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Related terms: Acquired Immune Deficiency Syndrome, Acquired Immunodeficiency Syndrome (AIDS), Acute HIV Infection, Acute Retroviral Syndrome, AIDS, AIDS-Related Complex, Chronic Symptomatic HIV Infection, HIV Infection, Acute, HIV Seroconversion Syndrome, Human Immunodeficiency Virus Infection, Primary HIV Infection, HIV, ARC, Acquired Immunodeficiency Syndrome, HIV/AIDS

Global Trial Finds HIV Drugs Should Be Taken Right After Diagnosis

Posted 1 day 17 hours ago by

WEDNESDAY, May 27, 2015 – People with HIV should start taking medications to battle the virus that causes AIDS as soon as they're diagnosed, a new international study finds. Scientists involved in the trial were so impressed by the health benefits of early use of HIV drugs that they shut the study down early so they could offer the medications to all participants. The findings could alter World Health Organization guidelines about the best way to treat people with HIV, experts said. Currently, WHO recommends that HIV patients not start treatment until their immune system show signs of weakening. "We now have clear-cut proof that it is of significantly greater health benefit to an HIV-infected person to start antiretroviral therapy sooner rather than later," Dr. Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases, said in a statement. "Moreover, ... Read more

Related support groups: HIV Infection, Harvoni, Atripla, Tamiflu, Incivek, Truvada, Baraclude, Victrelis, Complera, Stribild, Tenofovir, Oseltamivir, Viread, Kaletra, Norvir, Telaprevir, Entecavir, Lamivudine, Lexiva, Boceprevir

Hundreds With HIV Could Donate Organs to Others With HIV: Study

Posted 16 days ago by

THURSDAY, May 14, 2015 – Nearly 400 HIV-positive potential organ donors in the United States could donate organs each year to HIV-positive people waiting for transplants, a new study estimates. "The findings are significant because there are not enough organ donors in the United States to meet the needs of all of the patients who might benefit from life-saving organ transplants," senior author Dr. Emily Blumberg, a professor in the infectious diseases division at the University of Pennsylvania's Perelman School of Medicine in Philadelphia, said in a university news release. "Some of the patients waiting for organs are infected with HIV but never make it to transplant because they either die while waiting or become too sick to be transplanted. HIV patients who undergo transplantation generally do well, so it is important to continue to look for ways to improve access to transplantation ... Read more

Related support groups: HIV Infection, Organ Transplant

Experimental AIDS Vaccine Targets Hidden Virus

Posted 29 Apr 2015 by

WEDNESDAY, April 29, 2015 – Preliminary research suggests that an AIDS vaccine in development can ramp up the body's immune system, boosting the response to medications HIV-positive patients take. Years of research will be required to confirm that the vaccine works, and researchers don't yet have the major funding needed to continue and push the experimental vaccine toward the market. Still, there's tremendous potential, said study senior author Dr. Barbara Ensoli, director of the National AIDS Center at the National Institute of Health in Rome, Italy. "Although the results are from infected patients, the vaccine may be suitable for both healthy and HIV-infected patients," said Ensoli. So far, she said, the vaccine appears to be well tolerated, with no signs of significant side effects. A vaccine has long been the holy grail of research into AIDS and HIV, the virus that causes the ... Read more

Related support groups: HIV Infection, Harvoni, Atripla, Incivek, Truvada, Baraclude, Victrelis, Complera, Stribild, Tenofovir, Viread, Kaletra, Norvir, Telaprevir, Entecavir, Lamivudine, Lexiva, Efavirenz, Boceprevir, Nevirapine

Drug-Related HIV Outbreak Spurs Nationwide Alert

Posted 24 Apr 2015 by

FRIDAY, April 24, 2014 – With narcotic painkiller abuse now linked to 142 cases of HIV in rural Indiana, U.S. health officials are alerting other states to watch for clusters of HIV and hepatitis C among injection drug users. The Scott County epidemic is "a powerful reminder that people who inject drugs are at high risk for both HIV and hepatitis," said Dr. Jonathan Mermin, director of the National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention. HIV, the AIDS-causing virus, "can gain ground at any time unless we remain vigilant about prevention, testing and care," he said during a Friday morning news conference. There is no indication that HIV infection among injection drug users is spreading beyond this area of Indiana, he said. "But it will be critical to examine all available data on the state and local level to assess whether HIV is increasing among injection drug ... Read more

Related support groups: Hepatitis C, HIV Infection, Toxic Reactions Incl Drug and Substance Abuse

