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Coffee, Wine Good for Healthy Gut, Sodas May Be Bad

Posted 28 Apr 2016 by Drugs.com

THURSDAY, April 28, 2016 – The food you eat and the medicines you take can alter your gut bacteria in ways that either help or harm your health, two new studies suggest. Foods like fruits, vegetables, coffee, tea, wine, yogurt and buttermilk can increase the diversity of bacteria in a person's intestines. And that diversity can help ward off illness, said Dr. Jingyuan Fu, senior author of one of the studies. "It is believed that higher diversity and richness [in gut bacteria] is beneficial," explained Fu. She is an associate professor of genetics at the University of Groningen in the Netherlands. On the other hand, foods containing loads of simple carbohydrates appear to reduce bacterial diversity in the gut, Fu and colleagues found. These include high-fat whole milk and sugar-sweetened soda. In addition, medications can also play a part in the makeup of your gut bacteria. Antibiotics, ... Read more

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Metformin Safer for Heart Than Other Common Type 2 Diabetes Drugs: Study

Posted 18 Apr 2016 by Drugs.com

MONDAY, April 18, 2016 – Metformin, the most frequently prescribed standalone drug for type 2 diabetes, is better for the heart than its closest competitors, a large analysis suggests. Metformin reduced the risk of dying from heart attack and stroke by about 30 percent to 40 percent compared with other commonly used drugs called sulfonylureas, such as glibenclamide, glimepiride, glipizide and tolbutamide, researchers report. "Pharmaceutical companies continue to make new drugs to reduce blood sugar and improve on safety concerns of the older drugs," said senior study author Dr. Shari Bolen. But, "while adults with diabetes often need more than one medication to control blood sugar, the newer medications do not appear to be safer than the older drugs," added Bolen. Metformin is still the safest and most effective type 2 diabetes medication, said Bolen. She is an assistant professor of ... Read more

Related support groups: Diabetes, Type 2, Metformin, Glucophage, Glipizide, Janumet, Glimepiride, Amaryl, Glucophage XR, Prevention of Cardiovascular Disease, GlipiZIDE XL, Glucotrol, ActoPlus Met, Glucotrol XL, Cardiovascular Risk Reduction, Glumetza, Glyburide/Metformin, Janumet XR, Avandamet, Glucovance, Jentadueto

Widely Used Type 2 Diabetes Drug May Reduce Cancer Death Risk

Posted 15 Apr 2016 by Drugs.com

FRIDAY, April 15, 2016 – Metformin, a commonly prescribed diabetes drug, may reduce the risk of dying from some cancers for postmenopausal women with type 2 diabetes, a new study suggests. The study found that for women with type 2 diabetes and cancer, the odds of dying from cancer appeared to be 45 percent higher compared to women with cancer who didn't have diabetes. But, in women with cancer who took metformin to treat their type 2 diabetes, the risk of dying from cancer seemed about the same as it was for women without diabetes. "Our findings from this large study may provide more evidence that postmenopausal women with diabetes and cancer may benefit from metformin therapy compared to other anti-diabetes therapy," said lead researcher Zhihong Gong. She's an assistant professor of oncology at the Roswell Park Cancer Institute, in Buffalo, N.Y. Gong cautioned, however, that this ... Read more

Related support groups: Diabetes, Type 2, Cancer, Metformin, Glucophage, Janumet, Glucophage XR, ActoPlus Met, Breast Cancer, Prevention, Glumetza, Glyburide/Metformin, Janumet XR, Avandamet, Glucovance, Jentadueto, Metformin/Pioglitazone, Riomet, Fortamet, Kombiglyze XR, Metformin/Sitagliptin, ActosPlus Met

FDA Medwatch Alert: Metformin-containing Drugs: Drug Safety Communication - Revised Warnings for Certain Patients With Reduced Kidney Function

Posted 13 Apr 2016 by Drugs.com

ISSUE: FDA is requiring labeling changes regarding the recommendations for metformin-containing medicines for diabetes to expand metformin’s use in certain patients with reduced kidney function. The current labeling strongly recommends against use of metformin in some patients whose kidneys do not work normally. FDA was asked to review numerous medical studies regarding the safety of metformin use in patients with mild to moderate impairment in kidney function, and to change the measure of kidney function in the metformin drug labeling that is used to determine whether a patient can receive metformin. FDA concluded, from the review of studies published in the medical literature, that metformin can be used safely in patients with mild impairment in kidney function and in some patients with moderate impairment in kidney function. FDA is requiring changes to the metformin labeling to r ... Read more

