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Crohn's Disease Blog

Gut Bacteria May Play Role in Crohn's Disease

Posted 12 Mar 2014 by Drugs.com

WEDNESDAY, March 12, 2014 – The community of bacteria that typically live in the human gut is radically altered in patients with Crohn's disease, a new study shows. Overall, patients with Crohn's have less diversity among their intestinal bacteria than healthy individuals. And certain types of harmful bacteria appear to be increased in Crohn's patients, while the amounts of beneficial bacteria are decreased, the study found. Whether those changes are a cause or a consequence of the disease isn't known. But the discovery may help doctors diagnose patients more quickly and it may point the way to new treatments for the disease, which is estimated to affect about 700,000 people in the United States. For the study, researchers recruited nearly 500 patients who were newly diagnosed with Crohn's disease and more than 200 who were having intestinal problems without inflammation. Crohn's ... Read more

Related support groups: Crohn's Disease

Thalidomide May Help Kids With Crohn's Disease

Posted 26 Nov 2013 by Drugs.com

TUESDAY, Nov. 26, 2013 – Thalidomide, a drug made infamous after it caused devastating birth defects in the 1950s, may help treat children with Crohn's disease who haven't responded to other medications, new research suggests. After eight weeks of treatment, more than 46 percent of children taking thalidomide had reached remission, compared to about 11 percent of those given an inactive placebo. And remission lasted longer for the children on thalidomide – an average of 181 weeks compared to just 6.3 weeks for those who took the placebo. The Italian researchers published their results in the Nov. 27 issue of the Journal of the American Medical Association. Funding for the study was provided by the Italian Medicines Agency, while the drug's manufacturer, Celgene, provided the drug for the study. Crohn's disease is an inflammatory bowel disease. It's estimated that about 500,000 people ... Read more

Related support groups: Crohn's Disease, Thalidomide, Thalomid

Crohn's and Colitis May Be Tied to Risk of Heart Attack, Stroke

Posted 14 Oct 2013 by Drugs.com

MONDAY, Oct. 14 – People with inflammatory bowel disease may be at increased risk for heart attack and stroke, a new study suggests. Researchers analyzed data from more than 150,000 inflammatory bowel disease (IBD) patients who took part in nine studies. They found that these patients had a 10 percent to 25 percent increased risk of stroke and heart attack, and that this increased risk was more prevalent among women. Doctors need to be aware of this link and should focus on controlling other stroke and heart attack risk factors, such as smoking, high blood pressure and diabetes, study author Siddharth Singh, of the Mayo Clinic in Rochester, Minn., said in a news release from the clinic. The study was scheduled for presentation Monday at the annual meeting of the American College of Gastroenterology, in San Diego. Research presented at medical meetings should be viewed as preliminary ... Read more

Related support groups: Heart Attack, Crohn's Disease, Colitis, Myocardial Infarction

Drug Shows Promise for People With Colitis, Crohn's Disease

Posted 21 Aug 2013 by Drugs.com

WEDNESDAY, Aug. 21 – An experimental drug may help some people who have inflammatory bowel disease that has failed to respond to current medications, two new clinical trials find. The drug, called vedolizumab, is being developed to treat the two main forms of inflammatory bowel disease (IBD) – ulcerative colitis and Crohn's disease. Both arise when the immune system launches an abnormal attack on the lining of the digestive tract, leading to chronic inflammation and symptoms such as abdominal cramps, diarrhea and rectal bleeding. In the new trials, reported in the Aug. 22 issue of the New England Journal of Medicine, researchers found that vedolizumab worked in some cases where standard IBD medications had failed. The drug was more effective for colitis than for Crohn's, however, and an expert not involved in the studies said he suspects vedolizumab might be approved for colitis ... Read more

Related support groups: Crohn's Disease, Ulcerative Colitis, Inflammatory Bowel Disease

Extra Vitamin D May Ease Crohn's Symptoms, Study Finds

Posted 19 May 2013 by Drugs.com

SATURDAY, May 18 – Vitamin D supplements may help those with Crohn's disease overcome the fatigue and decreased muscle strength associated with the inflammatory bowel disease, according to new research. Extra vitamin D "was associated with significantly less physical, emotional and general fatigue, greater quality of life and the ability to perform activities of daily living," said Tara Raftery, a research dietitian and doctoral candidate at Trinity College Dublin. She is scheduled to present the findings Saturday at the Digestive Disease Week meeting in Orlando, Fla. Raftery and her colleagues evaluated 27 patients who had Crohn's in remission. (Even in remission, fatigue and quality of life can be problematic.) The patients were assigned to take either 2,000 IUs (international units) of vitamin D a day or a dummy vitamin for three months. Before and after the study, the researchers ... Read more

Related support groups: Vitamin D, Crohn's Disease, Vitamin D3, Cholecalciferol, Ergocalciferol, Drisdol, Hectorol, Replesta, Doxercalciferol, Delta D3, Calciferol, D3-5, D400, D2000, D 1000 IU, D3-50, Calcidol