Antibody Holds Promise as Weapon Against HIV

Posted 8 Apr 2015 by

WEDNESDAY, April 8, 2015 – Therapy with a human antibody appears to reduce levels of the HIV virus in the blood for at least a month, preliminary research suggests. Antibodies are the part of the immune system that develop to fight infections. Use of these antibodies as a treatment is called immunotherapy. The antibody "might be able to intensify current treatment strategies," said study co-author Dr. Florian Klein an assistant professor of clinical investigation at Rockefeller University in New York City, especially since this new treatment appears to be more potent than previous attempts at HIV immunotherapy. The researchers acknowledged that this antibody treatment would have to be combined with HIV drugs or another antibody. And much more research is needed before this treatment could even be used as an add-on therapy. The current study represents just the first level of three ... Read more

Related support groups: HIV Infection

HIV Can Damage Brain Early On, Study Says

Posted 2 Apr 2015 by

THURSDAY, April 2, 2015 – HIV can spread to and develop in people's brains in the early stages of infection, new research shows. The findings highlight the need for screening and early treatment of infection with HIV, the virus that causes AIDS, the researchers said. "Any delay runs the risk that the virus could find refuge and cause damage in the brain, where some medications are less effective, potentially enabling it to re-emerge, even after it is suppressed in the periphery," said Dianne Rausch, director of the division of AIDS research at the U.S. National Institute of Mental Health (NIMH). The researchers compared evidence of HIV activity in samples of blood and spinal fluid from 72 untreated HIV-infected patients. The investigators found that 10 percent to 22 percent of the patients showed evidence of HIV replication or inflammation – which suggests an active infectious process ... Read more

Related support groups: HIV Infection

HIV Patients May Fare as Well as Others With Kidney Transplants

Posted 19 Mar 2015 by

THURSDAY, March 19, 2015 – Kidney transplant patients with HIV have similar survival rates as those without HIV, a new study finds. The study included 510 HIV-positive adults who had kidney transplants in the United States between 2002 and 2011. Overall, these patients had similar five- and 10-year survival rates as kidney transplant patients without HIV. However, transplant recipients who had both HIV and hepatitis C had lower survival rates than those without HIV: 69 percent versus 75 percent after five years, and 50 percent versus 54 percent after 10 years, the study found. About 25 percent of kidney transplant patients with HIV also have hepatitis C, according to the study published March 19 in the Journal of the American Society of Nephrology. The findings suggest that excellent results are possible among HIV-positive kidney transplant recipients. However, doctors should be ... Read more

Related support groups: HIV Infection, Renal Transplant

Herpes Drug Might Help Control Spread of HIV, Too

Posted 17 Mar 2015 by

TUESDAY, March 17, 2015 – A widely used herpes drug also seems to help people with the HIV virus, even if those people don't also have herpes, a new small study found. The researchers said their findings challenge the belief that drug Valtrex (valacyclovir) requires the presence of herpes to benefit people with HIV-1. HIV is the virus that causes AIDS. The study included 18 HIV patients in Peru. When patients took Valtrex twice daily for two weeks, they had decreases in HIV-1 levels. Patients taking a placebo saw their HIV levels go up. Experts thought that Valtrex worked against HIV by reducing inflammation caused by the herpes virus. This would give the HIV virus fewer active immune cells to attack, reducing the spread of the virus. But the drug doesn't depend on reducing inflammation to work against HIV, said study co-senior author Dr. Michael Lederman, a professor of medicine at ... Read more

Related support groups: HIV Infection, Valtrex

Half of Known Strains of HIV Originated in Gorillas

Posted 3 Mar 2015 by

MONDAY, March 2, 2015 – Since HIV first appeared in humans in the early 1980s, scientists have been laboring to discover where and how the AIDS-causing virus first developed. Now, an international team of researchers says it has confirmed that two of the four known groups of HIV strains affecting humans originated in western lowland gorillas in Africa. HIV-1 has four known groups, M, N, O and P, explained a team led by Martine Peeters, of the University of Montpellier in France. According to the researchers, prior studies have shown that groups M and N originated in chimpanzees in southern Cameroon. This new study shows that groups O and P originated in western lowland gorillas in Cameroon, the team reported March 2 in the Proceedings of the National Academy of Sciences. Although all four subtypes of HIV can infect humans, only one – Group M, found in Cameroon chimps – eventually ... Read more

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Taking Pill Before, After Sex Cuts HIV Infection for Gay Men: Study

Posted 25 Feb 2015 by

WEDNESDAY, Feb. 25, 2015 – There's new evidence that gay men not infected with HIV can stay that way if they take a pill called Truvada in the days before and after a sexual encounter with an infected partner. The strategy is known as "pre-exposure prophylaxis," or PrEP. Prior studies had suggested that chronic, daily use of Truvada (a combo pill of tenofovir plus emtricitabine) could slash rates of HIV transmission in partners where one person was already infected and the other was not. Now, two new studies – one from Britain and one jointly conducted in France and Canada – appear to bolster those results. They were presented Tuesday at the annual Conference on Retroviruses and Opportunistic Infections in Seattle. The British investigation, called PROUD, involved 500 gay men and seems to reconfirm the effectiveness of standard, once-a-day PrEP. That study found that this dosing ... Read more

