Because of the study limitations, FDA is not able to determine whether Mirapex increases the risk of heart failure. FDA is continuing to work with the manufacturer to clarify further the risk of heart failure with Mirapex and will update the public when more information is available. FDA evaluated a pooled analysis of randomized clinical trials and found that heart failure was more frequent with Mirapex than with placebo; however, these results were not statistically significant. FDA also evaluated two epidemiologic studies that suggested an increased risk of new onset of heart failure with Mirapex use. However, study limitations make it difficult to ... Read more

Related support groups: Restless Legs Syndrome, Parkinson's Disease, Mirapex, Pramipexole

Drug Patch Approved for Advanced Parkinson's and Restless Leg Syndrome

Posted 3 Apr 2012 by Drugs.com

TUESDAY, April 3 – The Neupro (rotigotine) transdermal system has been approved by the U.S. Food and Drug Administration to treat advanced Parkinson's disease and moderate-to-severe restless leg syndrome, the Belgian drug maker UCB said Tuesday in a news release. The continuous drug delivery patch was first approved by the FDA in 2007 to treat early-stage Parkinson's. The dopamine agonist skin patch is believed to work by stimulating dopamine receptors within the caudate-putamen, the portion of the brain that regulates movement, the company said. In clinical testing, observed side effects of Neupro included nausea, vomiting, skin site reactions, dizziness, insomnia and headache. Neupro contains sodium metabisulfite, which could cause deadly allergic-like reactions in certain susceptible people. Also, the drug should not be used by pregnant women, UCB warned. More information To learn ... Read more

Related support groups: Restless Legs Syndrome, Parkinson's Disease, Neupro, Rotigotine

Classic Restless Legs Syndrome Not Linked to Parkinson's

Posted 10 Nov 2011 by Drugs.com

THURSDAY, Nov. 10 – People with early Parkinson's disease are not more likely to have restless legs syndrome, but many people with Parkinson's do report leg motor restlessness, according to the results of a new Norwegian study. People with restless legs syndrome, or RLS, have an overwhelming urge to move their legs. This typically occurs at night during rest, and the sensation is relieved by movement. By contrast, leg motor restlessness is characterized by the urge to move the legs throughout the day, and this sensation does not improve with movement. Both RLS and Parkinson's disease, which is a chronic and progressive movement disorder that affects nearly 1 million people in the United States, do respond to the same drugs, but that is where their connection ends. Medications that boost levels of the brain chemical dopamine treat both conditions. To better understand the relationship ... Read more

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Restless Legs Syndrome May Boost Blood Pressure

Posted 10 Oct 2011 by Drugs.com

MONDAY, Oct. 10 – Middle-aged women who suffer from a common condition called restless legs syndrome may be at increased risk of high blood pressure, U.S. researchers report. Restless legs syndrome is a sensory motor disorder that causes intense, unpleasant leg sensations, and an irresistible urge to move the legs, often at night. The condition, which may affect between 5 to 15 percent of U.S. adults, can disrupt sleep and cause daytime drowsiness. "For those who experience restless legs syndrome symptoms, please consult your doctor regarding this issue," said lead researcher Dr. Xiang Gao, an assistant professor of medicine at the Harvard Medical School. "The risk of hypertension can be substantially reduced by following a healthy life style, including a healthy diet, regular physical activity, and keeping optimal body weight," he added. Unabated, hypertension, also known as high ... Read more

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Genes Linked to Restless Legs Syndrome Identified

Posted 14 Jul 2011 by Drugs.com

THURSDAY, July 14 – An international team of researchers has identified two genetic regions that seem to be implicated in restless legs syndrome. Restless legs syndrome is a condition in which people experience a tingling or "creepy crawly" feeling in the legs, relieved only by movement. One of the most common neurological diseases, the syndrome can lead to chronic sleep loss, daytime fatigue and even depression. In the new study, scientists from Europe, Canada and the United States analyzed genetic sequence variants in nearly 5,000 people suffering from restless legs syndrome along with more than 7,000 people who did not have the condition. The researchers found two new genetic regions that play a role in the syndrome. One of the regions is within a gene involved in regulating brain activity, known as TOX3, according to the report published online July 14 in PLoS Genetics. Although ... Read more

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Impotence Linked to Restless Legs Syndrome

Posted 15 Jun 2011 by Drugs.com

WEDNESDAY, June 15 – Men who struggle with restless legs syndrome face a higher risk of impotence, a new study suggests. The study, by researchers from Harvard University, builds on earlier research by the scientists that found that impotence, or erectile dysfunction, was more common among older men with restless legs syndrome – and the more frequent the symptoms of the sleep disorder the higher the risk of impotence. For the new study, the researchers started with more than 11,000 men, with an average age of 64 at the start of the trial in 2002, who did not suffer from impotence, diabetes or arthritis. The trial, called the Health Professionals Follow-up Study, began with the men answering a standardized set of health-related questions. Men were considered to have restless legs syndrome (RLS) if they met four RLS diagnostic criteria recommended by the International RLS Study Group ... Read more

