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Steroids No Better for Sciatica Pain Than Placebo, Study Finds

Posted 9 days ago by Drugs.com

TUESDAY, May 19, 2015 – Doctors often prescribe steroid pills to ease the discomfort of sciatica – back and leg pain usually caused by a herniated disk in the lower back. But a new study finds steroids are no more effective than a placebo pill for the pain and provide only modest improvement in function. Sciatica affects about one in 10 people in their lifetime, the researchers said. For this study, 269 people with sciatica were randomly assigned to take an oral steroid (prednisone) or a placebo (a dummy medication) for 15 days. The participants were followed for up to a year. "When we compared the prednisone to placebo, there was a modest improvement in function," said study researcher Dr. Harley Goldberg, director of spine care services at Kaiser Permanente San Jose Medical Center in California. People reported they could go about their daily activities somewhat better than before. ... Read more

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Many ER Patients With Chest Pain Can Be Sent Home, Study Finds

Posted 10 days ago by Drugs.com

MONDAY, May 18, 2015 – While chest pain sends many people to the nearest hospital emergency department, most patients may not need a costly hospital stay as a result, a new study suggests. According to a news release from Ohio State University, chest pain sends more than 7 million Americans to the ER every year and about half of them are then admitted for further observation, testing or treatment. But is the cost and inconvenience of a hospital stay always warranted? The study aimed to "assess whether this population of patients could safely go home and do further outpatient testing within a day or two," lead researcher Dr. Michael Weinstock, a professor of emergency medicine at the university's College of Medicine, said in the news release. His team looked at data from more than 11,000 visits by patients experiencing chest pain to three hospitals in Columbus, Ohio between 2008 and ... Read more

Related support groups: Pain, Heart Disease, Atrial Fibrillation, Heart Attack, Tachyarrhythmia, Angina, Myocardial Infarction, Coronary Artery Disease (CAD), Bradyarrhythmia, Angina Pectoris Prophylaxis, Cardiovascular Risk Reduction, Diagnosis and Investigation, Ischemic Heart Disease, Myocardial Infarction - Prophylaxis, Cardiovascular Conditions and Disorders, Acute Coronary Syndrome - Prophylaxis, Abnormal Electrocardiogram

Insomniacs May Be More Sensitive to Pain

Posted 16 days ago by Drugs.com

TUESDAY, May 12, 2015 – People with insomnia or poor sleep quality may be less tolerant of pain, new research suggests. The more frequent and severe the insomnia, the greater the sensitivity to pain, the Norwegian study showed. Additionally, the researchers noted that people with insomnia who also suffer from chronic pain have an even lower threshold for physical discomfort. It's important to note, however, that while the study found an association between a lack of quality sleep and increased pain sensitivity, it wasn't designed to show a cause-and-effect relationship. The study, led by Borge Sivertsen, of the Norwegian Institute of Public Health in Bergen, involved more than 10,000 adults. The study participants all underwent a standard test of pain sensitivity by dunking their hands in a bath of cold water for 106 seconds. The volunteers were also asked about their sleep quality. ... Read more

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New Moms' Codeine Use Down Since Health Warnings

Posted 16 days ago by Drugs.com

TUESDAY, May 12, 2015 – Fewer new mothers have been prescribed the painkiller codeine since public health officials warned about a rare, but potential risk of overdose for breast-feeding babies, a new study says. Experts said the study results, reported in the May 12 Journal of the American Medical Association, are good news. "The trend is going in the direction we want it," said lead researcher Kate Smolina, of the University of British Columbia, in Vancouver, Canada. On the other hand, she added, a significant number of women were still being prescribed codeine in 2011 – three to four years after U.S. and Canadian health officials first issued their warnings. "Prescriptions are still too high," Smolina said. "We'd like to see it closer to zero." Codeine is an ingredient in certain prescription painkillers and cough medications. It was long considered the safest narcotic painkiller ... Read more

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Spinal Stimulation System Relieves Pain Without Tingling

Posted 17 days ago by Drugs.com

MONDAY, May 11, 2015 – The Senza spinal cord stimulation system has been approved by the U.S. Food and Drug Administration to treat chronic back pain without the tingling sensation that characterizes more traditional pain-relieving methods. The implanted device uses high-frequency stimulation to avoid the tingling sensation known as "paresthesia," the agency said in a news release. Spinal pain could be characterized by conditions including failed back surgery syndrome, low back pain and leg pain. Before treatment with Senza begins, potential users are treated with a trial system for a week or two, the FDA said. Once a physician determines that the trial device has worked, patients have minimally invasive surgery to implant Senza in the upper buttocks or abdomen. The device includes a patient-operated remote control. Senza's safety and effectiveness were clinically evaluated in a study ... Read more

