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Related terms: Cholesteremia, Cholesterol, Elevated Levels, Cholesterol, High, Cholesterolemia, Familial Hypercholesterolemia, Hypercholesterolemia, Hypercholesterolemia, Familial, Hyperlipidemia, Lipid Metabolism Disorders

New Drug Class Slashes 'Bad' Cholesterol, Review Finds

Posted 10 hours ago by Drugs.com

MONDAY, April 27, 2015 – A new class of cholesterol drug could sharply cut "bad" LDL cholesterol in people who don't fare well on commonly used cholesterol-lowering medications called statins, a new research review confirms. The drugs, known as PCSK9 inhibitors, are not on the market yet. But the U.S. Food and Drug Administration (FDA) is expected to decide later this year on the first two medications in the class: evolocumab (Repatha) and alirocumab (Praluent). The review of 24 clinical trials found that PCSK9 inhibitors lowered people's LDL cholesterol by about 47 percent, on average. More important, the drugs seemed to cut the risk of heart attack or death from heart disease, according to the researchers. Experts did urge some caution, however: Trials so far have been short-term, and it's not clear whether the new cholesterol drugs really do extend people's lives, according to Dr. ... Read more

Related support groups: High Cholesterol, Niacin, Niaspan, High Cholesterol - Familial Heterozygous, Prevention of Cardiovascular Disease, High Cholesterol - Familial Homozygous, Slo-Niacin, Niaspan ER, Cardiovascular Risk Reduction, Vascepa, Cardiovascular Conditions and Disorders, Nicotinic Acid, Choloxin, Niacin SR, Nicotinex, Mipomersen, Niacor B3, B3-500-Gr, Nico-400, Lorelco

New Guidelines Would Greatly Boost Number of Young People on Statins

Posted 6 Apr 2015 by Drugs.com

MONDAY, April 6, 2015 – If all doctors followed new cholesterol guidelines aimed at children, almost half a million Americans aged 17 to 21 would be prescribed a cholesterol-lowering statin drug, a new study predicts. In 2011, the U.S. National Heart, Lung, and Blood Institute (NHLBI) issued new guidelines on reducing heart disease in adolescents and young adults. Those guidelines recommended that all people aged 17 to 21 get their blood levels of cholesterol checked, and statin treatment be initiated if cholesterol was at a certain level. In contrast, the American College of Cardiology (ACC) and American Heart Association (AHA) are sticking by adult-focused guidelines that more tightly restrict the use of statins for those under 40 years age. In the new study, researchers led by Dr. Holly Gooding of Boston Children's Hospital looked at data from more than 6,300 participants, aged 17 ... Read more

Related support groups: High Cholesterol, Hypertriglyceridemia, High Cholesterol - Familial Heterozygous, High Cholesterol - Familial Homozygous, Hyperlipoproteinemia Type IIa (Elevated LDL), Hyperlipoproteinemia, Hyperlipoproteinemia Type IIb (Elevated LDL + VLDL), Hyperlipoproteinemia Type III (Elevated beta-VLDL + IDL), Hyperlipoproteinemia Type IV (Elevated VLDL), Hyperlipoproteinemia Type V (Elevated Chylomicrons + VLDL)

Kids' Bad Diets May Mean Worse Health as Adults

Posted 17 Mar 2015 by Drugs.com

TUESDAY, March 17, 2015 – The overall heart health of U.S. children falls short, a new analysis suggests. Northwestern University researchers found that while most of the nearly 9,000 children they studied had healthy blood pressure levels, 40 percent did not have good cholesterol levels, almost none ate a healthy diet regularly and 30 percent were overweight or obese. These findings may mean more children will face a future that will include heart disease if nothing changes, said Dr. Sarah Samaan, a cardiologist at Legacy Heart Center in Plano, Texas. "Childhood sets the stage for life. If a child starts off with a healthy diet and active lifestyle, he or she is far less likely to develop chronic, expensive diseases that can take years off of a productive life," said Samaan, who was not involved with the study. "Obese kids and adults are far more likely to develop high blood pressure, ... Read more

