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Young Pitchers Often Pressured to Play Despite Pain, Study Says

Posted 8 days ago by Drugs.com

TUESDAY, March 24, 2015 – Young baseball players feel pressure from parents or coaches to continue playing despite arm pain, and many parents are unaware of guidelines to reduce injury risk, a pair of recent studies found. "Kids are playing harder and longer in more leagues than ever before," said Dr. Paul Saluan, director of pediatric and adolescent sports medicine at the Cleveland Clinic. "Kids also are not getting enough rest in between episodes of pitching, which may lead to insufficient time to heal smaller stress injuries. Over time, these smaller injuries add up." The studies are scheduled for presentation March 24 at the American Academy of Orthopaedic Surgeons' annual meeting in Las Vegas. Data and conclusions presented at meetings are usually considered preliminary until published in a peer-reviewed medical journal. The co-author of one of the studies explained how players ... Read more

Related support groups: Pain, Muscle Pain

British Scientists Spot Brain's Pain Center

Posted 9 Mar 2015 by Drugs.com

MONDAY, March 9, 2015 – British researchers say they've identified the area of the brain linked to pain intensity. The University of Oxford team used a new imaging technique to observe how different levels of pain affected the brains of 17 volunteers. Activity in only one area of the brain – the dorsal posterior insula – matched the participants' self-reported pain ratings. This method could be used to help assess pain levels in people who have difficulty providing doctors with that information, such as those in a coma, small children or dementia patients, said the authors of the study published March 9 in the journal Nature Neuroscience. "We have identified the brain area likely to be responsible for the core, 'it hurts', experience of pain," researcher Irene Tracey said in a university news release. "Pain is a complex, multidimensional experience, which causes activity in many ... Read more

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Narcotic Painkiller Use Tied to Higher Risk for Depression

Posted 20 Feb 2015 by Drugs.com

FRIDAY, Feb. 20, 2015 – High doses of powerful narcotic painkillers appear to be linked to a higher risk of depression in patients, new research finds. The study focuses on a class of prescription narcotic painkillers called opioids, which include drugs such as Oxycontin and Vicodin. While most people use the medicines to ease pain, widespread abuse of narcotic painkillers is also a growing concern. The new study involved 355 patients in Texas who reported low back pain at an initial medical visit and still had the pain one and two years later. Although the study couldn't prove cause-and-effect, people who used higher doses of narcotic painkillers to manage their pain were more likely to have an increase in depression, the researchers found. Learning more about the link between these painkillers and depression, along with what dosage might put patients at higher risk, "may inform ... Read more

Related support groups: Pain, Depression, Back Pain

Many Americans Face Pain, Depression in Their Final Year

Posted 2 Feb 2015 by Drugs.com

MONDAY, Feb. 2, 2015 – For a growing number of Americans, the final year of life is marked by pain, depression and other distressing symptoms, a new study finds. Experts said the study, published Feb. 2 in Annals of Internal Medicine, highlights disturbing shortcomings in the U.S. health care system. Researchers found that between 1998 and 2010, the number of Americans who suffered pain in their last year of life rose from 54 percent to 61 percent. Meanwhile, the prevalence of depression rose from 45 percent to 57 percent, while other symptoms – such as breathlessness, confusion, severe fatigue and incontinence – either increased or did not improve. "These findings are troubling," said senior researcher Dr. Karl Lorenz, of the Pardee RAND Graduate School and the University of California, Los Angeles. The increase in end-of-life symptoms, Lorenz said, has occurred despite national ... Read more