Related support groups: HIV Infection, Pre-Exposure Prophylaxis, Truvada

Most HIV Infections Come From Undiagnosed or Untreated People: Study

Posted 23 Feb 2015 by

MONDAY, Feb. 23, 2015 – If an American becomes infected with HIV, chances are he or she contracted the virus from someone who didn't know they were infected or wasn't getting proper treatment. That's the message of a new U.S. study, which found that undiagnosed and untreated people with HIV may be responsible for more than nine out of 10 new infections. The findings "highlight the community-wide prevention benefits of expanding HIV diagnosis and treatment in the United States," a team led by Dr. Jacek Skarbinski, of the U.S. Centers for Disease Control and Prevention, wrote in the report. Looking at 2009 data, Skarbinski's team said that about 45,000 new cases of HIV were transmitted that year, adding to the total of more than 1.1 million Americans who were already living with HIV, the virus that causes AIDS. Using national databases, the investigators estimated that more than 18 ... Read more

Related support groups: HIV Infection, Pre-Exposure Prophylaxis

Some HIV Strains Cause Early Damage to Immune System, Study Finds

Posted 19 Feb 2015 by

THURSDAY, Feb. 19, 2015 – Fast-replicating strains of HIV damage the immune system in the very early stages of infection, resulting in quicker disease progression, a new study says. The results confirmed previous findings that people with faster-replicating HIV strains have a quicker decline in levels of infection-fighting immune system CD4 T-cells, the researchers reported in the Proceedings of the National Academy of Sciences. "These results reinforce our previous findings suggesting that interventions that affect [HIV)] replicative capacity can not only impact disease progression, but also the efficiency of transmission to other people," senior study author Eric Hunter, co-director of Emory University's Center for AIDS Research in Atlanta, said in a university news release. The finding is independent of viral load and whether patients have certain gene variants that boost immune ... Read more

Related support groups: HIV Infection

Doctors Pinpoint Why Child Who Appeared Free of HIV Suffered Relapse

Posted 18 Feb 2015 by

WEDNESDAY, Feb. 18, 2015 – HIV hid deep inside a young Mississippi girl born with the virus who suffered a disappointing relapse last July, after more than two years in which she appeared to have been cured by early, aggressive drug treatment, her doctors report. They now know that the girl's HIV was dormant all that time – not simply percolating undetected – because tests have shown that her recurring virus was an exact match to her mother's HIV, said the girl's pediatrician, Dr. Hannah Gay, of the University of Mississippi Medical Center, in Jackson. "It appears that the virus had been dormant all of those many months and years, because there's no evidence of diversity that would have been detected if low-level viral activity had been going on," she explained. Despite the setback, Gay and her colleagues believe that all babies born with HIV should receive the same rapid medical ... Read more

Related support groups: HIV Infection, Reduction of Perinatal Transmission of HIV

Kidneys From HIV Donors May Be OK for HIV Patients, Study Finds

Posted 11 Feb 2015 by

WEDNESDAY, Feb. 11, 2015 – New research from South Africa suggests that HIV may not be a barrier for kidney transplants between people infected with the virus that causes AIDS. The findings are good news for HIV-positive patients who worry about getting kidneys from others infected with the virus. The research doesn't appear likely to have an immediate impact in the United States, where HIV infection isn't as common and kidney disease is often treated with dialysis instead of transplants, experts noted. But in South Africa, "using HIV-positive donors might resolve some of the problems we are all experiencing in getting enough donors for our patients with end-stage kidney disease," said study author Dr. Elmi Muller, head of transplantation at Groote Schuur Hospital in Capetown. The revolution in treatment of HIV and AIDS is extending the lives of infected patients in South Africa as it ... Read more

Related support groups: HIV Infection, Organ Transplant

FDA Approves Dutrebis (lamivudine and raltegravir) for HIV-1 Infection

Posted 10 Feb 2015 by

February 6, 2015 – The United States Food and Drug Administration (FDA) has approved Dutrebis, a fixed dose combination tablet containing 150 mg of lamivudine and 300 mg of raltegravir. Dutrebis tablet is approved for use in combination with other antiretroviral products for the treatment of HIV-1 infection in adults and pediatric patients greater than or equal to 6 years of age weighing at least 30 kg. The recommended dosage of Dutrebis is one tablet taken twice daily with or without food. Dutrebis approval was based on an open-label, single dose, randomized, two-period, crossover study in healthy subjects (n=108). One Dutrebis fixed dose combination table was shown to provide comparable lamivudine and raltegravir exposures to one Epivir 150 mg tablet plus on Isentress 400 mg tablet. Due to the higher bioavailability of raltegravir contained in Dutrebis, the exposures provided by the ... Read more

Related support groups: HIV Infection, Lamivudine, Raltegravir

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