I’ve been on Depo for almost 3 years to combat menorrhagia. I was recently diagnosed with HPV due to a Pap smear coming back positive for it and BV last year. I got the HPV vaccine series to make sure I don’t get cervical cancer. I have done everything I possibly can to get rid of the BV, including probiotics, cranberry supplements, boric acid suppositories, never douching, always wearing cotton underwear and increasing my water intake; but my vaginal pH is still over 4.0. In addition, I’m only intimate with my husband, and this is extremely rare due to his own person medical issues. The only other thing I can think of is the loss of estrogen caused by the shot. Am I valid in thinking this and would it be advisable to seek estrogen replacement therapy while on the shot, in order to balance my vaginal flora?