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Scientists Grow, Implant Human Intestinal Tissue in Mice

Posted 11 days ago by Drugs.com

SUNDAY, Oct. 19, 2014 – New stem cell-based research could improve understanding of intestinal diseases and eventually lead to new treatments, a new study suggests. Scientists used stem cells to grow "organoids" of functioning human intestinal tissue in a lab dish. They then transplanted the organoids into mice, creating a new model for studying intestinal disorders, according to the researchers. "This provides a new way to study the many diseases and conditions that can cause intestinal failure, from genetic disorders appearing at birth to conditions that strike later in life, such as cancer and Crohn's disease," lead investigator Dr. Michael Helmrath, surgical director of the Intestinal Rehabilitation Program at the Cincinnati Children's Hospital Medical Center, said in a center news release. "These studies also advance the longer-term goal of growing tissues that can replace damaged ... Read more

Related support groups: Crohn's Disease, Crohn's Disease - Maintenance, Crohn's Disease - Acute

Certain Autoimmune Drugs in Pregnancy May Up Newborn Infection Risk: Study

Posted 3 Oct 2014 by Drugs.com

FRIDAY, Oct. 3, 2014 – When given to pregnant women, a common treatment for ulcerative colitis may inadvertently lower their baby's ability to fight off infections at birth, new French research suggests. The treatment, called anti-TNF therapy, is an injected, artificial antibody. This type of medication is widely seen as a safe and effective way to tackle a wide range of autoimmune disorders, such as rheumatoid arthritis and inflammatory bowel conditions that include ulcerative colitis and Crohn's disease. It's not unusual for pregnant women to receive the treatment, given that inflammatory bowel diseases often strike women of childbearing age. However, this type of drug can cross the placenta and reach the fetus, the study authors said. And four French cases – all involving babies born to women exposed to Remicade (infliximab) during pregnancy – suggest the therapy may cause newborn ... Read more

Related support groups: Rheumatoid Arthritis, Humira, Enbrel, Crohn's Disease, Remicade, Ulcerative Colitis, Cimzia, Inflammatory Bowel Disease, Simponi, Infliximab, Etanercept, Adalimumab, Golimumab, Certolizumab

FDA Approves Humira (adalimumab) for the Treatment of Pediatric Patients with Crohn's Disease

Posted 26 Sep 2014 by Drugs.com

NORTH CHICAGO, Ill., Sept. 25, 2014 /PRNewswire/ – AbbVie announced today that the U.S. Food and Drug Administration (FDA) has approved Humira (adalimumab) for reducing signs and symptoms, and achieving and maintaining clinical remission, in pediatric Crohn's disease patients 6 years of age and older when certain other treatments have not worked well enough. This FDA approval represents the eighth indication for Humira in the United States and makes it the first and only biologic treatment approved for use in this patient population that can be administered at home. "Moderate to severe Crohn's disease is a serious chronic disorder that can impact children and adolescents in significant ways during this important stage of their lives," said Jeffrey S. Hyams, M.D., head, Division of Digestive Diseases, Hepatology and Nutrition, Connecticut Children's Medical Center. "The approval of ... Read more

Related support groups: Humira, Crohn's Disease, Adalimumab

Scientists Spot Genetic Clues to Crohn's Disease

Posted 27 Aug 2014 by Drugs.com

WEDNESDAY, Aug. 27, 2014 – A new genetic discovery about Crohn's disease could lead to different ways to fight the bowel disorder, researchers report. The scientists pinpointed chemical changes in Crohn's patients' DNA that affect how their genes work, and said these changes can be detected in blood samples. Along with raising the possibility of a simple diagnostic test for Crohn's, the findings provide new insight into how the disease develops and suggest possible gene targets for new treatments, said the authors of the study. It was published Aug. 26 in the journal Inflammatory Bowel Diseases. Previous research has found several genes linked to Crohn's, but not everyone who has the genes develops the condition. The findings of this new study involving children with Crohn's disease in Scotland suggest that differences in environmental factors among people – such as diet and gut ... Read more