Related support groups: Pain, Depression

Zogenix Receives FDA Approval for New Abuse-Deterrent Formulation of Zohydro ER

Posted 30 Jan 2015 by Drugs.com

SAN DIEGO, Jan. 30, 2015 – Zogenix, Inc. (Nasdaq:ZGNX), a pharmaceutical company developing and commercializing products for the treatment of central nervous system (CNS) disorders, today announced that the U.S. Food and Drug Administration (FDA) has approved a new formulation of Zohydro ER (hydrocodone bitartrate) Extended-Release Capsules, CII, with BeadTek™. BeadTek is a formulation technology designed to provide abuse-deterrent properties without changing the release properties of hydrocodone when Zohydro ER is used as intended. Concurrently, Zogenix has ongoing Human Abuse Liability studies, which will further characterize the abuse-deterrent properties of the new formulation. Zogenix intends to submit these data in the second half of 2015 to the FDA to support an amended product label, including abuse-deterrent claims consistent with the FDA's current draft Guidance for Industry, ... Read more

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FDA Medwatch Alert: Prescription and Over-the-Counter (OTC) Pain Medicines: Drug Safety Communication - FDA Review of Possible Risks of Pain Medicine Use During Pregnancy

Posted 20 Jan 2015 by Drugs.com

[Posted 01/09/2015] ISSUE:  FDA is aware of and understands the concerns arising from recent reports questioning the safety of prescription and over-the-counter (OTC) pain medicines when used during pregnancy. As a result, FDA evaluated research studies published in the medical literature and determined they are too limited to make any recommendations based on these studies at this time. Because of this uncertainty, the use of pain medicines during pregnancy should be carefully considered. FDA urges pregnant women to always discuss all medicines with their health care professionals before using them. Severe and persistent pain that is not effectively treated during pregnancy can result in depression, anxiety, and high blood pressure in the mother. Medicines including nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, and acetaminophen can help treat severe and persistent pain. ... Read more

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Hospira Receives U.S. FDA Approval of Proprietary Analgesic Dyloject (diclofenac sodium) Injection

Posted 30 Dec 2014 by Drugs.com

LAKE FOREST, Ill., Dec. 30, 2014 /PRNewswire/ – Hospira, Inc. (NYSE: HSP), the world's leading provider of injectable drugs and infusion technologies, and a global leader in biosimilars, has received approval from the U.S. Food and Drug Administration (FDA) for Dyloject (diclofenac sodium) Injection, a proprietary nonsteroidal anti-inflammatory drug (NSAID) analgesic. Dyloject is indicated for use in adults for the management of mild to moderate pain and for the management of moderate to severe pain alone or in combination with opioid analgesics. "In today's healthcare environment, pain management and patient satisfaction are important to hospitals. As a result, various medical organizations are now recommending a multi-modal approach to pain control in an effort to minimize the use of opioids," said Sumant Ramachandra, M.D., Ph.D., senior vice president and chief scientific officer, ... Read more

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U.S. Doctors Cutting Back on Painkiller Prescriptions: Study

Posted 8 Dec 2014 by Drugs.com

MONDAY, Dec. 8, 2014 – Nine out of 10 primary care doctors in the United States are concerned about prescription drug abuse in their communities, a new study finds. And, nearly half of the physicians surveyed said they were less likely to prescribe powerful painkillers than they were just a year ago. Researchers surveyed 580 internists, family doctors and general practitioners across the country. They found that 85 percent of doctors believe that narcotic painkillers (opioids such as Oxycontin) are overused in clinical practice. Around half of those surveyed said they were "very concerned" about risks such as addiction, death and traffic crashes associated with narcotic painkiller overuse. Almost two-thirds of the doctors believe that tolerance to the drugs occurs often. Just over half believe that physical dependence is a common problem. And, the doctors said these issues can happen ... Read more

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FDA Approves Hysingla ER - Extended-Release Hydrocodone with Abuse-Deterrent Properties

Posted 25 Nov 2014 by Drugs.com

November 20, 2014 – The U.S. Food and Drug Administration today approved Hysingla ER (hydrocodone bitartrate), an extended-release (ER) opioid analgesic to treat pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate. Hysingla ER has approved labeling describing the product’s abuse-deterrent properties consistentwith the FDA’s 2013 draft guidance for industry, Abuse-Deterrent Opioids – Evaluation and Labeling. Hysingla ER has properties that are expected to reduce, but not totally prevent, abuse of the drug when chewed and then taken orally, or crushed and snorted or injected. The tablet is difficult to crush, break or dissolve. It also forms a viscous hydrogel (thick gel) and cannot be easily prepared for injection. The FDA has determined that the physical and chemical properties of Hysingla ER are ex ... Read more