Related support groups: Restless Legs Syndrome, Erectile Dysfunction

GlaxoSmithKline and XenoPort Receive FDA Approval for Horizant

Posted 7 Apr 2011 by Drugs.com

LONDON & RESEARCH TRIANGLE PARK, N.C. & SANTA CLARA, Calif.--(BUSINESS WIRE)--Apr 6, 2011 - GlaxoSmithKline (NYSE: GSK) and XenoPort, Inc. announced Wednesday that the U.S. Food and Drug Administration (FDA) has approved Horizant (gabapentin enacarbil) Extended-Release Tablets for the treatment of moderate-to-severe primary Restless Legs Syndrome in adults. Horizant is not recommended for patients who are required to sleep during the daytime and remain awake at night. The efficacy of Horizant in the treatment of patients with moderate-to-severe primary Restless Legs Syndrome was demonstrated in two 12-week clinical trials in adults. It is the first medication in its class to be approved for the treatment of moderate-to-severe primary Restless Legs Syndrome. "Clinical experience has substantiated that Restless Legs Syndrome, also referred to as Ekbom Disease, is a long-term neurological ... Read more

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Home Dialysis for Kidney Patients May Ease Restless Legs Syndrome

Posted 21 Mar 2011 by Drugs.com

FRIDAY, March 18 – Short, daily sessions of hemodialysis at home may reduce sleep problems caused by restless legs syndrome in dialysis patients, according to new research. The study – sponsored and funded by NxStage Medical Inc., which makes home dialysis products – is published online March 17 in the Clinical Journal of the American Society of Nephrology. Dialysis patients are about four times more likely than people in the general population to experience restless legs syndrome (RLS), which causes abnormal sensations such as pins and needles or creepy-crawly feelings in the legs while at rest. Restless legs syndrome can interfere with sleep. This study included 235 patients who performed dialysis at home for a few hours six days a week, as an alternative to center-based treatment. This led to significant improvement in restless legs symptoms, according to the researchers. "Over 12 ... Read more

Related support groups: Restless Legs Syndrome, Renal Failure

Restless Legs in Pregnancy Likely to Recur, Researchers Say

Posted 6 Dec 2010 by Drugs.com

MONDAY, Dec. 6 – Women who experience restless legs syndrome (RLS) during pregnancy are at increased risk for having it again during future pregnancies or developing a chronic form of the condition later in life, researchers have found. RLS causes unpleasant sensations in the legs. Symptoms are generally worse at night and tend to progress with age. Movement generally relieves symptoms. Italian researchers recruited 74 women who had RLS during pregnancy and 133 who did not. Six-and-a-half years later, the women were interviewed about RLS symptoms, additional pregnancies, occurrences of other diseases and medication use. Of the women who had RLS during pregnancy, 18 (24 percent) also had the disorder at the end of the study, compared to 10 (8 percent) of the women who did not have RLS during pregnancy, the investigators found. About 60 percent of the women who had RLS during a first ... Read more

Related support groups: Restless Legs Syndrome

Restless Legs Syndrome, Fibromyalgia Linked in Study

Posted 17 Oct 2010 by Drugs.com

FRIDAY, Oct. 15 – People with fibromyalgia are 11 times more likely to have restless legs syndrome (RLS) than those in the general population, according to a new study. Fibromyalgia is a condition that can cause significant pain and fatigue. Women account for 80 to 90 percent of patients diagnosed with fibromyalgia. Its cause is unknown. The findings suggest that treating RLS – which is characterized by an unpleasant urge to move the legs, usually at night – may improve sleep and quality of life for people with fibromyalgia, the researchers said. RLS is often treated with drugs such as pramipexole or ropinirole. In this study, U.S. researchers compared 172 fibromyalgia patients, average age 50, with a control group of 63 healthy people, average age 41. The prevalence of RLS was about 10 times higher in the fibromyalgia group (93 percent of whom were female) than in the control group ... Read more

Related support groups: Fibromyalgia, Restless Legs Syndrome

Restless Legs Syndrome Can Have Family Ties

Posted 10 May 2010 by Drugs.com

MONDAY, May 10 – Siblings and family members of people who have restless legs syndrome are also more likely to suffer from the condition, a new report suggests. The authors of the study, which is published in the May issue of Archives of Neurology, hope the findings will raise awareness of the condition for both physicians and patients. "These authors found very stark significant evidence that if you have a sibling or a family member with restless legs syndrome, you have a very high risk of having it," said Dr. Carl Boethel, assistant professor of internal medicine at Texas A&M Health Science Center College of Medicine and medical director of the Sleep Institute at Scott & White in Temple, Texas. That means if you have a family member and, particularly, a sibling with restless legs syndrome, or RLS, you might want to get screened, he said. Fortunately, said study senior author Dr. Guy ... Read more

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Restless Legs Linked to Erectile Dysfunction

Posted 5 Jan 2010 by Drugs.com

TUESDAY, Jan. 5 – Men with restless leg syndrome are more likely to have erectile dysfunction, new research suggests, but it's not clear how the two conditions are related. "There is an association, but we don't know which one comes first," said study author Dr. Xiang Gao, an instructor in medicine at Harvard University School of Public Health. If researchers do discover how they're connected, it could lead to more effective treatments, he said. Restless leg syndrome "afflicts a significant portion of our population and in a minority of cases can cause insomnia and other important consequences," said Dr. Robert Vorona, an associate professor at Eastern Virginia Medical School in Virginia who studies sleep disorders. Its causes remain a mystery, Vorona said, but some evidence suggests it's related to reduced levels of iron and the neurotransmitter known as dopamine in the brain. Those ... Read more

Related support groups: Restless Legs Syndrome, Erectile Dysfunction

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