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Babies May Be More Sensitive to Pain Than Adults

Posted 21 Apr 2015 by Drugs.com

TUESDAY, April 21, 2015 – Babies feel pain in much the same way as adults, says a new study that challenges some experts' beliefs that babies don't feel pain. Some people have argued that babies' brains aren't developed enough for them to really "feel" pain, said study lead author Dr. Rebeccah Slater, of the department of pediatrics at Oxford University in England. "Our study provides the first really strong evidence that this is not the case," Slater said. "Our study suggests that not only do babies experience pain, but they may be more sensitive to it than adults," she said in a university news release. The study included 10 healthy infants, ages 1 to 6 days, and 10 healthy adults, ages 23 to 36. All underwent MRI scans of their brains while they were poked on the bottom of their feet. The results showed that 18 of the 20 brain regions that were active in adults in response to pain ... Read more

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Health Tip: Exercising With Knee Problems

Posted 14 Apr 2015 by Drugs.com

-- Exercise may be just what the doctor ordered if you have knee pain. The American Academy of Orthopaedic Surgeons suggests: Start out exercising slowly, and over time build up the duration and intensity of your workout. While some discomfort is OK, pain is not. You should stop if you feel pain in your knee. A little stiffness or soreness is OK, but significant pain the day after exercising probably means you've overdone it. Talk to your doctor or physical therapist if you have questions about exercising with knee pain. Read more

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FDA Issues Final Guidance on the Evaluation and Labeling of Abuse-Deterrent Opioids

Posted 1 Apr 2015 by Drugs.com

April 1, 2015 – The U.S. Food and Drug Administration today issued a final guidance to assist industry in developing opioid drug products with potentially abuse-deterrent properties. Opioid drugs provide significant benefit for patients when used properly; however opioids also carry a risk of misuse, abuse and death. To combat opioid misuse and abuse, the FDA is encouraging manufacturers to develop abuse-deterrent drugs that work correctly when taken as prescribed, but, for example, may be formulated in such a way that deters misuse and abuse, including making it difficult to snort or inject the drug for a more intense high. While drugs with abuse-deterrent properties are not “abuse-proof,” the FDA sees this guidance as an important step toward balancing appropriate access to opioids for patients with pain with the importance of reducing opioid misuse and abuse. The document “Gu ... Read more

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One-Quarter of Narcotic Painkillers Misused, Study Shows

Posted 1 Apr 2015 by Drugs.com

WEDNESDAY, April 1, 2015 – Almost a quarter of powerful narcotic painkillers that are prescribed for chronic pain are misused, and the rate of addiction among patients hovers near 10 percent, a new review shows. The findings raise questions about the benefits of widespread use of these painkillers to treat chronic pain, the researchers said. "On average, misuse was documented in approximately one out of four or five patients, and addiction [was found] in approximately one out of 10 or 11 patients," who were prescribed the drugs as part of their treatment for chronic pain, wrote Kevin Vowles, from the University of New Mexico, and colleagues. In the new review, researchers analyzed 38 published studies, 35 of which were conducted in the United States. The average rates of misuse were 21 percent to 29 percent, while the average rates of addiction were 8 percent to 12 percent, according ... Read more

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Young Pitchers Often Pressured to Play Despite Pain, Study Says

Posted 24 Mar 2015 by Drugs.com

TUESDAY, March 24, 2015 – Young baseball players feel pressure from parents or coaches to continue playing despite arm pain, and many parents are unaware of guidelines to reduce injury risk, a pair of recent studies found. "Kids are playing harder and longer in more leagues than ever before," said Dr. Paul Saluan, director of pediatric and adolescent sports medicine at the Cleveland Clinic. "Kids also are not getting enough rest in between episodes of pitching, which may lead to insufficient time to heal smaller stress injuries. Over time, these smaller injuries add up." The studies are scheduled for presentation March 24 at the American Academy of Orthopaedic Surgeons' annual meeting in Las Vegas. Data and conclusions presented at meetings are usually considered preliminary until published in a peer-reviewed medical journal. The co-author of one of the studies explained how players ... Read more

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British Scientists Spot Brain's Pain Center

Posted 9 Mar 2015 by Drugs.com

MONDAY, March 9, 2015 – British researchers say they've identified the area of the brain linked to pain intensity. The University of Oxford team used a new imaging technique to observe how different levels of pain affected the brains of 17 volunteers. Activity in only one area of the brain – the dorsal posterior insula – matched the participants' self-reported pain ratings. This method could be used to help assess pain levels in people who have difficulty providing doctors with that information, such as those in a coma, small children or dementia patients, said the authors of the study published March 9 in the journal Nature Neuroscience. "We have identified the brain area likely to be responsible for the core, 'it hurts', experience of pain," researcher Irene Tracey said in a university news release. "Pain is a complex, multidimensional experience, which causes activity in many ... Read more

