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HIV Infection Blog

Related terms: Acquired Immune Deficiency Syndrome, Acquired Immunodeficiency Syndrome (AIDS), Acute HIV Infection, Acute Retroviral Syndrome, AIDS, AIDS-Related Complex, Chronic Symptomatic HIV Infection, HIV Infection, Acute, HIV Seroconversion Syndrome, Human Immunodeficiency Virus Infection, Primary HIV Infection, HIV, ARC, Acquired Immunodeficiency Syndrome, HIV/AIDS

Antibody Holds Promise as Weapon Against HIV

Posted 10 days ago by Drugs.com

WEDNESDAY, April 8, 2015 – Therapy with a human antibody appears to reduce levels of the HIV virus in the blood for at least a month, preliminary research suggests. Antibodies are the part of the immune system that develop to fight infections. Use of these antibodies as a treatment is called immunotherapy. The antibody "might be able to intensify current treatment strategies," said study co-author Dr. Florian Klein an assistant professor of clinical investigation at Rockefeller University in New York City, especially since this new treatment appears to be more potent than previous attempts at HIV immunotherapy. The researchers acknowledged that this antibody treatment would have to be combined with HIV drugs or another antibody. And much more research is needed before this treatment could even be used as an add-on therapy. The current study represents just the first level of three ... Read more

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HIV Can Damage Brain Early On, Study Says

Posted 16 days ago by Drugs.com

THURSDAY, April 2, 2015 – HIV can spread to and develop in people's brains in the early stages of infection, new research shows. The findings highlight the need for screening and early treatment of infection with HIV, the virus that causes AIDS, the researchers said. "Any delay runs the risk that the virus could find refuge and cause damage in the brain, where some medications are less effective, potentially enabling it to re-emerge, even after it is suppressed in the periphery," said Dianne Rausch, director of the division of AIDS research at the U.S. National Institute of Mental Health (NIMH). The researchers compared evidence of HIV activity in samples of blood and spinal fluid from 72 untreated HIV-infected patients. The investigators found that 10 percent to 22 percent of the patients showed evidence of HIV replication or inflammation – which suggests an active infectious process ... Read more

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HIV Patients May Fare as Well as Others With Kidney Transplants

Posted 19 Mar 2015 by Drugs.com

THURSDAY, March 19, 2015 – Kidney transplant patients with HIV have similar survival rates as those without HIV, a new study finds. The study included 510 HIV-positive adults who had kidney transplants in the United States between 2002 and 2011. Overall, these patients had similar five- and 10-year survival rates as kidney transplant patients without HIV. However, transplant recipients who had both HIV and hepatitis C had lower survival rates than those without HIV: 69 percent versus 75 percent after five years, and 50 percent versus 54 percent after 10 years, the study found. About 25 percent of kidney transplant patients with HIV also have hepatitis C, according to the study published March 19 in the Journal of the American Society of Nephrology. The findings suggest that excellent results are possible among HIV-positive kidney transplant recipients. However, doctors should be ... Read more

Related support groups: HIV Infection, Renal Transplant

Herpes Drug Might Help Control Spread of HIV, Too

Posted 17 Mar 2015 by Drugs.com

TUESDAY, March 17, 2015 – A widely used herpes drug also seems to help people with the HIV virus, even if those people don't also have herpes, a new small study found. The researchers said their findings challenge the belief that drug Valtrex (valacyclovir) requires the presence of herpes to benefit people with HIV-1. HIV is the virus that causes AIDS. The study included 18 HIV patients in Peru. When patients took Valtrex twice daily for two weeks, they had decreases in HIV-1 levels. Patients taking a placebo saw their HIV levels go up. Experts thought that Valtrex worked against HIV by reducing inflammation caused by the herpes virus. This would give the HIV virus fewer active immune cells to attack, reducing the spread of the virus. But the drug doesn't depend on reducing inflammation to work against HIV, said study co-senior author Dr. Michael Lederman, a professor of medicine at ... Read more

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Half of Known Strains of HIV Originated in Gorillas

Posted 3 Mar 2015 by Drugs.com

MONDAY, March 2, 2015 – Since HIV first appeared in humans in the early 1980s, scientists have been laboring to discover where and how the AIDS-causing virus first developed. Now, an international team of researchers says it has confirmed that two of the four known groups of HIV strains affecting humans originated in western lowland gorillas in Africa. HIV-1 has four known groups, M, N, O and P, explained a team led by Martine Peeters, of the University of Montpellier in France. According to the researchers, prior studies have shown that groups M and N originated in chimpanzees in southern Cameroon. This new study shows that groups O and P originated in western lowland gorillas in Cameroon, the team reported March 2 in the Proceedings of the National Academy of Sciences. Although all four subtypes of HIV can infect humans, only one – Group M, found in Cameroon chimps – eventually ... Read more

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Taking Pill Before, After Sex Cuts HIV Infection for Gay Men: Study

