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FDA Medwatch Alert: Diflucan (fluconazole): Drug Safety Communication - Long-term, High-dose Use During Pregnancy May Be Associated With Birth Defects

Posted 3 Aug 2011 by Drugs.com

ISSUE: FDA is informing the public that treatment with chronic, high doses (400-800mg/day) of Diflucan (fluconazole) during the first trimester of pregnancy may be associated with a rare and distinct set of birth defects in infants. This risk does not appear to be associated with a single, low dose of fluconazole 150mg to treat vaginal yeast infection (candidiasis). Based on this information, the pregnancy category for fluconazole indications (other than vaginal candidiasis) has been changed from category C to category D. The pregnancy category for a single, low dose of fluconazole has not changed and remains category C. BACKGROUND: Diflucan is used to treat yeast infections of the vagina, mouth, throat, esophagus and other organs. It is also used to prevent yeast infections in patients who are likely to become infected because they are being treated with chemotherapy or radiation ... Read more

Related support groups: Fluconazole, Diflucan

High Dose of Yeast Infection Drug Linked to Birth Defects, FDA Says

Posted 3 Aug 2011 by Drugs.com

WEDNESDAY, Aug. 3 – Pregnant women who take ongoing, high doses of the drug fluconazole (brand name Diflucan) may be at increased risk of having babies with birth defects, the U.S. Food and Drug Administration warned Wednesday. The drug is used to treat yeast infections of the vagina, mouth, throat, esophagus and other organs. It's also used to treat meningitis caused by a certain type of fungus and to prevent yeast infections in patients undergoing chemotherapy or radiation therapy prior to a bone marrow transplant. The FDA said chronic, high doses (400 to 800 milligrams per day) of fluconazole during the first trimester of pregnancy may increase the risk of a rare and distinct set of birth defects. There doesn't appear to be any increased risk with a single, low dose (150 mg) to treat vaginal yeast infection. Based on the available information, the FDA has changed the pregnancy ... Read more

Related support groups: Fluconazole, Diflucan

Smarten Up About Antibiotics, CDC Urges

Posted 18 Nov 2010 by Drugs.com

THURSDAY, Nov. 18 – Knowing when to take antibiotics – and when not to – can help fight the rise of deadly "superbugs," say experts at the U.S. Centers for Disease Control and Prevention. About half of antibiotics prescribed are unnecessary or inappropriate, the agency says, and overuse has helped create bacteria that don't respond, or respond less effectively, to the drugs used to fight them. "Antibiotics are a shared resource that has become a scarce resource," said Dr. Lauri Hicks, a medical epidemiologist at the CDC. She's also medical director a of new program, Get Smart: Know When Antibiotics Work, that had its launch this week. "Everyone has a role to play in preventing the spread of antibiotic resistance," Hicks said. The stakes are high, said Dr. Arjun Srinivasan, CDC's associate director for health care-associated infection prevention programs. Almost every type of bacteria ... Read more

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Related Condition Support Groups

Vaginal Yeast Infection, Oral Thrush, Candida Infections, Systemic, Candida Urinary Tract Infection, Onychomycosis -- Toenail, Tinea Versicolor, Esophageal Candidiasis, Fungal Infection -- Internal and Disseminated, Fungal Infection Prophylaxis, view more... Bone Marrow Transplantation, Fungal Pneumonia, Chronic Mucocutaneous Candidiasis, Coccidioidomycosis, Histoplasmosis, Onychomycosis -- Fingernail, Cryptococcal Meningitis -- Immunocompetent Host, Blastomycosis, Coccidioidomycosis -- Meningitis, Cryptococcal Meningitis -- Immunosuppressed Host, Fungal Peritonitis, Cryptococcosis