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Abuse-Resistant Prescription Painkiller Approved

Posted 21 Nov 2014 by Drugs.com

THURSDAY, Nov. 20, 2014 – The U.S. Food and Drug Administration has approved Hysingla ER (hydrocodone bitartrate), an abuse-resistant, extended release form of the painkiller hydrocodone (best known as Vicodin). The drug is sanctioned for long-term severe pain that requires daily, around-the-clock treatment. The tablet is difficult to crush, break or dissolve, making it resistant to abuse, the agency said Thursday in a news release. But the medication can still be abused, and an overdose can lead to death, the FDA warned. Hysingla ER shouldn't be used for "as-needed" pain relief, the agency added. The drug's safety and effectiveness were evaluated in clinical studies involving 905 people with chronic lower-back pain. The most common side effects were constipation, nausea, fatigue, upper respiratory tract infection, dizziness and headache. The FDA said it has ordered a post-marketing ... Read more

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Pain, Depression Tied to Delirium Risk After Surgery for Seniors

Posted 11 Nov 2014 by Drugs.com

TUESDAY, Nov. 11, 2014 – Pain and depression before an operation may increase seniors' risk for delirium after surgery, a new study suggests. Rates of delirium after surgery are highest among older patients, occurring in up to 51 percent of those aged 65 and older. Previous research has also shown that depression is a major risk factor for delirium, which is a disoriented state marked by a sharp decrease in attention and mental abilities. This study included 459 patients without dementia, aged 70 and older, who had orthopedic surgery. The patients' pain and depression levels were assessed before surgery. Twenty-three percent of the patients experienced delirium after surgery, the investigators found. Delirium occurred much more often in patients who had depression and pain before surgery, according to the study published recently in The Lancet Psychiatry. Further analyses found that ... Read more

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FDA Medwatch Alert: Assured Brand Naproxen Sodium Tablets by Contract Packaging Resources, Inc.: Recall - Packaging Mix-Up

Posted 22 Oct 2014 by Drugs.com

ISSUE: Contract Packaging Resources, a drug repackaging company, is voluntarily recalling 11,640 boxes of Assured brand Naproxen Sodium tablets because some cartons actually contain bottles of Ibuprofen, a different pain reliever. The affected products are: boxes of Assured brand Naproxen Sodium Tablets 220mg, 15 count (Lot #FH4102A) [SKU #122368/UPC #639277223685] containing bottles of Ibuprofen softgels in 200mg strength. Consumers who intentionally avoid using Ibuprofen due to allergy, or other medical conditions, are advised that they may have inadvertently purchased Ibuprofen 200mg softgels, believing it was Naproxen Sodium 220mg tablets. Allergic reactions can range from mild irritation or hives to serious reactions such as anaphylaxes that may be life-threatening. The firm has not received any reports of adverse events related to this recall. BACKGROUND: The recalled Assured ... Read more

Related support groups: Pain, Naproxen, Aleve, Naprosyn, Naprelan, Naprelan '375', Anaprox, Midol Extended Relief, Anaprox-DS, EC-Naprosyn, Flanax Pain Reliever, Naprelan '500', Naproxen Sodium DS, Aflaxen

FDA Approves Labeling with Abuse-Deterrent Features for Embeda (morphine/naltrexone)

