Mirtazapine - mirtazapam (stiffness and joint pain)?

Yes. Mirtazapine caused joint inflammation and loss of range of motion in my elbows and shoulders after 2 years of 30mg treatment. Raising my arm to level shoulder height causes pain to this day 3 months off the drug. Not sure how much longer I have to suffer this disability from Mirtazapine

Hello Poppy52,
I too am taking Mirtazapine 15mg at night! My doctor wants me to double the dose now to 30mg. The Joint pain & stiffness is entirely a different matter. I take pregabalin 125 mg a day for Fibromyalgia! Stiffness is also common if you have osteoarthritis, or other joint problems. I have severe lumbar & cervical stenosis and will need to up my medications for pain relieve. How much pregabalin and Mirtazipine do you take?

Take care & feel better!

Mirtazapine has been wonderful in helping me sleep, but over the past couple of years, I've developed multiple joint aches and pains. I've been looked at by several orthopedic surgeons, and none of them see any major problems. I've gone off of mirtazapine for a week or two to see if it makes a difference. It does, but it's minor. I'm now thinking I may have to go off of it long term to see if it helps ease the pain. I can't come up with any other explanations for my pain.

Hi Poppy. Some of these are side effects from taking mirtazapine. I notice you are taking Pregabalin also. These types of drugs have all the symptoms that you’re having as side effects plus more. I found that the side effects outweighed the benefits so I ended up tapering off. I am now depending on natural remedies which for me is working much better. I wish you the best.
Cindy59

Be sure to check the drug interactions with the pregabalin on this sites interaction checker. it is a good tool.

I too have suffered knee joint &/ surrounding muscle pain since taking Mirtazapine. Someone has previously posted (around 2 months ago) on this site with the same problem & several people responded to that post saying they also had increased joint pain with Mirtazapine, so it does seem as if that might be the culprit? My discomfort is generally low level; certainly not enough to cease taking the drug.

Hi, after reading your post I had to respond. I'm 56 & suffer from ever single disorder you listed, plus I struggle with insomnia.The depression & anxiety I say since birth because I can't remember a time I didn't feel down & nervous even in my childhood. The hot flashes two or three years ago, but the muscle stiffness, fatigue, and joint pain is new. I stopped taking the mirtazapine around xmas 2017 because it either completely wiped me out to the point I was scared or didn't do a thing. My dr said the less taken the more sedating it is. This was confusing & made it hard to find the right dosage-- (it was prescribed for my insomnia & I was to take 1/2 to 2 tablets of 7.5mg b 4 bed). Anyway, I wish I knew what's causing my muscle stiffness, fatigue & joint pain. I've been off it too long for it to be caused by the mirtazapine.