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Certain Painkillers Ill-Advised After Heart Attack: Study

Posted 10 days ago by Drugs.com

TUESDAY, Feb. 24, 2015 – Common painkillers such as ibuprofen and Celebrex may raise the risk for heart attack, stroke and/or serious bleeding among heart attack survivors taking prescription blood thinners, a new study says. The finding could prompt widespread concern, given that these painkillers – known as nonsteroidal anti-inflammatory drugs (NSAIDs) – and anti-clot medications are widely used by heart attack survivors, researchers said. "For all sorts of reasons, many of us have been concerned about NSAIDs in a heart attack context for a long time," said Dr. Charles Campbell, chief of cardiovascular medicine at the University of Tennessee Erlanger Health Systems in Chattanooga. "For example, we know NSAIDs have an adverse effect on the kidney. And we have long worried that what this study has found was going to be the case." There appeared to be no safe window period for taking ... Read more

Related support groups: Ibuprofen, Heart Disease, Naproxen, Heart Attack, Celebrex, Diclofenac, Advil, Voltaren, Aleve, Motrin, Myocardial Infarction, Flector, Naprosyn, Cataflam, Zipsor, Naprelan '375', Naprelan, Celecoxib, Cambia, Intracranial Hemorrhage

FDA Medwatch Alert: Prescription and Over-the-Counter (OTC) Pain Medicines: Drug Safety Communication - FDA Review of Possible Risks of Pain Medicine Use During Pregnancy

Posted 20 Jan 2015 by Drugs.com

[Posted 01/09/2015] ISSUE:  FDA is aware of and understands the concerns arising from recent reports questioning the safety of prescription and over-the-counter (OTC) pain medicines when used during pregnancy. As a result, FDA evaluated research studies published in the medical literature and determined they are too limited to make any recommendations based on these studies at this time. Because of this uncertainty, the use of pain medicines during pregnancy should be carefully considered. FDA urges pregnant women to always discuss all medicines with their health care professionals before using them. Severe and persistent pain that is not effectively treated during pregnancy can result in depression, anxiety, and high blood pressure in the mother. Medicines including nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, and acetaminophen can help treat severe and persistent pain. ... Read more

Related support groups: Pain, Tylenol, Acetaminophen, Ibuprofen, Naproxen, Advil, Aleve, Paracetamol, Motrin, Panadol, Naprosyn, Naprelan '375', Naprelan, Panadol Osteo, Tylenol Extra Strength, Q-Pap, Childrens Tylenol, Acetaminophen Quickmelt, Anaprox, Tylenol Arthritis Caplet

Study Rates Migraine Medications

Posted 20 Jan 2015 by Drugs.com

TUESDAY, Jan. 20, 2015 – The best medications to use if you suffer migraine headaches are listed in a new study. Researchers reviewed recent scientific literature and concluded that a number of classes of drugs were effective for treating acute migraine. These include triptans, dihydroergotamine (DHE) and many NSAIDS (nonsteroidal anti-inflammatory drugs that include aspirin, ibuprofen and naproxen). Also on the list: butorphanol nasal spray, and the combination medications sumatriptan/naproxen and acetaminophen/aspirin/caffeine. Several other medications are "probably effective" or "possibly effective," according to the study in the January issue of the journal Headache. While powerful opioid pain drugs such as butorphanol, codeine/acetaminophen and tramadol/acetaminophen are likely effective migraine treatments, they are not recommended for regular use, the researchers said. The ... Read more

Related support groups: Migraine, Aspirin, Ibuprofen, Naproxen, Meloxicam, Migraine Prevention, Diclofenac, Advil, Voltaren, Mobic, Aleve, Imitrex, Motrin, Excedrin, Toradol, Indomethacin, Migraine Prophylaxis, Maxalt, Etodolac, Sumatriptan