Posted 17 Oct 2014 by Drugs.com

October 17, 2014 – The U.S. Food and Drug Administration today approved new labeling for Embeda (morphine sulfate and naltrexone hydrochloride) extended-release (ER) capsules, an opioid analgesic to treat pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate. Embeda is the third ER opioid analgesic to be approved with labeling describing the product’s abuse-deterrent properties consistent with the FDA’s 2013 draft guidance, Abuse-Deterrent Opioids – Evaluation and Labeling. The new labeling includes a claim indicating that Embeda has properties that are expected to reduce oral abuse when the product is crushed. Embeda has properties that are expected to reduce, but not totally prevent, abuse of the drug when crushed and taken orally or snorted. Embeda works by releasing only the morphine in the capsu ... Read more

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Anesthetic During Breast-Removal Surgery May Reduce Long-Term Pain

Posted 13 Oct 2014 by Drugs.com

MONDAY, Oct. 13, 2014 – Giving a common local anesthetic to women undergoing breast removal surgery – a mastectomy – reduces their risk of persistent pain after the procedure, a new study says. More than two-thirds of mastectomy patients experience chronic pain after surgery, which can significantly affect physical activity, physical and mental health, and quality of life. The pain also increases the risk of depression, sleep problems and use of anti-anxiety drugs, according to the authors of the study. "Unfortunately, chronic pain is a condition that many breast cancer patients endure after mastectomy," said lead author Dr. Mohamed Tiouririne, associate professor of anesthesiology at the University of Virginia. "Our findings indicate that intravenous (IV) lidocaine can protect mastectomy patients from developing chronic pain, possibly due to the anti-inflammatory effects associated ... Read more

Related support groups: Pain, Surgery, Breast Cancer, Lidocaine, Xylocaine, Xylocaine Duo-Trach Kit, L-Caine, Xylocaine HCl For Spinal, Lidoject 2, Truxacaine, DentiPatch, Dilocaine, Xylocaine HCl, Lidoject 1, Xylocaine-MPF, Nervocaine, UAD Caine, Anestacaine

FDA Medwatch Alert: Ketorolac Tromethamine Injection, USP, 30mg/ml by Sagent Pharmaceuticals: Recall - Incorrect Labeling

Posted 6 Oct 2014 by Drugs.com

ISSUE: Sagent Pharmaceuticals, Inc. issued a voluntary nationwide recall of three lots (lot numbers: MP5021, MP5024 and MP5025) of Ketorolac Tromethamine Injection, USP, 30mg/mL single-dose vials (NDC numbers 25021-701-01 and 25021-701-02) manufactured by Cadila Healthcare Limited and distributed by Sagent. The affected product was labeled with the incorrect expiration date. The labeled expiration date is longer than the known stability of the product. BACKGROUND: Ketorolac Tromethamine Injection, USP, 30mg/mL is a nonsteroidal anti-inflammatory drug (NSAID) indicated for short-term management of moderately severe acute pain that requires analgesia at the opioid level, usually in a postoperative setting, and is supplied in a single-dose vial. The lot numbers being recalled  - MP5021, MP5024 and MP5025 - were distributed to hospitals, wholesalers and distributors nationwide from S ... Read more

Related support groups: Pain, Toradol, Ketorolac, Toradol IV/IM, Toradol IM, Sprix