Related support groups: Obesity, Weight Loss, High Cholesterol

Experimental Drug Shows Promise in Lowering Cholesterol, Heart Attack Risk

Posted 15 Mar 2015 by Drugs.com

SUNDAY, March 15, 2015 – Adding an experimental new biologic drug to conventional cholesterol-lowering drugs may result in better cholesterol control and reduced risks of heart attack and stroke, according to a new study. Compared to patients on conventional therapy alone, those who also got the experimental drug evolocumab were half as likely to die, suffer a heart attack or a stroke or be in the hospital to have a procedure to open blocked arteries during the one-year follow-up, said lead researcher Dr. Marc Sabatine. The combined therapy ''basically halves the rate of cardiovascular events," said Sabatine, a senior physician in cardiovascular medicine at Brigham and Women's Hospital in Boston. "It's a very impressive risk reduction," added Sabatine, who's due to present the study findings Sunday at the American College of Cardiology annual meeting in San Diego. The findings were ... Read more

Related support groups: High Cholesterol, Cardiovascular Risk Reduction

Poor Response to Statins May Mean Clogged Arteries

Posted 26 Feb 2015 by Drugs.com

THURSDAY, Feb. 26, 2015 – Twenty percent of people with heart disease don't respond to cholesterol-lowering statins and may have dangerously clogged arteries, researchers have found. A new study found these people experienced little or no reduction in the "bad" cholesterol that contributes to artery-blocking plaque, making heart attack or stroke more likely. The finding has important implications for statin guidelines, said lead researcher Dr. Stephen Nicholls, deputy director of the South Australian Health & Medical Research Institute in Adelaide. "Cholesterol levels should continue to be monitored to ensure we are moving in the right direction," said Nicholls. "It is simply not good enough to prescribe [a statin] and move on." The analysis also underscores the need for new medications to target plaque buildup in statin nonresponders, the study said. Nicholls said many patients – ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Pravastatin, Atorvastatin, Zocor, Lovastatin, Rosuvastatin, Red Yeast Rice, Livalo, Pravachol, Cardiovascular Risk Reduction, Hyperlipoproteinemia, Lescol, Lescol XL, Mevacor, Pitavastatin, Altoprev, Fluvastatin

Prolonged High Cholesterol in Middle Age Raises Heart Risk Later: Study

Posted 26 Jan 2015 by Drugs.com

MONDAY, Jan. 26, 2015 – Many folks in their 30s and 40s chow down on burgers, fried chicken and other fatty foods without fear, figuring they have years before they need to worry about their cholesterol levels. But new research reveals that long-term exposure to even slightly higher cholesterol levels can damage a person's future heart health. People at age 55 who've lived with 11 to 20 years of high cholesterol showed double the risk of heart disease compared to people that age with only one to 10 years of high cholesterol, and quadruple the risk of people who had low cholesterol levels, researchers report online Jan. 26 in the journal Circulation. "The duration of time a person has high cholesterol increases a person's risk of heart disease above and beyond the risk posed by their current cholesterol level," said study author Dr. Ann Marie Navar-Boggan, a cardiology fellow at the ... Read more

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Number of Americans Taking Statins Keeps Rising: CDC

Posted 23 Dec 2014 by Drugs.com

TUESDAY, Dec. 23, 2014 – More Americans than ever are taking cholesterol-lowering medications, federal health officials reported Tuesday. The percentage of adults aged 40 and older taking drugs that combat high cholesterol rose from 20 percent to 28 percent between 2003 and 2012, according to the U.S. Centers for Disease Control and Prevention. Moreover, the use of statins increased from 18 percent to 26 percent, making them most commonly used cholesterol-lowering drugs. By 2011-12, 93 percent of adults using a cholesterol-lowering medication used a statin. The CDC researchers said they couldn't speculate on the reasons for the increase. But one cardiologist pointed out that statins have been shown to lower the risk of heart attack, stroke and premature death in men and women at risk for heart disease and stroke. And "heart disease and stroke remain the leading cause of illness and ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Pravastatin, Atorvastatin, Zocor, Lovastatin, Rosuvastatin, Red Yeast Rice, Livalo, Pravachol, Cardiovascular Risk Reduction, Lescol, Lescol XL, Mevacor, Fluvastatin, Altoprev, Pitavastatin, Baycol