Knee Arthritis Drugs Beat Placebos, but Study Finds No Clear Winner

Posted 6 Jan 2015 by Drugs.com

TUESDAY, Jan. 6, 2015 – Pain-relieving treatments for knee arthritis all work better than doing nothing – but it's hard to point to a clear winner, a new research review concluded. Using data from almost 140 studies, researchers found all of the widely used arthritis treatments – from over-the-counter painkillers to pain-relieving injections – brought more relief to aching knees over three months than did placebo pills. But there were some surprises in the study, according to lead researcher Dr. Raveendhara Bannuru, of Tufts Medical Center in Boston. Overall, the biggest benefit came from injections of hyaluronic acid (HA) – a treatment some professional medical groups consider only marginally effective. Hyaluronic acid is a lubricating substance found naturally in the joints. Over the years, studies have been mixed as to whether injections of synthetic HA help arthritic joints, ... Read more

Related support groups: Osteoarthritis, Tylenol, Acetaminophen, Ibuprofen, Naproxen, Meloxicam, Diclofenac, Advil, Voltaren, Mobic, Aleve, Paracetamol, Cortisone, Motrin, Toradol, Indomethacin, Etodolac, Nabumetone, Orthovisc, Flector

Common Painkillers May Help Prevent Certain Skin Cancers, Study Finds

Posted 18 Dec 2014 by Drugs.com

THURSDAY, Dec. 18, 2014 – Common painkillers, including ibuprofen, might slightly reduce your risk of developing a form of skin cancer, researchers say. Use of ibuprofen (Advil, Motrin) and naproxen (Aleve) appear to reduce the risk of squamous cell skin cancer by 15 percent, the researchers concluded after reviewing nine prior studies. Squamous cell skin cancer is usually caused by sun exposure. These painkillers "have potential as part of a skin cancer-prevention strategy," said review co-author Catherine Olsen, a senior research officer with QIMR Berghofer Medical Research Institute in Brisbane, Queensland, Australia. But Olsen and other experts aren't ready to recommend popping these or other nonsteroidal anti-inflammatory drugs (NSAIDs) to prevent skin cancer. For one thing, these drugs are associated with risks of their own. "Don't rely on aspirin or other nonsteroidal ... Read more

Related support groups: Ibuprofen, Naproxen, Advil, Aleve, Motrin, Vicoprofen, Skin Cancer, Naprosyn, Advil PM, Vimovo, Advil Cold and Sinus, Treximet, Squamous Cell Carcinoma, Naprelan '375', Naprelan, Anaprox, Hydrocodone/Ibuprofen, Duexis, Dristan Sinus, Rufen

Some Painkillers Tied to Bleeding Risk in Those With Abnormal Heartbeat

Posted 17 Nov 2014 by Drugs.com

MONDAY, Nov. 17, 2014 – People with the abnormal heartbeat known as atrial fibrillation who take common painkillers might significantly increase their risk for bleeding and blood clots, according to a new study. That risk was even higher among patients who took a blood thinner along with one of these nonsteroidal anti-inflammatory painkiller drugs (NSAIDs), which include aspirin, ibuprofen (Motrin), naproxen (Aleve) and celecoxib (Celebrex). "If you add NSAIDs on top of blood-thinning medication, you double the risk of bleeding," said lead researcher Dr. Gunnar Gislason, from the Danish Heart Foundation in Copenhagen. Many people with atrial fibrillation take blood thinners to reduce the risk of stroke, he noted. Atrial fibrillation causes the upper chambers of the heart to contract quickly and irregularly. These abnormal contractions allow blood to pool in the heart, forming clots ... Read more

Related support groups: Aspirin, Ibuprofen, Naproxen, Meloxicam, Atrial Fibrillation, Celebrex, Diclofenac, Advil, Voltaren, Mobic, Aleve, Motrin, Toradol, Indomethacin, Etodolac, Nabumetone, Flector, Ketorolac, Arthrotec, Naprosyn