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naltrexone, bupivacaine liposome, rofecoxib, pentafluoropropane / tetrafluoroethane, meclofenamate, morphine liposomal, aspirin / diphenhydramine, aspirin / codeine, acetaminophen / caffeine / phenyltoloxamine, acetaminophen / caffeine / phenyltoloxamine / salicylamide, acetaminophen / dextromethorphan, acetaminophen / caffeine / magnesium salicylate / phenyltoloxamine, acetaminophen / aspirin / caffeine / salicylamide, acetaminophen / aluminum hydroxide / aspirin / caffeine / magnesium hydroxide, acetaminophen / aspirin, acetaminophen / dextromethorphan / doxylamine, acetaminophen / diphenhydramine, aspirin / caffeine / dihydrocodeine, aspirin / caffeine / salicylamide, aspirin / carisoprodol / codeine, aluminum hydroxide / aspirin / calcium carbonate / magnesium hydroxide, alfentanil, acetaminophen / guaifenesin, acetaminophen / phenyltoloxamine / salicylamide, capsaicin / lidocaine / menthol / methyl salicylate, acetaminophen / magnesium salicylate, Tolectin 600, Mapap Children's, Children's Silapap, Tolectin DS, Numorphan, Infumorph, Percocet 7.5 / 500, Febrol Solution, EC-Naprosyn, Xylocaine Topical, Astramorph PF, Buffasal, Farbital, Medi-Seltzer, Duraclon, Capital w / Codeine, LMX 5, Lidosense 5, Duraxin, Tylophen, Genapap, Dolorex, acetaminophen / aspirin / diphenhydramine, naloxone / oxycodone, diphenhydramine / naproxen, Aceta w / Codeine, Mapap, Indocin SR, Oruvail, Combunox, IBU, Tylenol 8 Hour, Aspiritab, Remedol, Panamax 240, Zero-Order Release, YSP Aspirin, Aspirin Lite Coat, Acetylsalicylic Acid, Norwich Aspirin, Therapy Bayer, Stanback Analgesic, Duragesic-75, Ionsys, Morphine Rapi-Ject, Doloral, Doloral Sirop, Rescudose, Roxanol 100, Hydrostat IR, Duramorph PF, Bufferin Extra Strength, Entaprin, Empirin, Bayer Plus, Buffex, Halfprin, Sloprin, Tolectin, Vanatrip, Ecotrin Maximum Strength, Entercote, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Genprin, Gennin-FC, Extra Strength Bayer, Genacote, Morphitec, M-Oxy, Numorphan HCl, Magan, Mobidin, Rid-A-Pain, Outgro Pain Relief, LTA Pediatric Kit, LTA II Kit, Nuprin Backache Caplet, Vistazine, Dolorac, RT Capsin, Trixaicin HP, Sucrets, Wild Cherry, Sarna Ultra, Tronothane, Prax, LTA Preattached 360 Kit, Senatec, Lidomar, Xylocaine 10% Oral, Dermaflex, Anestacon, PP-Cap, ETH-Oxydose, Endocodone, Medi-Quik Spray, Protech First Aid Stik, LMX 4, Laryng-O-Jet Spray, LMX 4 with Tegaderm, LMX Plus, Ela-Max, Ela-Max 5, Mapap Rapid Tabs, Paralyoc, Pain Clear Paracetamol, Setamol, Paraspen Drops, Sigma Pain Relief, Pharmore Paracetamol, Panadol Gel Caps, Pacimol Caplets, Panadol Colourfree Drops, Pharmaction Paracetamol, Febridol Infant Drops, Accidental Rapatabs, Lemsip Headcold, Sigma Paracetamol, Paracetamol Soluble, Hexal Comfarol, Panadol Extend, Priceline Paracetamol, Paracare, Cuprofen for Children, Mandanol Infant, Mandanol 6+, Silapap Infants, Parmol, Parahexal, Febridol, Duatrol SR, Mapap Meltaway, Panadol Gel Tabs, Panadol Mini Caps, Pharmacist Paracetamol, Promax, Dymadon, Mapap Arthritis Pain, Paraspen, Lemsip Original, Bydol, Paracetamol Arrow, Paracetamol Biogaran, Paracetamol EG, Paracetamol Almus, Geluprane, Efferalganodis, Expandox, Paracetamol Ivax, Paracetamol Merck, Paracetamol Teva, Paracetamol Winthrop, Paracetamol Zydus, Paracetamol Sandoz, Paracetamol RPG, Paracetamol Qualimed, Paracetamol Ranbaxy, Efferalgan Pediatrique, Dolotec, Rex Paracetamol, Paineze Paracetamol, Panamol, Panadol Soluble, Panadol Rapid Handipak, Chem Mart Chemadol, Benylin Sore Throat, Tempol, Taminol, Dolko, Dolko Enfants, Dolitabs, Doliprane Sans Sucre, Doliprane, Doliprane Adultes, Capsin