My younger brother has been taking his medication more then prescribed and I would like to know if he does this for a euphoric feeling or not
28 Jul 2012
It has no side effect of euphoria with appropriate use, but I can't find anything about taking more then prescribed. I did find a rather interesting article on it tho that you might find interesting and applicable : Substance use
Ondansetron lowers the cravings for alcohol, especially in early-onset alcoholics. In one cognitive-behavioral therapy study, ondansetron patients with early-onset alcoholism had fewer drinks per day and reported more days without drinking at all, as compared to the other groups in the study. Also of note, individuals with the LL genotype show significant improvements in alcohol misuse when treated with ondansetron, compared with individuals with the other genotypes of the 5HTTLPR polymorphism, who showed no improvement over placebo.
Researchers at the Stanford University School of Medicine have demonstrated that ondansetron might be useful and effective for treating withdrawal symptoms of opioid addictions. Unlike the existing treatments methadone and buprenorphine, it is not itself an opioid. Additionally, it does not require continued supervision like treatment with clonidine.
The original experiment used mice who were injected with increasing doses of morphine, assayed with naloxone and then underwent haplotypic analysis to isolate a gene candidate. HTR3A which codes for the 5-HT3 receptor emerged as the primary candidate, which suggested 5-HT3 antagonist ondansetron as a possible treatment. The researchers were then able to show using an acute morphine administration model the efficacy in withdrawal symptom control in humans.
28 Jul 2012
Just to let you know:
There is no specific antidote for Ondansetron overdose. Patients should be managed with appropriate supportive therapy. Individual intravenous doses as large as 150 mg and total daily intravenous doses as large as 252 mg have been inadvertently administered without significant adverse events. These doses are more than 10 times the recommended daily dose.
In addition to the adverse events listed above, the following events have been described in the setting of Ondansetron overdose: “Sudden blindness” (amaurosis) of 2 to 3 minutes’ duration plus severe constipation occurred in 1 patient that was administered 72 mg of Ondansetron intravenously as a single dose. Hypotension (and faintness) occurred in a patient that took 48 mg of Ondansetron hydrochloride tablets. Following infusion of 32 mg over only a 4-minute period, a vasovagal episode with transient second-degree heart block was observed. In all instances, the events resolved completely.
While all these events were of short duration, probably not a good idea to overdose on this medication. As far as any "high", I seriously doubt there is much reason to take more than the prescribed amount unless you like being dizzy and having constipation.
28 Jul 2012
As an anti-emetic it is like a strong benadryl or dramamine on some ways, and I wondered if its possible he just felt better from whatever med had been making him vomit?
Other that than, I have a vague memory of teenagers abusing dramamine so I guess anything is possible with the right person right med and wrong dose. :-(
- Ondansetron Information for Consumers
- Ondansetron Information for Healthcare Professionals (includes dosage details)
- Side Effects of Ondansetron (detailed)
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