Since prednisone is an inactive drug precursor that must be converted to prednisolone in the liver to become active, why is it the most widely used prescribed drug (rather than prednisolone) when an oral glucocorticoid is indicated?
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What's the difference between prednisone and prednisolone?
8 Sep 2011
Probably because doctors have more experience with Predisone than glucocorticoid. Medrol (Methylprednisolone) tends to have less side-effects, so this is also a popular steroid prescribed by doctors.
In my experience doctors usually are most comfortable prescribing medications that they've had long experience with, to avoid malpractice, and just in general because they are more comfortable prescribing medications that they know a lot about.
For example, my Psychiatrist refused to prescribe me Valium simply because he had bad experiences with former patients on the drug, which pissed me off royally, but nothing I could do about it.
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1 answer • 18 Nov 2009
Does one have stronger side effects than the other?
3 answers • 21 Oct 2012
... prednisone because they don't have as much experience with prednisone alone; however,, prednisone has less side effects. I think I'd ...
2 answers • 13 Sep 2013
I react to Prednisone with severe itching, turning bright red and not sleeping for 36 hours. Also react to cortisone with itching and sleep ...
2 answers • 13 Jan 2014