I have tried everything including Botox. I was put on Plaquenil and gained 25 pounds in less than 3 months, I have APS. I didn't have a chance to lose it when I was put on gabapentin for migraines but too high a dose and gained another 20. I have been on nortriptyline for a month and am terrified of gaining more weight. It has helped with my daily headaches and chronic migraines. Has anyone had issues with weight gain? I'm on 10mg daily