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Narcotic Painkiller Use Tied to Higher Risk for Depression

Posted 20 Feb 2015 by Drugs.com

FRIDAY, Feb. 20, 2015 – High doses of powerful narcotic painkillers appear to be linked to a higher risk of depression in patients, new research finds. The study focuses on a class of prescription narcotic painkillers called opioids, which include drugs such as Oxycontin and Vicodin. While most people use the medicines to ease pain, widespread abuse of narcotic painkillers is also a growing concern. The new study involved 355 patients in Texas who reported low back pain at an initial medical visit and still had the pain one and two years later. Although the study couldn't prove cause-and-effect, people who used higher doses of narcotic painkillers to manage their pain were more likely to have an increase in depression, the researchers found. Learning more about the link between these painkillers and depression, along with what dosage might put patients at higher risk, "may inform ... Read more

Related support groups: Pain, Depression, Back Pain

Many Americans Face Pain, Depression in Their Final Year

Posted 2 Feb 2015 by Drugs.com

MONDAY, Feb. 2, 2015 – For a growing number of Americans, the final year of life is marked by pain, depression and other distressing symptoms, a new study finds. Experts said the study, published Feb. 2 in Annals of Internal Medicine, highlights disturbing shortcomings in the U.S. health care system. Researchers found that between 1998 and 2010, the number of Americans who suffered pain in their last year of life rose from 54 percent to 61 percent. Meanwhile, the prevalence of depression rose from 45 percent to 57 percent, while other symptoms – such as breathlessness, confusion, severe fatigue and incontinence – either increased or did not improve. "These findings are troubling," said senior researcher Dr. Karl Lorenz, of the Pardee RAND Graduate School and the University of California, Los Angeles. The increase in end-of-life symptoms, Lorenz said, has occurred despite national ... Read more

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Zogenix Receives FDA Approval for New Abuse-Deterrent Formulation of Zohydro ER

Posted 30 Jan 2015 by Drugs.com

SAN DIEGO, Jan. 30, 2015 – Zogenix, Inc. (Nasdaq:ZGNX), a pharmaceutical company developing and commercializing products for the treatment of central nervous system (CNS) disorders, today announced that the U.S. Food and Drug Administration (FDA) has approved a new formulation of Zohydro ER (hydrocodone bitartrate) Extended-Release Capsules, CII, with BeadTek™. BeadTek is a formulation technology designed to provide abuse-deterrent properties without changing the release properties of hydrocodone when Zohydro ER is used as intended. Concurrently, Zogenix has ongoing Human Abuse Liability studies, which will further characterize the abuse-deterrent properties of the new formulation. Zogenix intends to submit these data in the second half of 2015 to the FDA to support an amended product label, including abuse-deterrent claims consistent with the FDA's current draft Guidance for Industry, ... Read more

Related support groups: Pain, Hydrocodone, Zohydro

FDA Medwatch Alert: Prescription and Over-the-Counter (OTC) Pain Medicines: Drug Safety Communication - FDA Review of Possible Risks of Pain Medicine Use During Pregnancy

Posted 20 Jan 2015 by Drugs.com

[Posted 01/09/2015] ISSUE:  FDA is aware of and understands the concerns arising from recent reports questioning the safety of prescription and over-the-counter (OTC) pain medicines when used during pregnancy. As a result, FDA evaluated research studies published in the medical literature and determined they are too limited to make any recommendations based on these studies at this time. Because of this uncertainty, the use of pain medicines during pregnancy should be carefully considered. FDA urges pregnant women to always discuss all medicines with their health care professionals before using them. Severe and persistent pain that is not effectively treated during pregnancy can result in depression, anxiety, and high blood pressure in the mother. Medicines including nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, and acetaminophen can help treat severe and persistent pain. ... Read more

