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FDA Approves Janumet XR (sitagliptin and metformin HCl extended-release) for Type 2 Diabetes, Offering the Powerful Efficacy of Janumet (sitagliptin/metformin HCl) Now Available with Once-Daily Convenience
Posted 2 Feb 2012 by Drugs.com
WHITEHOUSE STATION, N.J.--(BUSINESS WIRE)--Feb 2, 2012 - Merck, known as MSD outside the United States and Canada, announced today that the U.S. Food and Drug Administration (FDA) approved Janumet XR (sitagliptin and metformin hydrochloride (HCl) extended-release) tablets, a new treatment for type 2 diabetes that combines sitagliptin, which is the active component of Januvia (sitagliptin), with extended-release metformin. Janumet XR provides a convenient once-daily treatment option for healthcare providers and patients who need help to control their blood sugar. Janumet XR is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both sitagliptin and extended-release metformin is appropriate. Janumet XR should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis. Janumet ... Read more
Related support groups: Diabetes, Type 2, Metformin, Janumet, Sitagliptin, Metformin/Sitagliptin
Four Common Meds Send Thousands of Seniors to Hospital: CDC
Posted 23 Nov 2011 by Drugs.com
WEDNESDAY, Nov. 23 – An estimated 100,000 older Americans are hospitalized for adverse drug reactions yearly, and most of those emergencies stem from four common medications, a new study finds. The four types of medication – two for diabetes and two blood-thinning agents – account for two-thirds of those drug-related emergency hospitalizations. "Of the thousands of medications available to older patients, a small group of blood thinners and diabetes medications caused a high proportion of emergency hospitalizations for adverse drug events among elderly Americans," said lead study author Dr. Daniel Budnitz, director of the U.S. Centers for Disease Control and Prevention's medication safety program. Medications previously designated "high-risk" were implicated in only 1.2 percent of hospitalizations, the study found. Working with a nationally representative database, CDC researchers ... Read more
Related support groups: Metformin, Aspirin, Coumadin, Plavix, Warfarin, Insulin, Lantus, Januvia, Glucophage, Actos, Glyburide, Glipizide, Humalog, Janumet, Novolog
FDA Approves Redesigned Labels for Some Merck Drugs
Posted 13 Jun 2011 by Drugs.com
Changes developed under Merck's Label Standardization Project SILVER SPRING, Md., June 10, 2011 /PRNewswire-USNewswire/ – The U.S. Food and Drug Administration today is announcing the approval of Merck's redesigned drug container labels that include a new standardized format to improve readability and provide better information on product and strength differentiation. (Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO) Merck's Label Standardization Project includes the revision of 34 container labels for 16 solid oral drug products regulated by the FDA's Center for Drug Evaluation and Research (CDER). Drugs affected by the revisions include: Cozaar, Crixivan, Hyzaar, Isentress, Janumet, Januvia, Mevacor, Noroxin, Prinivil, Prinzide, Propecia, Proscar, Singulair, Zocor, and Zolinza. "We commend Merck for their efforts," said Janet Woodcock, M.D., director of CDER. "This was n ... Read more
Related support groups: Singulair, Januvia, Cozaar, Zocor, Hyzaar, Janumet, Propecia, Proscar, Prinzide, Prinivil, Noroxin, Mevacor, Isentress, Crixivan, Zolinza
Diabetes Drugs Might Lower Risk of Lung Cancer
Posted 3 Nov 2010 by Drugs.com
TUESDAY, Nov. 2 – Researchers report that drugs used to treat diabetes may indeed both prevent and contain lung cancer. The findings, being presented Tuesday at the annual meeting of the American College of Chest Physicians in Vancouver, back up preliminary data that some diabetes medications might protect against tobacco-induced lung cancer. "Patients who did not develop lung cancer had a much higher chance of taking one of these medications than those who did develop lung cancer," said study author Dr. Peter Mazzone. "And those who did develop lung cancer were much less likely to have seen that cancer spread outside the chest and more likely to survive longer with one of these drugs." Both metformin and the class of drugs known as thiazolidinediones (which includes Avandia and Actos) are used by tens of millions of Americans. A mouse study published in September found that metformin ... Read more