For a Child's Fracture, Use Ibuprofen, Not Morphine: Study

Posted 27 Oct 2014 by Drugs.com

MONDAY, Oct. 27, 2014 – For children with broken bones, ibuprofen is a better choice for pain relief than morphine, researchers report. Although both medications are effective in easing the pain associated with these injuries, oral morphine carries more risk for negative side effects, Canadian researchers found. "Evidence suggests that orally administered morphine and other [narcotic painkillers] are increasingly being prescribed," the researchers wrote. "However, evidence for the oral administration of morphine in acute pain management is limited. Thus, additional studies are needed to address this gap in knowledge and provide a scientific basis for outpatient analgesic choices in children." Broken bones account for up to one-quarter of all injuries involving children, the researchers said. The first two days after this type of injury are the most painful. Children have limited ... Read more

Related support groups: Morphine, Ibuprofen, Advil, MS Contin, Motrin, Kadian, Fracture, bone, Avinza, M O S, Roxanol, MSIR, Morphine IR, MS/S, Morphine Sulfate ER, Oramorph SR, Statex, Nuprin, Advil Migraine, Ibuprofen PMR, M-Eslon

Common Painkillers Tied to Blood Clot Risk, Study Suggests

Posted 24 Sep 2014 by Drugs.com

WEDNESDAY, Sept. 24, 2014 – People who use painkillers called nonsteroidal anti-inflammatory drugs (NSAIDs) – which include aspirin, naproxen (Aleve) and ibuprofen (Advil, Motrin) – may be at increased risk for potentially deadly blood clots, a new study suggests. But the study only showed an association between use of the painkillers and higher clotting risk; it did not prove cause-and-effect. The researchers analyzed the results of six studies involving more than 21,000 cases of a type of blood clot called a venous thromboembolism (VTE). These clots include deep vein thrombosis (a clot in the leg) and pulmonary embolism (a clot in the lungs). Reporting online Sept. 24 in Rheumatology, the analysis found that people who used NSAIDs had an 80 percent higher risk for venous clots. "Our results show a statistically significant increased VTE risk among NSAID users. Why NSAIDs may ... Read more

Related support groups: Aspirin, Ibuprofen, Naproxen, Advil, Deep Vein Thrombosis (DVT), Aleve, Motrin, Pulmonary Embolism, Deep Vein Thrombosis, Naprosyn, Ecotrin, Vioxx, Naprelan '375', Naprelan, Bayer Aspirin, Anaprox, Bufferin, Rufen, Ibuprofen PMR, Motrin Childrens

Painkillers May Halve Risk of Breast Cancer Return in Obese Women: Study

Posted 14 Aug 2014 by Drugs.com

THURSDAY, Aug. 14, 2014 – Obese women who have battled breast cancer might halve their chances of a recurrence if they take aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) regularly, new research suggests. The researchers followed 440 breast cancer survivors – most of them past menopause and overweight or obese – who were diagnosed between 1987 and 2011. The women had estrogen receptor-positive breast cancer, which requires the hormone estrogen to grow. Over the seven-year follow-up, taking the pain medications was linked to a difference in recurrence: "Twelve percent of those not taking NSAIDs had a recurrence, but 6 percent of those taking the drugs did," said study author Linda deGraffenried, an associate professor of nutritional sciences at the University of Texas in Austin. Of the 440 women, 159 used painkillers and 281 did not. Most of those using painkillers ... Read more

Related support groups: Obesity, Aspirin, Ibuprofen, Naproxen, Breast Cancer, Meloxicam, Diclofenac, Advil, Voltaren, Mobic, Aleve, Motrin, Toradol, Indomethacin, Etodolac, Nabumetone, Flector, Ketorolac, Arthrotec, Naprosyn

FDA Medwatch Alert: Ibuprofen and Oxcarbazepine Tablets by American Health Packaging: Recall - Mislabeled Packaging