Posted 25 Feb 2015 by Drugs.com

WEDNESDAY, Feb. 25, 2015 – There's new evidence that gay men not infected with HIV can stay that way if they take a pill called Truvada in the days before and after a sexual encounter with an infected partner. The strategy is known as "pre-exposure prophylaxis," or PrEP. Prior studies had suggested that chronic, daily use of Truvada (a combo pill of tenofovir plus emtricitabine) could slash rates of HIV transmission in partners where one person was already infected and the other was not. Now, two new studies – one from Britain and one jointly conducted in France and Canada – appear to bolster those results. They were presented Tuesday at the annual Conference on Retroviruses and Opportunistic Infections in Seattle. The British investigation, called PROUD, involved 500 gay men and seems to reconfirm the effectiveness of standard, once-a-day PrEP. That study found that this dosing ... Read more

Related support groups: HIV Infection, Pre-Exposure Prophylaxis, Truvada

Most HIV Infections Come From Undiagnosed or Untreated People: Study

Posted 23 Feb 2015 by Drugs.com

MONDAY, Feb. 23, 2015 – If an American becomes infected with HIV, chances are he or she contracted the virus from someone who didn't know they were infected or wasn't getting proper treatment. That's the message of a new U.S. study, which found that undiagnosed and untreated people with HIV may be responsible for more than nine out of 10 new infections. The findings "highlight the community-wide prevention benefits of expanding HIV diagnosis and treatment in the United States," a team led by Dr. Jacek Skarbinski, of the U.S. Centers for Disease Control and Prevention, wrote in the report. Looking at 2009 data, Skarbinski's team said that about 45,000 new cases of HIV were transmitted that year, adding to the total of more than 1.1 million Americans who were already living with HIV, the virus that causes AIDS. Using national databases, the investigators estimated that more than 18 ... Read more

Related support groups: HIV Infection, Pre-Exposure Prophylaxis

Some HIV Strains Cause Early Damage to Immune System, Study Finds

Posted 19 Feb 2015 by Drugs.com

THURSDAY, Feb. 19, 2015 – Fast-replicating strains of HIV damage the immune system in the very early stages of infection, resulting in quicker disease progression, a new study says. The results confirmed previous findings that people with faster-replicating HIV strains have a quicker decline in levels of infection-fighting immune system CD4 T-cells, the researchers reported in the Proceedings of the National Academy of Sciences. "These results reinforce our previous findings suggesting that interventions that affect [HIV)] replicative capacity can not only impact disease progression, but also the efficiency of transmission to other people," senior study author Eric Hunter, co-director of Emory University's Center for AIDS Research in Atlanta, said in a university news release. The finding is independent of viral load and whether patients have certain gene variants that boost immune ... Read more

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Doctors Pinpoint Why Child Who Appeared Free of HIV Suffered Relapse

Posted 18 Feb 2015 by Drugs.com

WEDNESDAY, Feb. 18, 2015 – HIV hid deep inside a young Mississippi girl born with the virus who suffered a disappointing relapse last July, after more than two years in which she appeared to have been cured by early, aggressive drug treatment, her doctors report. They now know that the girl's HIV was dormant all that time – not simply percolating undetected – because tests have shown that her recurring virus was an exact match to her mother's HIV, said the girl's pediatrician, Dr. Hannah Gay, of the University of Mississippi Medical Center, in Jackson. "It appears that the virus had been dormant all of those many months and years, because there's no evidence of diversity that would have been detected if low-level viral activity had been going on," she explained. Despite the setback, Gay and her colleagues believe that all babies born with HIV should receive the same rapid medical ... Read more

Related support groups: HIV Infection, Reduction of Perinatal Transmission of HIV

Kidneys From HIV Donors May Be OK for HIV Patients, Study Finds

Posted 11 Feb 2015 by Drugs.com

WEDNESDAY, Feb. 11, 2015 – New research from South Africa suggests that HIV may not be a barrier for kidney transplants between people infected with the virus that causes AIDS. The findings are good news for HIV-positive patients who worry about getting kidneys from others infected with the virus. The research doesn't appear likely to have an immediate impact in the United States, where HIV infection isn't as common and kidney disease is often treated with dialysis instead of transplants, experts noted. But in South Africa, "using HIV-positive donors might resolve some of the problems we are all experiencing in getting enough donors for our patients with end-stage kidney disease," said study author Dr. Elmi Muller, head of transplantation at Groote Schuur Hospital in Capetown. The revolution in treatment of HIV and AIDS is extending the lives of infected patients in South Africa as it ... Read more

