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Related terms: Hepatitis C, Chronic, Chronic Hepatitis C, Hep C

Liver Damage From Hepatitis C More Widespread Than Thought

Posted 2 days 18 hours ago by Drugs.com

THURSDAY, Aug. 27, 2015 – Severe liver damage may be four times more common among Americans with the liver infection hepatitis C than previously believed, a new study suggests. Analyzing nearly 9,800 patients with hepatitis C, researchers learned that using a biopsy alone to reveal liver cirrhosis – indicating scarring in the organ – is likely to seriously underestimate its prevalence. The recent emergence of medications that can cure hepatitis C, a "silent killer" that often goes undetected until advanced disease sets in years later, adds weight to the new findings, doctors said. "We thought it would be important to provide the health care community with some estimate as to the severity of liver disease among patients with hepatitis C because it's a question that comes up very frequently: Just how sick is this community?" said study author Dr. Stuart Gordon, director of hepatology ... Read more

Related support groups: Hepatitis C, Harvoni, Cirrhosis, Liver Cirrhosis, Biliary Cirrhosis

More Hepatitis C Cases Being Seen in Urban ERs

Posted 7 Aug 2015 by Drugs.com

FRIDAY, Aug. 7, 2015 – New research reveals high rates of hepatitis C infection among intravenous drug users and baby boomers seen in urban emergency departments. And three-quarters of those who tested positive for the potentially deadly virus did not know they were infected, the researchers added. "Given skyrocketing rates of injection heroin use around the country, we expect the already high rates of hepatitis C infection to explode," said study author Dr. Douglas White, from Highland Hospital in Oakland, Calif. Hepatitis C is the most common chronic bloodborne infection in the United States, and it is a leading cause of liver failure, liver cancer and liver transplants. Researchers said the disease was found in 10 percent of the emergency department patients who were tested, and 70 percent of them had chronic infections. Only 24 percent of the patients who tested positive for ... Read more

Related support groups: Hepatitis C, Heroin

FDA Approves Daklinza (daclatasvir) for Chronic Hepatitis C Genotype 3 Infections

Posted 27 Jul 2015 by Drugs.com

July 24, 2015 – The U.S. Food and Drug Administration today approved Daklinza (daclatasvir) for use with sofosbuvir to treat hepatitis C virus (HCV) genotype 3 infections. Daklinza is the first drug that has demonstrated safety and efficacy to treat genotype 3 HCV infections without the need for co-administration of interferon or ribavirin, two FDA-approved drugs also used to treat HCV infection. Hepatitis C is a viral disease that causes inflammation of the liver that can lead to diminished liver function or liver failure. Most people infected with HCV have no symptoms of the disease until liver damage becomes apparent, which may take several years. Some people with chronic HCV infection develop scarring and poor liver function (cirrhosis) over many years, which can lead to complications such as bleeding, jaundice (yellowish eyes or skin), fluid accumulation in the abdomen, ... Read more

Related support groups: Hepatitis C, Sofosbuvir, Daklinza, Daclatasvir

FDA Approves Technivie (ombitasvir, paritaprevir and ritonavir) for Chronic Hepatitis C Genotype 4 Infections

Posted 26 Jul 2015 by Drugs.com

July 24, 2015 – The U.S. Food and Drug Administration today approved Technivie (ombitasvir, paritaprevir and ritonavir) for use in combination with ribavirin for the treatment of hepatitis C virus (HCV) genotype 4 infections in patients without scarring and poor liver function (cirrhosis). Technivie in combination with ribavirin is the first drug that has demonstrated safety and efficacy to treat genotype 4 HCV infections without the need for co-administration of interferon, an FDA-approved drug also used to treat HCV infection. “Today’s approval provides the first treatment option for patients with genotype 4 HCV infections without requiring use of interferon,” said Edward Cox, M.D., director of the Office of Antimicrobial Products in the FDA’s Center for Drug Evaluation and Research. Hepatitis C is a viral disease that causes inflammation of the liver that can lead to diminished li ... Read more

Related support groups: Hepatitis C, Ombitasvir/paritaprevir/ritonavir, Technivie