Most Seniors Could Use Statins Under New Guidelines

Posted 24 Nov 2014 by Drugs.com

MONDAY, Nov. 24, 2014 – Most older Americans qualify for treatment with cholesterol-lowering statins under new guidelines intended to reduce the risk of heart attack or stroke, a new study shows. Guidelines for the treatment of blood cholesterol released late last year by the American College of Cardiology and the American Heart Association target people most likely to benefit from taking statins such as Zocor (simvastatin) and Crestor (rosuvastatin). The new study of more than 6,000 black and white Americans aged 66 to 90 found that 70 percent were eligible for statin therapy, including 97 percent of those aged 66 to 75 and all of the men. The findings appear in a research letter published Nov. 24 in the journal JAMA Internal Medicine. "The guidelines are a significant change from prior guidelines that relied heavily on levels of bad cholesterol to determine who to treat," letter ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Pravastatin, Atorvastatin, Zocor, Lovastatin, Rosuvastatin, Red Yeast Rice, Livalo, Pravachol, Cardiovascular Risk Reduction, Lescol, Lescol XL, Mevacor, Fluvastatin, Altoprev, Pitavastatin, Baycol

Experimental Cholesterol-Lowering Drug Effective, Study Reports

Posted 17 Nov 2014 by Drugs.com

MONDAY, Nov. 17, 2014 – An experimental antibody drug could prove effective at lowering LDL ("bad") cholesterol levels for patients who have side effects with cholesterol-lowering statin medications. That's the conclusion of a clinical trial presented Monday at the American Heart Association annual meeting in Chicago. The drug, alirocumab, outperformed the on-the-market medication that is currently the most widely used alternative to statins, Zetia, said lead researcher Dr. Patrick Moriarty, director of clinical pharmacology at the University of Kansas Medical Center. Researchers from the drug's developers – Sanofi and Regeneron Pharmaceuticals – were also involved in the current study. Patients taking alirocumab had a 45 percent decrease in their LDL cholesterol levels. Those taking Zetia went down by just 14.6 percent, Moriarty reported. One drawback to the new medication, however, ... Read more

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High Cholesterol Tied to Prostate Cancer's Return in Study

Posted 10 Oct 2014 by Drugs.com

FRIDAY, Oct. 10, 2014 – After surgery for prostate cancer, elevated levels of cholesterol and triglycerides may be linked with greater risk of the cancer's return, a new study suggests. In a review of more than 800 men who had had their prostate gland removed, those with higher levels of these two blood fats were more likely to have their cancer come back, compared with men with normal levels. "These findings suggest that normalization, or even partial normalization, of blood fats among men with high cholesterol and triglycerides may reduce the risk of prostate cancer recurrence," said lead researcher Emma Allott, a postdoctoral associate at Duke University School of Medicine. Cholesterol levels can be modified by diet or use of drugs called statins, she said. Allott's team also found that increases in high-density lipoprotein (HDL), the "good" cholesterol, benefited some men. For ... Read more

Related support groups: High Cholesterol, Prostate Cancer

Older Patients More Likely to Fill Prescriptions for Generic Statins: Study

Posted 15 Sep 2014 by Drugs.com

MONDAY, Sept. 15, 2014 – Patients prescribed cholesterol-lowering drugs are more likely to fill their prescriptions and gain health benefits if the medications are cheaper generic brands, new research suggests. At issue are the cholesterol-lowering drugs known as statins. Well-known brands include Crestor, Zocor and Lipitor. Generic statins are also available. The drugs are designed to lower the risk of heart problems due to clogged arteries. About half of patients on statins stop taking them within the first year, explained study lead author Joshua Gagne, an assistant professor of medicine with Brigham and Women's Hospital and Harvard Medical School in Boston. Statins are among the most "notorious" medications in terms of low adherence – patients actually taking them when they're prescribed, said Dr. Orli Etingin, a professor of clinical medicine at Weill Cornell Medical College-New ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Pravastatin, Atorvastatin, Zocor, Lovastatin, Rosuvastatin, Red Yeast Rice, Livalo, Pravachol, Cardiovascular Risk Reduction, Lescol, Lescol XL, Mevacor, Fluvastatin, Altoprev, Pitavastatin, Baycol