Related support groups: Metformin, Glucophage, Actos, Janumet, Lung Cancer, Avandia, Pioglitazone, Glucophage XR, ActoPlus Met, Avandamet, Glumetza, Metformin/Pioglitazone, Riomet, Glucovance, Glipizide/Metformin
Drug Combo Staves Off Type 2 Diabetes
Posted 2 Jun 2010 by Drugs.com
WEDNESDAY, June 2 – In people with pre-diabetes, a low-dose combination of two diabetes drugs – metformin and Avandia (rosiglitazone) – appeared to reduce the progression to type 2 diabetes, new research shows. The study found that the risk of developing type 2 diabetes was reduced by two-thirds in those taking the drug combo compared to those on placebo. "Diabetes is a complex metabolic disorder, and it's unlikely that there will ever be one magic bullet that treats or prevents diabetes," explained study author Dr. Bernard Zinman, director of the Leadership Sinai Centre for Diabetes at Mount Sinai Hospital and the University of Toronto. "So, more like treatments for HIV/AIDS or cancer that use a drug cocktail, we attempted to look at two drugs that have been known to have beneficial effects in diabetes." "We were pleasantly surprised to find that using half of the maximum dose was ... Read more
Related support groups: Metformin, Glucophage, Janumet, Pre-Diabetes, Avandia, Glucophage XR, ActoPlus Met, Avandamet, Glumetza, Metformin/Pioglitazone, Riomet, Glipizide/Metformin, Glucovance, Fortamet, ActosPlus Met
Common Diabetes Drug Linked to Vitamin B-12 Deficiency
Posted 22 May 2010 by Drugs.com
FRIDAY, May 21 – Diabetics who take the drug metformin over the long term should get their vitamin B-12 levels checked regularly to see if they are developing a vitamin deficiency, a new report suggests. Metformin, also known by several brand names including Glucophage, is a common treatment for people with type 2 diabetes, but it can cause vitamin B-12 deficiency, according to the report published online May 21 in the journal BMJ. Failing to check patients' vitamin levels may lead doctors to improperly diagnose the symptoms of B-12 deficiency, which include fatigue, mental changes, anemia and neuropathy. Doctors may mistakenly think these symptoms are caused by diabetes or aging, the study authors noted. Researchers in the Netherlands led by Coen Stehouwer studied the effects of metformin treatment on 390 patients with type 2 diabetes. They prescribed either the drug (196 patients) or ... Read more
Related support groups: Metformin, Glucophage, Janumet, Glucophage XR, ActoPlus Met, Avandamet, Glumetza, Riomet, Glucovance, Metformin/Pioglitazone, Fortamet, Glipizide/Metformin, Glyburide/Metformin, ActosPlus Met, Metformin/Sitagliptin
Diabetes Drugs Go Head-to-Head in Study
Posted 4 Dec 2009 by Drugs.com
THURSDAY, Dec. 3 – A class of drugs still taken by millions of people with type 2 diabetes is associated with a higher risk of dying and heart failure than the newer treatment metformin, researchers say. Sulfonylureas, long a mainstay of diabetes treatment, performed less well than metformin in a study of oral anti-diabetes drugs, but doctors said the findings aren't necessarily a reason to discontinue taking them. Glyburide, glipizide and glimepiride are examples of sulfonylureas. Metformin, which is sold as Glucophage and other brand names, is already the first-choice therapy for type 2 diabetes, and the findings are in line with new American Diabetes Association recommendations, meaning the results won't change the way patients are already treated. "This raises some interesting points for other, more specific research, but it won't affect the way we practice medicine tomorrow," said ... Read more
Related support groups: Diabetes, Type 2, Metformin, Glucophage, Actos, Glyburide, Glipizide, Janumet, Amaryl, Avandia, Glimepiride, Pioglitazone, Glucophage XR, GlipiZIDE XL, Glucotrol, ActoPlus Met