Technivie Approved for Hepatitis C

Posted 26 Jul 2015 by Drugs.com

FRIDAY, July 24, 2015 – Technivie (ombitasvir, paritaprevir and ritonavir) has been approved by the U.S. Food and Drug Administration, in tandem with ribavirin, to treat hepatitis C genotype 4 infection among people without poor liver function (cirrhosis) and without scarring. Some 2.7 million Americans have hepatitis C, and genotype 4 is among the least common genetic subtypes, the agency said. Technivie is the first drug to be sanctioned to treat genotype 4 hepatitis C infection without requiring co-use of the drug interferon, the agency said Friday in a news release. Infection with the hepatitis C virus causes liver inflammation that may lead to cirrhosis or liver failure. Most infected people don't develop symptoms until liver damage has already occurred, the FDA said. Symptoms of cirrhosis may include a yellowing of the eyes and skin called jaundice, abdominal fluid retention and ... Read more

Related support groups: Hepatitis C, Ombitasvir/paritaprevir/ritonavir, Technivie

Most U.S. Hepatitis C Infections May Be Missed: Study

Posted 30 Jun 2015 by Drugs.com

TUESDAY, June 30, 2015 – New cases of hepatitis C are drastically underreported to federal officials, researchers contend in a new study. And they suggested that may be hampering public health efforts to cope with the chronic infection that can lead to cirrhosis or liver cancer. The new study found that only one out of 183 Massachusetts residents diagnosed between 2001 and 2011 with acute hepatitis C infection was reported to the U.S. Centers for Disease Control and Prevention. The rest went unreported, either because their test results didn't come back quickly enough or because the results didn't meet the strict CDC definition for hepatitis C infection, said senior study author Dr. Arthur Kim, director of the Viral Hepatitis Clinic at Massachusetts General Hospital in Boston. "We were shocked to find only one made it to the CDC, reported as an acute hepatitis C case," Kim said. "This ... Read more

Related support groups: Cancer, Hepatitis C

Experimental Drug Combo Shows Promise Against Hepatitis C

Posted 5 May 2015 by Drugs.com

TUESDAY, May 5, 2015 – Researchers have released yet another study finding impressive results for an experimental drug combo that aims to rid the body of infection with liver-damaging hepatitis C. In this case, a combination of three drugs in the pipeline – daclatasvir, asunaprevir and beclabuvir – effectively cleared the virus in 93 percent of patients, according to new research from Duke University in Durham, N.C. All of the patients had already developed an infection-linked scarring of the liver known as cirrhosis. None of these drugs has been approved by the U.S. Food and Drug Administration, but daclatasvir is currently under FDA review, according to a Duke news release. One U.S. expert said the drug combination could be an additional advance against hepatitis C. "This regimen is yet another all-oral treatment for the most common type of hepatitis C, which offers high cure rates ... Read more

Related support groups: Hepatitis C, Harvoni, Sovaldi, Sofosbuvir

Drug-Related HIV Outbreak Spurs Nationwide Alert

Posted 24 Apr 2015 by Drugs.com

FRIDAY, April 24, 2014 – With narcotic painkiller abuse now linked to 142 cases of HIV in rural Indiana, U.S. health officials are alerting other states to watch for clusters of HIV and hepatitis C among injection drug users. The Scott County epidemic is "a powerful reminder that people who inject drugs are at high risk for both HIV and hepatitis," said Dr. Jonathan Mermin, director of the National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention. HIV, the AIDS-causing virus, "can gain ground at any time unless we remain vigilant about prevention, testing and care," he said during a Friday morning news conference. There is no indication that HIV infection among injection drug users is spreading beyond this area of Indiana, he said. "But it will be critical to examine all available data on the state and local level to assess whether HIV is increasing among injection drug ... Read more

Related support groups: Hepatitis C, HIV Infection, Toxic Reactions Incl Drug and Substance Abuse