Posted 21 Jul 2014 by Drugs.com

ISSUE: American Health Packaging (AHP) voluntarily recalled Lot #142588, Expiration Date, 01/2016 of Ibuprofen Tablets, USP, 600 mg, in a hospital unit dose presentation that may contain individual blistered doses labeled as Oxcarbazepine Tablets, 300 mg, lot #142544. In addition, AHP voluntarily recalled Oxcarbazepine Tablets, 300 mg, lot #142544, Expiration Date, 02/2016. This recall is the result of mislabeled inner unit dose blister packaging which could result in patients receiving ibuprofen and missing their scheduled dose of oxcarbazepine. Failure to receive the proper dose of oxcarbazepine could increase the chances of having a seizure. Inadvertent consumption of ibuprofen may cause adverse reactions in a number of patients in which use of ibuprofen is contraindicated BACKGROUND: Oxcarbazepine is used for treating certain types of seizures in patients with epilepsy. Cartons of ... Read more

Related support groups: Ibuprofen, Advil, Trileptal, Motrin, Oxcarbazepine, Motrin Childrens, Advil Migraine, Nuprin, Rufen, Advil Liqui-Gels, Ibuprofen PMR, Midol IB, Q-Profen, Ibu-6, Motrin Infant Drops, Motrin IB, Children's Motrin, Genpril, IBU-200, Caldolor

More Painkillers May Raise Heart Risks for Older Women: Review

Posted 8 Jul 2014 by Drugs.com

TUESDAY, July 8, 2014 – A category of painkillers that includes the popular over-the-counter drug naproxen (Aleve) might increase an older woman's risk of heart attack or stroke, researchers report. Doctors already knew that nonsteroidal anti-inflammatory drugs (NSAIDs) that target and inhibit the so-called "cox-2 enzyme" can raise a person's heart attack risk. This new study found the same sort of heart risks accompany NSAIDs that don't specifically target cox-2, but still inhibit the enzyme to some degree. That category of NSAIDs was associated with a 17 percent increase in postmenopausal women's risk of heart attack or stroke, compared to a 13 percent increase associated with NSAIDs that specifically target and inhibit cox-2. "These are widely used drugs in this country and worldwide, so it has huge ramifications," said study author Dr. Anthony Bavry, an associate professor of ... Read more

Related support groups: Ibuprofen, Naproxen, Meloxicam, Diclofenac, Advil, Voltaren, Mobic, Aleve, Motrin, Toradol, Indomethacin, Etodolac, Nabumetone, Flector, Ketorolac, Arthrotec, Naprosyn, Relafen, Lodine, Ketoprofen

Certain Prescription Painkillers Tied to Higher Risk of Irregular Heartbeat: Study

Posted 9 Apr 2014 by Drugs.com

WEDNESDAY, April 9, 2014 – A long-term study suggests that older people who use common prescription painkillers, including prescription-strength ibuprofen, may be increasing their risk for developing a type of irregular heartbeat called atrial fibrillation. Atrial fibrillation increases the risk of stroke and heart failure and can shorten life. Previous studies have also linked these painkillers – called nonsteroidal anti-inflammatory drugs, or NSAIDs – to a risk of heart attack and stroke, the researchers noted. Although this study is only able to show an association between prescription NSAIDs and the risk for atrial fibrillation, lead researcher Dr. Bruno Stricker, a professor of pharmacoepidemiology at Erasmus Medical Center in Rotterdam, the Netherlands, said he believes that this link "suggests a cause-effect relationship." However, one U.S. expert believes more research is ... Read more

Related support groups: Ibuprofen, Atrial Fibrillation, Advil, Motrin, Motrin Childrens, Advil Migraine, Nuprin, Rufen, Advil Liqui-Gels, Ibuprofen PMR, Midol IB, Q-Profen, Ibu-6, Motrin Infant Drops, Motrin IB, Children's Motrin, Genpril, IBU-200, Cap-Profen, Advil Junior Strength