Related support groups: Diabetes, Type 2, Metformin, Glucophage, Janumet, Glucophage XR, ActoPlus Met, Glumetza, Glyburide/Metformin, Janumet XR, Avandamet, Glucovance, Jentadueto, Metformin/Pioglitazone, Riomet, Kombiglyze XR, Fortamet, Glipizide/Metformin, Kazano, ActosPlus Met, PrandiMet

Diabetes Cases Quadruple Worldwide Since 1980: Report

Posted 6 Apr 2016 by Drugs.com

WEDNESDAY, April 6, 2016 – The number of adults worldwide with diabetes has quadrupled in the past 35 years, a new report shows. Climbing from 108 million in 1980 to 422 million in 2014, the increases were particularly severe in low- and middle-income countries such as China and India, the researchers noted. Global diabetes rates rose from just over 4 percent to 9 percent among men, and from 5 percent to almost 8 percent among women, the findings showed. The price tag for treating and managing the disease and its complications now totals $825 billion a year, the report found. "Diabetes has become a defining issue for global public health. An aging population, and rising levels of obesity, mean that the number of people with diabetes has increased dramatically," said senior study author Majid Ezzati, a professor at Imperial College, London. The statistics were not divided between type 1 ... Read more

Related support groups: Diabetes, Type 2, Obesity, Metformin, Weight Loss, Glucophage, Janumet, Insulin Resistance, Pre-Diabetes, Diabetes Mellitus, Glucophage XR, ActoPlus Met, Glumetza, Glyburide/Metformin, Janumet XR, Avandamet, Glucovance, Jentadueto, Metformin/Pioglitazone, Abnormal Glucose Tolerance, Riomet

Cost of Insulin Rises Threefold in Just a Decade: Study

Posted 5 Apr 2016 by Drugs.com

TUESDAY, April 5, 2016 – Americans with diabetes who rely on insulin to keep their blood sugar levels in check are facing sticker shock: A new study finds the price of insulin has tripled in only 10 years. Moreover, since 2010, per-person spending on insulin in the United States was more than spending on all other diabetes drugs, the study found. "The cost of insulin has risen rapidly over the last few years," said study senior author Philip Clarke, a professor of health economics at the University of Melbourne in Australia. Clarke added there should be an assessment to see whether this price hike is justifiable in terms of improved clinical outcomes. One reason for the price climb, he said, is a switch from human insulins to analog insulins, which cost more but may offer additional benefits. Also, doctors are more apt to prescribe insulin for people with type 2 diabetes now, Clarke ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Victoza, Lantus, Diabetes, Type 1, Januvia, Glucophage, Novolog, Humalog, Glipizide, Diabetic Neuropathy, Janumet, Byetta, Insulin Resistance, Diabetic Nerve Damage, Glyburide, Bydureon, Lantus Solostar, Actos

Diabetes Meds Vary in Safety and Effectiveness, Study Shows

Posted 31 Mar 2016 by Drugs.com

THURSDAY, March 31, 2016 – A study of nearly a half-million people with type 2 diabetes shows there are pros and cons to nearly every form of drug therapy for the disease. In the British study, researchers looked at patient outcomes from a large U.K. database of almost 470,000 adults with type 2 diabetes, tracked between 2007 and 2015. Julia Hippisley-Cox and Carol Coupland, of the University of Nottingham, sought to parse out differences among a variety of diabetes drugs. They accounted for complicating patient factors such as age, sex, smoking and poverty, as well as how long a person had been diagnosed with type 2 diabetes. The researchers also focused on five major outcomes linked to diabetes: blindness, amputation, severe kidney failure, and high or low blood sugar. Reporting March 30 in BMJ, they found that when a class of drugs called glitazones (Actos, Avandia) was prescribed ... Read more

Related support groups: Diabetes, Type 2, Metformin, Glucophage, Glipizide, Janumet, Insulin Resistance, Glyburide, Actos, Pre-Diabetes, Glimepiride, Amaryl, Diabetes Mellitus, Avandia, Glucophage XR, GlipiZIDE XL, Prandin, Glucotrol, ActoPlus Met, Glucotrol XL, Glumetza