New Specialty Medicines Drive Up Drug Spending

Posted 14 Apr 2015 by Drugs.com

TUESDAY, April 14, 2015 (HealthDay New) – New medicines targeting conditions like hepatitis C, cancer and multiple sclerosis helped to propel drug spending to its highest level in more than a decade, a new report finds. Medicine sales jumped 13 percent, to nearly $374 billion, in 2014 after a period of mostly low single-digit growth, according to the report released Tuesday by the IMS Institute for Healthcare Informatics in Parsippany, N.J. Last year's increase was the largest since 2001, as spending rose 17 percent to nearly $174 billion on the growth of new "blockbuster" drugs, the report said. For the report, the IMS Institute tallies U.S. drug spending across all settings – from hospitals to retail pharmacies – and outlines the forces channeling that growth. The institute received no drug company or government funding for the report. New drug innovation, higher sticker prices and ... Read more

Related support groups: Cancer, Multiple Sclerosis, Hepatitis C

Cheap Allergy Drug May Hold Potential as Hepatitis C Treatment

Posted 8 Apr 2015 by Drugs.com

WEDNESDAY, April 8, 2015 – Preliminary lab research suggests a hay fever drug that costs about 50 cents a pill has the potential to treat hepatitis C, a stubborn disease that has spawned drugs that sell for $1,000 a dose. It's too early to know if the antihistamine chlorcyclizine HCI will work in people as a treatment for hepatitis C. Still, the new research suggests that "the drug blocks the virus getting into cells and is different from the current hepatitis C drugs, which block viral replication," said study co-author Dr. T. Jake Liang, a senior investigator with the U.S. National Institute of Diabetes and Digestive and Kidney Diseases. Moreover, "this drug complements the existing hepatitis C drugs and can be used in combination with them," Liang added. Hepatitis C often leads to serious liver complications such as cirrhosis. Some expensive new medications are "astonishingly ... Read more

Related support groups: Hepatitis C, Poly-Tussin, Dallergy, Chlorcyclizine, Notuss-NX, Chlorcyclizine/Hydrocortisone, Chlorcyclizine/phenylephrine, Chlorcyclizine/codeine, Chlophedianol/chlorcyclizine/pseudoephedrine, Biclora, Nasotuss, Biclora-D, Notuss-NXD, Mantadil, Chlorcyclizine/pseudoephedrine, Chlorcyclizine/codeine/pseudoephedrine, Chlophedianol/chlorcyclizine, Ahist, Chlorcyclizine/codeine/phenylephrine, NasOpen

FDA Warns of Cardiac Effect When Heart Drug Mixed With Hepatitis C Meds

Posted 25 Mar 2015 by Drugs.com

WEDNESDAY, March 25, 2015 – A potentially life-threatening slowing of the heart can occur when the common heart drug amiodarone is taken with new hepatitis C medications, the U.S. Food and Drug Administration warns. The dangerous slowing of the heart – called symptomatic bradycardia – can occur when amiodarone is taken with the hepatitis C drugs Harvoni (ledipasvir/sofosbuvir) or Sovaldi (sofosbuvir) and combined with another direct-acting antiviral for the treatment of hepatitis C. Harvoni and Sovaldi are two new medicines recently approved by the FDA to help rid the body of hepatitis C infection. If left untreated, hepatitis C infection can damage the liver and raise the odds of liver failure and liver cancer. Amiodarone is commonly used to treat heartbeat irregularities, the FDA noted in a news release. Information about the risk of the drugs used in combination is being added to ... Read more

Related support groups: Hepatitis C, Harvoni, Amiodarone, Sovaldi, Bradyarrhythmia, Cordarone, Sofosbuvir, Pacerone, Nexterone, Cordarone IV

FDA Medwatch Alert: Hepatitis C Treatments Containing Sofosbuvir in Combination With Another Direct Acting Antiviral Drug: Drug Safety Communication - Serious Slowing of Heart Rate When Used With Antiarrhythmic Drug Amiodarone

Posted 24 Mar 2015 by Drugs.com

[Posted 03/24/2015] ISSUE: FDA is warning that serious slowing of the heart rate can occur when the antiarrhythmic drug amiodarone is taken together with either the hepatitis C drug Harvoni (ledipasvir/sofosbuvir) or with Sovaldi (sofosbuvir) taken in combination with another direct acting antiviral for the treatment of hepatitis C infection. FDA is adding information about serious slowing of the heart rate, known as symptomatic bradycardia, to the Harvoni and Sovaldi labels. FDA is recommending that health care professionals should not prescribe either Harvoni or Sovaldi combined with another direct acting antiviral, such as the investigational drug daclatasvir or Olysio (simeprevir), with amiodarone. FDA review of submitted postmarketing adverse event reports found that patients can develop a serious and life-threatening symptomatic bradycardia when either Harvoni or Sovaldi ... Read more