Related support groups: Crohn's Disease

Popular Crohn's, Colitis Drugs Not Linked to Short-Term Cancer Risk: Study

Posted 18 Jun 2014 by Drugs.com

WEDNESDAY, June 18, 2014 – A popular class of drugs used to treat inflammatory bowel disease isn't linked to an increase in the short-term risk of cancer, Danish researchers report. Researchers found that people with Crohn's disease or colitis who received the drugs – tumor necrosis factor alpha (TNF-a) antagonists – had about the same risk of cancer as other people with these inflammatory bowel diseases who were not treated with the medication. The drugs work by interrupting the function of TNF-a, a substance used by the immune system to increase inflammation. "Treatment with these drugs inhibits the inflammatory response in the gastrointestinal tract thereby leading to reduced symptoms," said lead author Dr. Nynne Nyboe Andersen of the Statens Serum Institute in Copenhagen. The problem is that TNF-a also serves a key role in protecting the body against cancer, raising concerns that ... Read more

Related support groups: Humira, Enbrel, Crohn's Disease, Remicade, Ulcerative Colitis, Colorectal Cancer, Cimzia, Inflammatory Bowel Disease, Simponi, Infliximab, Etanercept, Adalimumab, Golimumab, Certolizumab

FDA OKs New Drug for Hard-to-Treat Colitis and Crohn's

Posted 21 May 2014 by Drugs.com

WEDNESDAY, May 21, 2014 – A new drug to treat adults with ulcerative colitis and Crohn's disease has been approved by the U.S. Food and Drug Administration. The agency said Tuesday that injections of Entyvio (vedolizumab) can be used to treat patients with moderate to severe ulcerative colitis and Crohn's disease who have had poor responses to one or more of the current standard therapies: corticosteroids, immunomodulators, or tumor necrosis factor blocker medications. The FDA's approval of the new drug is based on two clinical trials of about 900 patients with ulcerative colitis, and three clinical trials of about 1,500 patients with Crohn's disease. Ulcerative colitis causes inflammation and ulcers in the inner lining of the large intestine and can lead to abdominal discomfort, bleeding and diarrhea. It affects about 620,000 Americans. Crohn's can cause inflammation and irritation in ... Read more

Related support groups: Crohn's Disease, Ulcerative Colitis

Entyvio Approved for Ulcerative Colitis and Crohn's Disease

Posted 20 May 2014 by Drugs.com

TUESDAY, May 20, 2014 – Entyvio (vedolizumab) has been approved by the U.S. Food and Drug Administration to treat adults with moderate-to-severe forms of two gastrointestinal conditions – ulcerative colitis and Crohn's disease. The approval applies to people for whom standard therapies – such as corticosteroids or tumor necrosis factor-blocking medications – have failed. Ulcerative colitis, affecting about 620,000 Americans, causes inflammation and ulcers in the large intestine. This can lead to abdominal discomfort, bleeding and diarrhea, the FDA said in a news release. Crohn's causes inflammation and irritation of any part of the gastrointestinal tract. More than 500,000 Americans have been diagnosed with Crohn's, the FDA said. The most common side effects of Entyvio include headache, joint pain, nausea and fever. More serious adverse reactions observed during clinical testing ... Read more

Related support groups: Crohn's Disease, Ulcerative Colitis, Crohn's Disease - Maintenance, Ulcerative Colitis - Active, Crohn's Disease - Acute, Ulcerative Colitis - Maintenance

FDA Approves Entyvio (vedolizumab) to treat Ulcerative Colitis and Crohn's Disease