Flu Vaccine Safe for Kids With Crohn's, Colitis: Study

Posted 6 May 2013 by Drugs.com

MONDAY, May 6 – Yearly flu vaccinations are safe for children with inflammatory bowel disease, but too few of these youngsters get a flu shot because their parents worry about possible side effects, researchers report. Not only does vaccination help protect against the flu, it may even reduce inflammatory bowel disease (IBD) symptoms, according to the study, which was published May 6 in the journal Pediatrics. Children with inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis, often experience chronic abdominal pain, diarrhea, joint pain and other symptoms. The researchers looked at all children under age 19 diagnosed with IBD in Ontario, Canada, between 1999 and 2009. They found that about 25 percent of the IBD patients received a flu shot from a doctor or nurse practitioner and that these youngsters had no increase in IBD-related health issues after being ... Read more

Related support groups: Crohn's Disease, Colitis, FluLaval, Afluria, Fluzone, Flushield, Influenza Virus Vaccine, Inactivated, Flucelvax, Fluarix, Fluvirin, Fluzone SV, Fluzone Preservative-Free, Fluzone WV, Fluogen, Agriflu, Fluzone PFS

Study Finds No Tie Between Acne Drug Accutane and Crohn's, Colitis

Posted 20 Feb 2013 by Drugs.com

WEDNESDAY, Feb. 20 – A new study counters the notion that the prescription acne drug Accutane raises the risk of Crohn's disease or colitis in women. The study of more than 45,000 women found no such link between Accutane (isotretinoin) use and these illnesses, which are collectively known as inflammatory bowel disease (IBD). One expert not connected to the study called it a "welcome review." "There has been a lot of speculation and even litigation that Accutane causes inflammatory bowel disease," said Dr. Michele Green, a dermatologist at Lenox Hill Hospital in New York City. "Dermatologists have been discouraged from using Accutane and the makers of Accutane have discontinued their production due to countless lawsuits," she noted, but "this study once again highlights the safety of Accutane." Ulcerative colitis and Crohn's disease are the most common forms of IBD, a group of ... Read more

Related support groups: Acne, Accutane, Crohn's Disease, Colitis, Claravis, Isotretinoin, Inflammatory Bowel Disease, Amnesteem, Sotret, Myorisan, Absorica

Scientists Now See 200 Genes Linked to Crohn's Disease

Posted 19 Dec 2012 by Drugs.com

WEDNESDAY, Dec. 19 – Using a new technique, researchers have pinpointed a large number of additional genes associated with Crohn's disease, bringing the total to 200. The scientists at University College London, in England, created a new method to identify and map the locations of genes associated with complex inherited diseases such as Crohn's. Crohn's disease, a type of inflammatory bowel disease, affects about 100 to 150 people out of every 100,000. Understanding more about the genes associated with the disease may lead to improved treatments, the researchers said. The 200 genes so far linked to Crohn's are more than have been found for any other disease, according to the researchers. For example, just 66 gene regions are known for type 2 diabetes. "The discovery of so many gene locations for Crohn's disease is an important step forward in understanding the disease, which has a very ... Read more

Related support groups: Crohn's Disease, Crohn's Disease - Maintenance, Crohn's Disease - Acute

Crohn's Disease in Children May Start From Bacteria

Posted 31 Oct 2012 by Drugs.com

WEDNESDAY, Oct. 31 – Certain types of bacteria may cause and maintain Crohn's disease, according to a new study. Crohn's causes inflammation of the digestive system. Symptoms include abdominal pain, diarrhea, weight loss, joint pain, skin problems, fever and bleeding from the rectum. In this study, researchers found that 19 children newly diagnosed with Crohn's disease had different levels of a group of bacteria called proteobacteria, which include E. coli and Campylobacter concisus. The researchers also checked bacteria levels in 21 healthy children. Patients with mild Crohn's had higher levels of proteobacteria in their intestinal tracts than those with moderate to severe disease and children without Crohn's disease. This suggests that these types of bacteria may play a role in causing the disease, said study principal investigator Hazel Mitchell of the University of New South Wales, ... Read more

Related support groups: Crohn's Disease

Gene Study Yields New Clues to Crohn's Disease, Colitis

Posted 31 Oct 2012 by Drugs.com

WEDNESDAY, Oct. 31 – Scientists say research into the genetics of inflammatory bowel disease – which includes Crohn's disease and ulcerative colitis – is revealing new insights into the origin of this set of illnesses. The researchers said they have linked genetic variations in 163 regions of the human genome with a heightened risk of developing inflammatory bowel disease (IBD). Of those regions, 71 are newly discovered. IBD comprises a group of chronic, autoimmune digestive disorders that affect 2.5 million people worldwide. Symptoms include abdominal pain and diarrhea and patients typically require lifelong treatment with drug therapy. Many also require surgery to repair tissue damage caused by the disease. In this study, researchers analyzed data from about 34,000 people who took part in 15 previous studies of either Crohn's disease or ulcerative colitis. They also examined data ... Read more