Related support groups: Hepatitis C, Harvoni, Amiodarone, Sovaldi, Cordarone, Sofosbuvir, Pacerone, Olysio, Ledipasvir/sofosbuvir, Simeprevir, Cordarone IV, Nexterone

Hepatitis C Drugs Will 'Strain Budgets' at Current Prices: Study

Posted 16 Mar 2015 by Drugs.com

MONDAY, March 16, 2015 – New hepatitis C drugs promise cure rates above 90 percent, but could prove to be budget-busters for public and private health insurers, a new analysis finds. Recently approved drugs for chronic hepatitis C have been heralded as a breakthrough that could make the liver disease "rare" in the United States. But with prices topping $1,000 per pill, government and private insurers are balking – often putting limits on which patients qualify for coverage. Now two new studies in the March 16 Annals of Internal Medicine conclude that for individual patients, treatment with the pricey pills is "cost-effective." That's a calculation that takes into account the years of better health and quality of life people will likely enjoy. The bad news? One study estimates that state governments and insurers will have to dig up an extra $65 billion over five years to get the drugs ... Read more

Related support groups: Hepatitis C, Harvoni, Sovaldi, Sofosbuvir, Chronic Active Hepatitis, Infectious Hepatitis

Hepatitis C Infections in Hospitals Show Need for Tight Infection Control Practices

Posted 27 Feb 2015 by Drugs.com

FRIDAY, Feb. 27, 2015 – Two cases of hepatitis C infection that occurred during routine surgeries highlight the need for hospitals to tighten infection control to prevent more transmissions, officials said Friday. In one case, two New Jersey patients (one of them had hepatitis C) received an injection of the anesthetic propofol from the same medication cart. In the other instance, two Wisconsin patients (one of them had hepatitis C) received kidneys that had been prepared for transplantation on the same machine, according to an article in the Feb. 27 issue of Morbidity and Mortality Weekly Report, a publication of the U.S. Centers for Disease Control and Prevention. The source of the infection in the Wisconsin case was not pinpointed, said Gwen Borlaug, coordinator of the HAI Prevention Program at the Wisconsin Division of Public Health, but "we identified breaches in infection control ... Read more

Related support groups: Hepatitis C

Many With Hepatitis C Missing Out on Treatment, Study Finds

Posted 11 Jan 2015 by Drugs.com

SUNDAY, Jan. 11, 2015 – Many hepatitis C patients get "lost" in the U.S. health care system, a new study suggests. Researchers looked at data from about 13,600 people in Philadelphia who tested positive for hepatitis C virus between January 2010 and December 2013. During that time, just 27 percent of the patients were in care and 15 percent had been treated or were receiving treatment, the study authors found. The study was recently published in the journal Hepatology. "Our findings show that many [hepatitis C] patients are lost at each stage of the health care continuum from screening to disease confirmation to care and treatment," Kendra Viner, of the Philadelphia Department of Public Health, said in a journal news release. "The fact that so few patients with [hepatitis C virus] are making it to treatment underscores the need to build awareness among at-risk groups of the importance ... Read more

Related support groups: Hepatitis C

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Harvoni, Sovaldi, ribavirin, Incivek, Pegasys, Victrelis, PegIntron, interferon alfa-2b, Ribasphere, view more... Copegus, sofosbuvir, telaprevir, boceprevir, Rebetol, Olysio, peginterferon alfa-2b, Daklinza, peginterferon alfa-2a, Intron A, ledipasvir / sofosbuvir, RibaPak, dasabuvir / ombitasvir / paritaprevir / ritonavir, simeprevir, Viekira Pak, Technivie, ombitasvir / paritaprevir / ritonavir, Infergen, RibaTab, daclatasvir, interferon alfacon-1