Posted 20 May 2014 by Drugs.com

May 20, 2014 – The U.S. Food and Drug Administration today approved Entyvio (vedolizumab) injection to treat adult patients with moderate to severe ulcerative colitis and adult patients with moderate to severe Crohn‘s disease. Entyvio is approved to treat those conditions when one or more standard therapies (corticosteroids, immunomodulators, or tumor necrosis factor blocker medications) have not resulted in an adequate response. Ulcerative colitis is a chronic disease that affects about 620,000 Americans. It causes inflammation and ulcers in the inner lining of the large intestine and is one of two main forms of chronic inflammatory bowel disease. The inflammation can lead to abdominal discomfort, gastrointestinal bleeding, and diarrhea. Crohn‘s disease is a chronic inflammatory condition that causes inflammation, or swelling, and irritation of any part of the digestive tract—also c ... Read more

Related support groups: Crohn's Disease, Ulcerative Colitis

Depression Tied to Crohn's Disease Flare-Ups

Posted 6 May 2014 by Drugs.com

SATURDAY, May 3, 2014 – Depression may increase the risk of Crohn's disease flare-ups in people with the inflammatory bowel disorder, an early new study suggests. The study included about 3,150 Crohn's patients who completed online questionnaires about their disease, its treatment and how it affects their lives. They were also asked about how often they felt hopeless, sad, helpless or worthless. Patients with high depression scores were 50 percent more likely than those with low depression scores to have a Crohn's disease flare-up 12 months later, the researchers said. After the researchers adjusted for other risk factors, the link between depression and Crohn's flare-ups remained significant, according to the Crohn's and Colitis Foundation-sponsored study. It's scheduled to be presented Saturday at the Digestive Disease Week meeting, in Chicago. While the study found an association ... Read more

Related support groups: Depression, Crohn's Disease

Gut Bacteria May Play Role in Crohn's Disease

Posted 12 Mar 2014 by Drugs.com

WEDNESDAY, March 12, 2014 – The community of bacteria that typically live in the human gut is radically altered in patients with Crohn's disease, a new study shows. Overall, patients with Crohn's have less diversity among their intestinal bacteria than healthy individuals. And certain types of harmful bacteria appear to be increased in Crohn's patients, while the amounts of beneficial bacteria are decreased, the study found. Whether those changes are a cause or a consequence of the disease isn't known. But the discovery may help doctors diagnose patients more quickly and it may point the way to new treatments for the disease, which is estimated to affect about 700,000 people in the United States. For the study, researchers recruited nearly 500 patients who were newly diagnosed with Crohn's disease and more than 200 who were having intestinal problems without inflammation. Crohn's ... Read more

Related support groups: Crohn's Disease

Thalidomide May Help Kids With Crohn's Disease

Posted 26 Nov 2013 by Drugs.com

TUESDAY, Nov. 26, 2013 – Thalidomide, a drug made infamous after it caused devastating birth defects in the 1950s, may help treat children with Crohn's disease who haven't responded to other medications, new research suggests. After eight weeks of treatment, more than 46 percent of children taking thalidomide had reached remission, compared to about 11 percent of those given an inactive placebo. And remission lasted longer for the children on thalidomide – an average of 181 weeks compared to just 6.3 weeks for those who took the placebo. The Italian researchers published their results in the Nov. 27 issue of the Journal of the American Medical Association. Funding for the study was provided by the Italian Medicines Agency, while the drug's manufacturer, Celgene, provided the drug for the study. Crohn's disease is an inflammatory bowel disease. It's estimated that about 500,000 people ... Read more

Related support groups: Crohn's Disease, Thalidomide, Thalomid

Crohn's and Colitis May Be Tied to Risk of Heart Attack, Stroke

Posted 14 Oct 2013 by Drugs.com

MONDAY, Oct. 14 – People with inflammatory bowel disease may be at increased risk for heart attack and stroke, a new study suggests. Researchers analyzed data from more than 150,000 inflammatory bowel disease (IBD) patients who took part in nine studies. They found that these patients had a 10 percent to 25 percent increased risk of stroke and heart attack, and that this increased risk was more prevalent among women. Doctors need to be aware of this link and should focus on controlling other stroke and heart attack risk factors, such as smoking, high blood pressure and diabetes, study author Siddharth Singh, of the Mayo Clinic in Rochester, Minn., said in a news release from the clinic. The study was scheduled for presentation Monday at the annual meeting of the American College of Gastroenterology, in San Diego. Research presented at medical meetings should be viewed as preliminary ... Read more