Diabetes Drug May Not Help Obese Women Have Normal-Weight Babies

Posted 3 Feb 2016 by Drugs.com

WEDNESDAY, Feb. 3, 2016 – Giving the diabetes drug metformin to obese pregnant women may not help their newborns come into the world at a healthier weight, a new trial finds. The study, reported Feb. 4 in the New England Journal of Medicine, adds to evidence that metformin does not curb obese women's risk of having an abnormally large newborn. On the other hand, the British researchers found the drug did help control a woman's own weight gain during pregnancy. And it may slash the risk of a potentially dangerous complication called preeclampsia. "Those findings bring to light some potential benefits of metformin for these women," said Dr. Jerrie Refuerzo, an associate professor of obstetrics and gynecology at the University of Texas Health McGovern Medical School, in Houston. For now, diet and exercise will remain the mainstay of managing obesity during pregnancy, according to ... Read more

Related support groups: Diabetes, Type 2, Obesity, Metformin, Weight Loss, Glucophage, Janumet, Delivery, Glucophage XR, Vitamin/Mineral Supplementation during Pregnancy/Lactation, ActoPlus Met, Glumetza, Glyburide/Metformin, Janumet XR, Avandamet, Glucovance, Jentadueto, Metformin/Pioglitazone, Gestational Diabetes, Riomet, Fortamet

Diabetes Drug Improves Gut Bacteria, Study Finds

Posted 4 Dec 2015 by Drugs.com

FRIDAY, Dec. 4, 2015 – The diabetes drug metformin appears to trigger favorable changes in intestinal bacteria, a new study finds. Researchers analyzed the intestinal bacteria populations in 784 people with and without type 2 diabetes who lived in China, Denmark and Sweden. The results showed that taking metformin had positive effects on the intestinal bacteria of people with type 2 diabetes. Specifically, the drug improved the ability of the bacteria to produce certain types of short-chain fatty acids that reduce blood sugar levels in different ways. The researchers also found that patients who take metformin have more coliform bacteria in their intestines, which may explain why the drug causes side effects such as bloating and increased flatulence. "We weren't able to show that other types of antidiabetic drugs had any actual impact on the gut microbiota. When studying type 2 ... Read more

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Metformin May Not Help Obese Teens With Type 1 Diabetes

Posted 2 Dec 2015 by Drugs.com

TUESDAY, Dec. 1, 2015 – Metformin is the standby drug for millions of people with type 2 diabetes, but a new study finds that adding it to insulin therapy won't boost blood sugar control for overweight teens with type 1 diabetes. In type 1 diabetes, which comprises about 5 percent of diabetes cases, the body is unable to produce the insulin it needs. So, supplemental insulin is a must for people with the disease. The new study was led by Kellee Miller of the Jaeb Center for Health Research in Tampa, Fla. As her team explained, young people with type 1 diabetes are at even higher metabolic risk if they become overweight or obese, especially in adolescence. That's because both obesity and puberty may cause the patient to require higher levels of supplemental insulin, complicating blood sugar control, the researchers said. Metformin – a pill taken to help lower blood sugar – is widely ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Diabetes, Type 1, Glucophage, Diabetic Neuropathy, Janumet, Diabetic Nerve Damage, Pre-Diabetes, Diabetes Mellitus, Glucophage XR, ActoPlus Met, Glumetza, Glyburide/Metformin, Janumet XR, Avandamet, Glucovance, Jentadueto, Metformin/Pioglitazone, Riomet

New Diabetes Cases Among Americans Drop for First Time in Decades: CDC

Posted 1 Dec 2015 by Drugs.com

TUESDAY, Dec. 1, 2015 – In a sign that Americans may finally be turning the corner in the fight against diabetes – and possibly obesity – federal health statistics released Tuesday show that the number of new cases of diabetes has dropped for the first time in decades. The decline wasn't sudden or dramatic. But, the number of new diabetes cases went from 1.7 million in 2009 to 1.4 million in 2014, according to the U.S. Centers for Disease Control and Prevention. "It seems pretty clear that incidence rates have now actually started to drop. Initially it was a little surprising because I had become so used to seeing increases everywhere we looked," CDC researcher Edward Gregg told The New York Times. The proportion of Americans with diabetes is still twice what it was in the early 1990s. And not every racial group has made strides against the blood sugar disease, which is often ... Read more

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Too Many Seniors With Diabetes Are Overtreated, Study Suggests