Statins May Help Kids With Genetic Cholesterol Disorder

Posted 9 Sep 2014 by Drugs.com

TUESDAY, Sept. 9, 2014 – Cholesterol-lowering statin drugs seem to help reduce the risk of cardiovascular disease in children who have a genetic cholesterol disorder, according to a long-term European study. Researchers looked at 194 children and teens in the Netherlands with familial hypercholesterolemia, which puts people at risk for premature hardening of the arteries (atherosclerosis). The inherited disorder affects about one in 500 people. The youngsters were prescribed the statin drug pravastatin and followed for 10 years. The results showed that taking the drug prevented premature atherosclerosis, according to the research, which was done by Dr. D. Meeike Kusters, of the Academic Medical Center in Amsterdam, and colleagues. The younger the age of those who start taking the drug, the better, noted the study, published in the Sept. 10 issue of the Journal of the American Medical ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Pravastatin, Atorvastatin, Zocor, Lovastatin, Rosuvastatin, Red Yeast Rice, Livalo, Pravachol, Atherosclerosis, Lescol, Lescol XL, Mevacor, Pitavastatin, Altoprev, Fluvastatin, Baycol

Cholesterol Drugs' Benefits Far Outweigh Side Effects, Review Finds

Posted 6 Aug 2014 by Drugs.com

TUESDAY, Aug. 5, 2014 – The benefits of long-term use of cholesterol-lowering statin drugs greatly outweigh the risks, according to a review of research published over 20 years. Some experts fear that statins may be overused, but these new findings could offer reassurance to the more than 200 million people worldwide who take the drugs, the review authors said. Common statin medications include Crestor, Lipitor and Zocor. "For most at-risk patients, the cardiovascular benefits far exceed the risks," study author Dr. Chintan Desai, a clinical cardiology fellow at the Johns Hopkins Hospital, said in a Hopkins news release. They analyzed data from studies conducted since 1994 that included more than 150,000 middle-aged and elderly men and women who took statins and were followed for about five years. The results showed that long-term statin use slightly increased the risk of some side ... Read more

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Cholesterol Levels May Be Linked to Breast Cancer Risk

Posted 7 Jul 2014 by Drugs.com

FRIDAY, July 4, 2014 – High cholesterol levels may increase a woman's risk of developing breast cancer, a large new British study reports. The findings suggest that keeping tight control over cholesterol through medication could help prevent breast cancer, said lead author Rahul Potluri, a researcher at the Aston University School of Medical Sciences in Birmingham, England. "This is a preliminary study and further research is required before anything can be confirmed," Potluri said. "However, 10 to 15 years down the line, if further prospective studies confirm these findings, there is the possibility for a clinical trial of the use of statins in breast cancer." Statins are prescription drugs used to treat high cholesterol. Researchers reviewed the medical records of over 660,000 female patients in Birmingham and Manchester between 2000 and 2013, using a statistical model to study the ... Read more

Related support groups: Breast Cancer, High Cholesterol

FDA Medwatch Alert: Red Yeast Rice by Doctor’s Best: Recall - Undeclared Lovastatin

Posted 24 Jun 2014 by Drugs.com

ISSUE: Doctor’s Best is voluntarily recalling lot 3121005 (7379 bottles) of Red Yeast Rice dietary supplement, 600 mg Capsules, 120-count bottles to the retail level. Doctor’s Best Red Yeast Rice has been found to contain undeclared lovastatin, a previously approved drug indicated for the treatment of high cholesterol, making this an unapproved new drug. Consumers who use supplements found to contain lovastatin in rare cases could result in serious muscle injury; particularly if taking with prescription “statins” such as lovastatin, simvastatin, or atorvastatin. Pregnant women could theoretically put their unborn child at risk by using this product with undeclared lovastatin. Patients with pre-existing liver disease may be at an increase risk for liver injury following chronic use of statins. BACKGROUND:  Doctor’s Best Red Yeast Rice was distributed nationwide through retail and internet ... Read more

Related support groups: High Cholesterol, Lipitor, Simvastatin, Crestor, Pravastatin, Atorvastatin, Zocor, Lovastatin, Rosuvastatin, Red Yeast Rice, Livalo, Pravachol, Lescol, Lescol XL, Mevacor, Fluvastatin, Altoprev, Pitavastatin, Baycol, Cerivastatin

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