FDA Advisers Revisit Heart Risks Posed by Painkillers

Posted 10 Feb 2014 by Drugs.com

MONDAY, Feb. 10, 2014 – Naproxen – the key pain reliever in Aleve – seems safer for the heart than other popular anti-inflammatory drugs such as ibuprofen (Advil and Motrin), U.S. health officials say. And it's possible that labeling will soon reflect that finding. Advisers to the U.S. Food and Drug Administration are meeting Monday and Tuesday to discuss cardiac risks associated with non-steroidal anti-inflammatory drugs, sometimes called NSAIDs. Millions of people take these medicines, which also include the prescription drug Celebrex, to relieve muscle aches, headaches and pain from arthritis and injuries. Since 2005, labeling laws have required a heart warning on these anti-inflammatory drugs. That stemmed from Merck's withdrawal of the NSAID Vioxx from the market in 2004 because of a notable increased risk of heart attack among Vioxx users. But naproxen doesn't seem to carry the ... Read more

Related support groups: Pain, Ibuprofen, Naproxen, Advil, Aleve, Motrin, Naprosyn, Naprelan, Naprelan '375', Anaprox, Advil Migraine, Midol IB, Motrin Childrens, Nuprin, Advil Liqui-Gels, Ibuprofen PMR, Rufen, Midol Extended Relief, Children's Motrin, Motrin IB

Certain Blood Proteins Higher in People Prone to Outbursts of Rage

Posted 18 Dec 2013 by Drugs.com

WEDNESDAY, Dec. 18, 2013 – Recurrent, unwarranted blow-ups such as road rage may have a biological basis, according to a new study. Blood tests of people who display the hostile outbursts that characterize a psychiatric illness known as intermittent explosive disorder show signs of inflammation, researchers say. "What we show is that inflammation markers [proteins] are up in these aggressive individuals," said Dr. Emil Coccaro, professor and chair of psychiatry and behavioral neuroscience at the University of Chicago. Currently, medication and behavior therapy are used to treat intermittent explosive disorder, which affects about 16 million Americans, according to the U.S. National Institute of Mental Health. But these methods are effective in fewer than 50 percent of cases, the study authors noted. Coccaro now wants to see if anti-inflammatory medicines can reduce both unwarranted ... Read more

Related support groups: Ibuprofen, Naproxen, Meloxicam, Diclofenac, Advil, Voltaren, Mobic, Aleve, Motrin, Toradol, Indomethacin, Etodolac, Nabumetone, Flector, Ketorolac, Arthrotec, Naprosyn, Relafen, Lodine, Ketoprofen

Always Ask a Vet Before Giving Painkillers to Pets, Expert Says

Posted 7 Nov 2013 by Drugs.com

THURSDAY, Nov. 7 – When people feel pain, they often reach for common medicines such as aspirin or Motrin. These types of drugs, known as NSAIDs, also are used to treat arthritis pain in dogs and to manage pain after surgery in dogs and cats. But NSAID use in pets carries risks as well as benefits. And all dogs and cats should have a thorough physical exam by a veterinarian – including a review of the pet's medical history – before being given NSAIDs , according to the U.S. Food and Drug Administration. Pet owners also need to be informed about possible side effects, including those that could signal danger. Some of the most common side effects of NSAIDs (nonsteroidal anti-inflammatory drugs) in animals reported to the FDA are vomiting, loss of appetite, reduced levels of activity and diarrhea. While your pet is taking NSAIDs, watch for these side effects as well as looking for blood ... Read more

Related support groups: Pain, Ibuprofen, Naproxen, Meloxicam, Diclofenac, Advil, Voltaren, Mobic, Aleve, Motrin, Toradol, Indomethacin, Etodolac, Nabumetone, Flector, Ketorolac, Arthrotec, Naprosyn, Relafen, Lodine

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