Related support groups: Heart Attack, Crohn's Disease, Colitis, Myocardial Infarction

Drug Shows Promise for People With Colitis, Crohn's Disease

Posted 21 Aug 2013 by Drugs.com

WEDNESDAY, Aug. 21 – An experimental drug may help some people who have inflammatory bowel disease that has failed to respond to current medications, two new clinical trials find. The drug, called vedolizumab, is being developed to treat the two main forms of inflammatory bowel disease (IBD) – ulcerative colitis and Crohn's disease. Both arise when the immune system launches an abnormal attack on the lining of the digestive tract, leading to chronic inflammation and symptoms such as abdominal cramps, diarrhea and rectal bleeding. In the new trials, reported in the Aug. 22 issue of the New England Journal of Medicine, researchers found that vedolizumab worked in some cases where standard IBD medications had failed. The drug was more effective for colitis than for Crohn's, however, and an expert not involved in the studies said he suspects vedolizumab might be approved for colitis ... Read more

Related support groups: Crohn's Disease, Ulcerative Colitis, Inflammatory Bowel Disease

Extra Vitamin D May Ease Crohn's Symptoms, Study Finds

Posted 19 May 2013 by Drugs.com

SATURDAY, May 18 – Vitamin D supplements may help those with Crohn's disease overcome the fatigue and decreased muscle strength associated with the inflammatory bowel disease, according to new research. Extra vitamin D "was associated with significantly less physical, emotional and general fatigue, greater quality of life and the ability to perform activities of daily living," said Tara Raftery, a research dietitian and doctoral candidate at Trinity College Dublin. She is scheduled to present the findings Saturday at the Digestive Disease Week meeting in Orlando, Fla. Raftery and her colleagues evaluated 27 patients who had Crohn's in remission. (Even in remission, fatigue and quality of life can be problematic.) The patients were assigned to take either 2,000 IUs (international units) of vitamin D a day or a dummy vitamin for three months. Before and after the study, the researchers ... Read more

Related support groups: Vitamin D, Crohn's Disease, Vitamin D3, Cholecalciferol, Ergocalciferol, Drisdol, Hectorol, Replesta, Calciferol, Doxercalciferol, Delta D3, Calcidol, D3-5, D400, D2000, D 1000 IU, D3-50

Flu Vaccine Safe for Kids With Crohn's, Colitis: Study

Posted 6 May 2013 by Drugs.com

MONDAY, May 6 – Yearly flu vaccinations are safe for children with inflammatory bowel disease, but too few of these youngsters get a flu shot because their parents worry about possible side effects, researchers report. Not only does vaccination help protect against the flu, it may even reduce inflammatory bowel disease (IBD) symptoms, according to the study, which was published May 6 in the journal Pediatrics. Children with inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis, often experience chronic abdominal pain, diarrhea, joint pain and other symptoms. The researchers looked at all children under age 19 diagnosed with IBD in Ontario, Canada, between 1999 and 2009. They found that about 25 percent of the IBD patients received a flu shot from a doctor or nurse practitioner and that these youngsters had no increase in IBD-related health issues after being ... Read more

Related support groups: Crohn's Disease, Colitis, FluLaval, Afluria, Fluzone, Fluvirin, Flushield, Influenza Virus Vaccine, Inactivated, Flucelvax, Fluarix, Agriflu, Fluzone PFS, Fluzone SV, Fluzone Preservative-Free, Fluzone WV, Fluogen

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