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Does Prilosec cause joint, bone and/or muscle pain?

Answers (3)

22 Aug 2015

Oh my God!! i had the worst pain in my legs. I truly believe this med has strong side effects on bones. If you have arthiritis, please take this med with lot of precaution.

23 Aug 2015

Mine is,more of a agreement than a answer. I have so many of the side effects listed and thankful for all the answers shared here to help me make a decision of weaning off this med


11 Aug 2012


Bone pain is considered a severe side effect of this med, you must seek immediate medical attention.

All the best,


AquariusAnneCA 12 Aug 2012

Yes, yes and yes! Prilosec or Omeprazole the generic for Prilosec is what I took for 12 years. My fingers became distorted, I had gout, my legs are still in some pain but I am weaning off of the medication and my bone pain is so much better, gout is gone, fingers are beginning to straighten out and I am walking better. Also, my shortness of breath is almost gone too... not good medication for me! I am taking a zantac 2 times a day and it is helping the horrible heartburn that came with a vengeance when I first stopped the Omeprazole... consider talking to your doctor to a change and not a PPI (proton pump inhibitor) since this stops your production of acid and causes a lot of other problems... just my opinion.
Aquarius Anne

tmartindub 28 Oct 2012

I was prescribed Prilosec for gerd for several years and after a couple of months I developed joint pain so bad I could hardly walk. I was diagnosed as having onset of arthritis. Purely by accident I missed two doses of Prilosec and the pain was almost gone and immediately came back when I resumed the dosage. During the period of two missed doses, my gerd came back with a vengance, far worse that I had it to start with. PPIs should be taken off the market entirely because of their side effects. Sure, they get rid of the gerd but you are hooked for life unless you wean yourself off it as I did. The pain is improving daily.

AquariusAnneCA 29 Oct 2012

tmartindub, would you mind stating at this time how you are feeling without the daily dose of Prilosec (Omeprazole)? You said you went off of it as I did too. Without the meds, if I am the least bit stressed, or I bend down, or eat something with too much acid, I am in bad pain and have to take a Prilosec. I am so fearful I will get a much worse problem since as you say we get hooked on the darn PPI's. I still get heartburn but not as bad as I did. I was considering the procedure of having the hernia wrapped around the stomach but do not have anyone I know that has had it done. Please let me know how you are feeling and if you are still off the meds Prilosec?
Thank you,

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