Related support groups: HIV Infection, Organ Transplant

FDA Approves Dutrebis (lamivudine and raltegravir) for HIV-1 Infection

Posted 10 Feb 2015 by Drugs.com

February 6, 2015 – The United States Food and Drug Administration (FDA) has approved Dutrebis, a fixed dose combination tablet containing 150 mg of lamivudine and 300 mg of raltegravir. Dutrebis tablet is approved for use in combination with other antiretroviral products for the treatment of HIV-1 infection in adults and pediatric patients greater than or equal to 6 years of age weighing at least 30 kg. The recommended dosage of Dutrebis is one tablet taken twice daily with or without food. Dutrebis approval was based on an open-label, single dose, randomized, two-period, crossover study in healthy subjects (n=108). One Dutrebis fixed dose combination table was shown to provide comparable lamivudine and raltegravir exposures to one Epivir 150 mg tablet plus on Isentress 400 mg tablet. Due to the higher bioavailability of raltegravir contained in Dutrebis, the exposures provided by the ... Read more

Related support groups: HIV Infection, Lamivudine, Raltegravir

Blacks Account for More Than Half of New HIV Diagnoses: CDC

Posted 5 Feb 2015 by Drugs.com

THURSDAY, Feb. 5, 2015 – Blacks are diagnosed with HIV more often than any other group of Americans, and while their death rate from the disease is declining, it is still higher than in other racial/ethnic group. Those are the findings of two new U.S. government studies reported Thursday. The findings show the need to redouble efforts to provide black Americans with better HIV prevention, diagnosis and care, the researchers, from the Centers for Disease Control and Prevention (CDC), said. The first study involved an analysis of data from CDC-funded HIV testing in 61 regions across the country in 2013. Blacks accounted for 45 percent of people tested for HIV, the largest proportion of any racial/ethnic group. Blacks also accounted for nearly 55 percent of all new HIV diagnoses. Among blacks diagnosed with HIV, gay men accounted for about 37 percent of the new diagnoses, according to the ... Read more

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Smartphone Device Detects HIV, Syphilis

Posted 4 Feb 2015 by Drugs.com

WEDNESDAY, Feb. 4, 2015 – A smartphone accessory that can detect HIV and syphilis has been developed by Columbia University researchers. The low-cost device can spot markers of the infectious diseases from a finger prick of blood in 15 minutes. It's the first smartphone accessory that replicates all the functions of a laboratory-based blood test, according to the researchers. The device was tested by health care workers in Rwanda who used it to analyze blood samples from 96 patients. The health care workers were given 30 minutes of training on the device, and 97 percent of the patients had a positive response to the device. The findings were published Feb. 4 in the journal Science Translational Medicine. "Our work shows that a full laboratory-quality immunoassay can be run on a smartphone accessory," team leader Samuel Sia, an associate professor of biomedical engineering at Columbia ... Read more

Related support groups: HIV Infection, Syphilis, Diagnosis and Investigation

FDA Approves Prezcobix (darunavir and cobicistat) for HIV-1 Infection in Adults

Posted 29 Jan 2015 by Drugs.com

TITUSVILLE, N.J., Jan. 29, 2015 /PRNewswire/ – Janssen Therapeutics, Division of Janssen Products, LP (Janssen), today announced the U.S. Food and Drug Administration (FDA) has approved Prezcobix (darunavir 800 mg/cobicistat 150 mg) tablets, an HIV-1 protease inhibitor combined with a CYP3A4 inhibitor, for the treatment of human immunodeficiency virus (HIV-1) in combination with other antiretroviral agents for treatment-naive and treatment-experienced adults with no darunavir resistance-associated substitutions.[1] Prezcobix is a once-daily, fixed-dose antiretroviral combination tablet containing 800 mg of darunavir, marketed as PREZISTA® in the United States, and 150 mg of cobicistat, a pharmacokinetic enhancer or "boosting" agent, developed and marketed as Tybost® by Gilead Sciences, Inc., taken orally with other HIV-1 medications and with food. "Additional options remain an i ... Read more

Related support groups: HIV Infection, Cobicistat, Darunavir

FDA Approves Evotaz (atazanavir and cobicistat) for HIV-1 Infection in Adults

Posted 29 Jan 2015 by Drugs.com

PRINCETON, N.J. – January 29, 2015 --(BUSINESS WIRE)--Bristol-Myers Squibb Company (NYSE:BMY) announced today that the U.S. Food and Drug Administration (FDA) has approved Evotaz (atazanavir 300 mg and cobicistat 150 mg) tablets in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults. Evotaz is coformulated to be one pill, once-daily, combining the protease inhibitor atazanavir, which is marketed as Reyataz (atazanavir 200 mg/300 mg) capsules, and cobicistat, a pharmacokinetic enhancer marketed by Gilead Sciences, Inc. Today’s approval offers patients living with HIV an innovative treatment option that delivers proven suppression (HIV-1 RNA 70mL/min, a mean baseline plasma HIV-1 RNA of 4.8 log10 copies/mL, and a mean baseline CD4+ cell count of 352 cells/mm. At 48 weeks, 85% of patients in the Evotaz arm achieved HIV-1 RNA levels of Read more

Related support groups: HIV Infection, Atazanavir, Cobicistat

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