Related support groups: Crohn's Disease, Colitis, Inflammatory Bowel Disease

Psoriasis Drug May Help People With Crohn's Disease: Study

Posted 17 Oct 2012 by Drugs.com

WEDNESDAY, Oct. 17 – The drug Stelara, used to treat the skin condition psoriasis, may also be effective against Crohn's disease, according to a new study. Researchers from the University of California, San Diego School of Medicine found Stelara (ustekinumab) blocks two proteins known to cause inflammation. Crohn's disease patients with moderate-to-severe cases of the debilitating inflammatory bowel disease experienced improvements after six weeks of treatment, the team noted. One specialist not connected to the study welcomed the results. "This study confirms an earlier study showing that ustekinumab can be an effective therapy," said Dr. Bruce Sands, professor of medicine at the Mount Sinai School of Medicine in New York City. "Given the large unmet need for these individuals with refractory [hard-to-treat] Crohn's disease, these results are a great step forward," he said. Roughly ... Read more

Related support groups: Psoriasis, Crohn's Disease, Stelara, Ustekinumab

Antibiotics in Childhood May Increase Bowel Disease Risk: Study

Posted 24 Sep 2012 by Drugs.com

MONDAY, Sept. 24 – Use of certain antibiotics may put children at higher risk for developing bowel diseases, new research has found. The earlier children take antibiotics and the more they take, the higher the risk of later developing the inflammatory bowel diseases known as Crohn's disease and ulcerative colitis, the researchers found. "There appears to be a 'dose response' effect," said Dr. Matt Kronman, assistant professor of pediatric infectious diseases at the University of Washington School of Medicine in Seattle. "The more antibiotics children took, the more their risk increased." Earlier studies had suggested a link between bowel disease and antibiotics use, but most of those studies had limitations. The new study, published online Sept. 24 in the journal Pediatrics, looked at data on more than 1 million children 17 years old or younger in nearly 500 health practices ... Read more

Related support groups: Amoxicillin, Penicillin, Metronidazole, Flagyl, Crohn's Disease, Colitis, Ulcerative Colitis, Tetracycline, Amoxil, Inflammatory Bowel Disease, Penicillin VK, Flagyl IV, Metro, Flagyl IV RTU, Amoxil Pediatric Drops, Bicillin LA, Trimox, Penicillin G Procaine, Flagyl ER, Bicillin L-A

Health Tip: Crohn's Disease Can Cause Complications

Posted 23 Aug 2012 by Drugs.com

-- Crohn's disease causes portions of the digestive tract to swell. This can trigger pain and cause the intestines to empty frequently. Swelling and scar tissue can trigger dangerous complications, including a blockage in the intestines, the U.S. National Digestive Diseases Information Clearinghouse says. The agency says additional complications of Crohn's could include: Ulcers called fistulas that form in the intestinal tract and may tunnel to surrounding tissue. Malnutrition or vitamin deficiencies. Anemia. Slowed growth in children. Bone problems, including osteoporosis. Read more

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Humira Might Help Kids With Tough-to-Treat Crohn's Disease

Posted 9 Aug 2012 by Drugs.com

THURSDAY, Aug. 9 – The "biologic" drug Humira could be an effective therapy for children with tough-to-treat Crohn's disease, a new study finds. Crohn's disease is an inflammation of the digestive tract that can lead to swelling, pain and ulcers. Although the disease can affect any part of the digestive tract, the most common spot is the small intestine. The new study revealed that treatment with Humira (adalimumab), could help children with Crohn's stay in remission without stunting their growth or delaying puberty, as can happen with other drugs currently used to treat the disease. One expert not connected to the study welcomed the findings. "This drug helps expand the available treatments to control inflammation in Crohn's disease," said Dr. Joseph Levy, a pediatric gastroenterologist at NYU Langone Medical Center, in New York City. "This is a welcome addition and it will improve ... Read more

Related support groups: Humira, Crohn's Disease, Adalimumab

Mouse Study Suggests Certain Fats Could Trigger Crohn's, Colitis

Posted 13 Jun 2012 by Drugs.com

WEDNESDAY, June 13 – Certain types of saturated fats common in today's Western diet may change gut bacteria and trigger inflammatory bowel disease in people genetically predisposed to the disorder, according to a new study that looked at this relationship in mice. Inflammatory bowel disease includes ulcerative colitis and Crohn's disease. The University of Chicago researchers said their findings help explain why once rare immune-system-related disorders such as inflammatory bowel disease have become more common in the United States and other Westernized nations in the last half-century. The researchers said their study may shed some light on why many people who are genetically prone to the condition still don't develop it and how certain environmental factors can cause inflammation in those at risk. Scientists note, however, that research with animals often fails to provide similar ... Read more

Related support groups: Crohn's Disease, Colitis, Ulcerative Colitis, Crohn's Disease - Maintenance, Crohn's Disease - Acute, Ulcerative Colitis - Active, Ulcerative Colitis - Maintenance

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