Posted 29 Oct 2015 by Drugs.com

THURSDAY, Oct. 29, 2015 – When it comes to treating seniors with diabetes, new research suggests that doctors often don't cut back on medications, even when treatment goals are surpassed. The study found that when people had potentially dangerous low blood sugar levels, just 27 percent had their medicines decreased. And when blood pressure treatments lowered blood pressure levels too much, just 19 percent saw a reduction in their medications. "As people get older, the risks of overtreating become greater, and the benefits become shorter. We have to start emphasizing that more isn't always better," said study author Dr. Jeremy Sussman, an assistant professor of internal medicine at the University of Michigan in Ann Arbor and a primary care doctor at the Ann Arbor VA System. The findings were published online Oct. 26 in the journal JAMA Internal Medicine. Practice guidelines generally ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Victoza, Lantus, Januvia, Glucophage, Novolog, Humalog, Glipizide, Janumet, Byetta, Glyburide, Bydureon, Lantus Solostar, Actos, Levemir, Invokana, Glimepiride, Saxenda

Tight Control of Type 2 Diabetes May Help Prevent Dementia

Posted 15 Sep 2015 by Drugs.com

TUESDAY, Sept. 15, 2015 – Keeping blood sugar levels in check may have a protective effect against dementia in people who have type 2 diabetes, new Swedish research suggests. "The positive association between [average blood sugar levels] and risk of dementia in fairly young patients with type 2 diabetes indicates a potential for prevention of dementia with improved blood sugar control," study author Dr. Aidin Rawshani, from the National Diabetes Register and Institute of Medicine in Gothenburg, Sweden, and colleagues wrote. However, the study wasn't able to definitively prove a cause-and-effect relationship between blood sugar levels and dementia; it was only able to show an association between these factors. The study included almost 350,000 people with type 2 diabetes. They were all registered in the Swedish National Diabetes Registry between January 2004 and December 2012. They had ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Lantus, Dementia, Alzheimer's Disease, Glucophage, Novolog, Humalog, Glipizide, Janumet, Glyburide, Lantus Solostar, Actos, Levemir, Invokana, Glimepiride, Amaryl, Novolin R, Pioglitazone

FDA Warns of Joint Pain Tied to Common Type 2 Diabetes Drugs

Posted 31 Aug 2015 by Drugs.com

FRIDAY, Aug. 28, 2015 – Use of a class of widely prescribed medications for type 2 diabetes is tied to severe joint pain in some patients, the U.S. Food and Drug Administration warned on Friday. The drugs – sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta) and alogliptin (Nesina) – come from a newer class of medications called DPP-4 inhibitors. The drugs can be taken alone or used in conjunction with other diabetes drugs, such as metformin. DPP-4 inhibitors help fight type 2 diabetes by boosting the amount of insulin the body produces after each meal, when blood sugar levels are typically high. However, in a statement, the FDA said the medications "may cause joint pain that can be severe and disabling," and the agency "has added a new Warning and Precaution about this risk to the labels of all medicines in this drug class." The FDA stressed that patients who take ... Read more

Related support groups: Diabetes, Type 2, Metformin, Januvia, Glucophage, Janumet, Pre-Diabetes, Onglyza, Diabetes Mellitus, Tradjenta, Glucophage XR, Sitagliptin, ActoPlus Met, Glumetza, Glyburide/Metformin, Janumet XR, Avandamet, Glucovance, Jentadueto, Linagliptin, Glyxambi

Health Tip: Diabetes Can Take a Toll on Teeth and Mouth

Posted 10 Aug 2015 by Drugs.com

-- Diabetes, especially when uncontrolled, can cause damage to your mouth and teeth. The Mouthhealthy.org website says possible effects of diabetes on the teeth and mouth include: Dry mouth, due to decreased saliva production. Increased risk of cavities due to less saliva. Gingivitis, characterized by bleeding, inflamed gums. Difficulty tasting food. Slower healing of mouth wounds. Increased risk of infection. Among diabetic children. teeth emerging earlier than expected. Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Victoza, Oral and Dental Conditions, Xerostomia, Lantus, Toothache, Diabetes, Type 1, Januvia, Glucophage, Novolog, Humalog, Glipizide, Burning Mouth Syndrome, Diabetic Neuropathy, Janumet, Diabetic Nerve Damage, Byetta, Insulin Resistance

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