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dextromethorphan / phenylephrine, morphine / naltrexone, capsaicin / menthol / methyl salicylate topical, rofecoxib, pentafluoropropane / tetrafluoroethane, meclofenamate, morphine liposomal, aspirin / diphenhydramine, aspirin / codeine, acetaminophen / caffeine / phenyltoloxamine, acetaminophen / caffeine / phenyltoloxamine / salicylamide, acetaminophen / dextromethorphan, acetaminophen / caffeine / magnesium salicylate / phenyltoloxamine, acetaminophen / aspirin / caffeine / salicylamide, acetaminophen / aluminum hydroxide / aspirin / caffeine / magnesium hydroxide, acetaminophen / aspirin, acetaminophen / dextromethorphan / doxylamine, acetaminophen / diphenhydramine, aspirin / caffeine / dihydrocodeine, aspirin / caffeine / salicylamide, aspirin / carisoprodol / codeine, aluminum hydroxide / aspirin / calcium carbonate / magnesium hydroxide, alfentanil, acetaminophen / guaifenesin, acetaminophen / phenyltoloxamine / salicylamide, bupivacaine liposome, capsaicin / lidocaine / menthol / methyl salicylate, Tolectin DS, Tolectin 600, Mapap Children's, Numorphan, Percocet 7.5 / 500, LMX 5, Infumorph, Children's Silapap, Febrol Solution, Farbital, Xylocaine Topical, Astramorph PF, Medi-Seltzer, Capital w / Codeine, EC-Naprosyn, Duraclon, Lidosense 5, Oruvail, capsaicin / lidocaine / menthol, Dolorex, Duraxin, acetaminophen / aspirin / diphenhydramine, diphenhydramine / naproxen, acetaminophen / magnesium salicylate, naloxone / oxycodone, Tylophen, Genapap, IBU, Combunox, Indocin SR, Aspiritab, Tylenol 8 Hour, Aceta w / Codeine, Mapap, Umphamol, Remedol, YSP Aspirin, Aspirin Lite Coat, Duragesic-75, Zero-Order Release, Acetylsalicylic Acid, Stanback Analgesic, Norwich Aspirin, Ionsys, Hydrostat IR, Doloral, Doloral Sirop, Morphitec, Morphine Rapi-Ject, Rescudose, Duramorph PF, Roxanol 100, Therapy Bayer, Bufferin Extra Strength, Bayer Plus, Buffex, Ecotrin Maximum Strength, Empirin, Halfprin, Vanatrip, Sloprin, Entercote, Extra Strength Bayer, Minitabs, Tri-Buffered Aspirin, Entaprin, Litecoat Aspirin, Genprin, Genacote, Gennin-FC, M-Oxy, ETH-Oxydose, Mobidin, Nuprin Backache Caplet, Vistazine, Magan, Numorphan HCl, Outgro Pain Relief, Rid-A-Pain, Tronothane, Prax, Trixaicin HP, Capsin, Capsicum Oleoresin, RT Capsin, Dolorac, Sarna Ultra, Sucrets, Wild Cherry, LTA II Kit, LTA Pediatric Kit, Xylocaine 10% Oral, Dermaflex, Medi-Quik Spray, Lidomar, Anestacon, Endocodone, PP-Cap, Protech First Aid Stik, Ela-Max, Laryng-O-Jet Spray, Senatec, LTA Preattached 360 Kit, LMX 4, LMX 4 with Tegaderm, Ela-Max 5, LMX Plus, Tolectin, Mapap Rapid Tabs, Sigma Pain Relief, Pain Clear Paracetamol, Setamol, Pharmore Paracetamol, Pacimol Caplets, Priceline Paracetamol, Panadol Gel Caps, Paraspen Drops, Panadol Colourfree Drops, Sigma Paracetamol, Febridol Infant Drops, Accidental Rapatabs, Paracetamol Soluble, Panadol Extend, Pharmaction Paracetamol, Hexal Comfarol, Paracare, Pharmacist Paracetamol, Silapap Infants, Cuprofen for Children, Mandanol Infant, Parmol, Febridol, Panamax 240, Parahexal, Mandanol 6+, Duatrol SR, Promax, Panadol Gel Tabs, Panadol Mini Caps, Dymadon, Paraspen, Mapap Meltaway, Mapap Arthritis Pain, Lemsip Headcold, Lemsip Original, Paracetamol Biogaran, Paracetamol EG, Paracetamol Ivax, Paracetamol Arrow, Paracetamol Almus, Expandox, Geluprane, Paracetamol Merck, Paracetamol Qualimed, Paracetamol Winthrop, Paracetamol Zydus, Paralyoc, Paracetamol Teva, Paracetamol Sandoz, Paracetamol Ranbaxy, Paracetamol RPG, Efferalgan Pediatrique, Efferalgan, Panadol Soluble, Rex Paracetamol, Paineze Paracetamol, Panadol Rapid Handipak, Benylin Sore Throat, Bydol, Chem Mart Chemadol, Panamol, Tempol, Dolko, Dolko Enfants, Dolotec, Dolitabs, Doliprane Sans Sucre, Taminol, Doliprane Adultes, Zostrix Sports