I was diagnosed with moderate to severe Crohn's disease about a year and half ago. At that time, the Drs. put me on 4000mgs of Pentasa, it didn't help. About a year ago they added Prednisone to my meds, 40 mgs a day. I'm still doing 40 mgs a day. I have already lost one tooth and have at least 4 more that are loose. I have ulcers on my tongue and on the roof of my mouth. I have gain about 50 pounds, which is ok because I lost 60 before I was medicated. My face, knees and ankles are swollen and sore. I'm hungry all the time. I don't sleep very much, on average maybe 4 hours a night. I also now have the onset of Osteoporosis and have shrunk an inch so far. But the worst part of my Prednisone usage is the mood swings. I have lost my job as of last fall, just split from the woman I love and moved out and I am very aggressive most of the time. It's tiring and when I'm not aggressive, I'm depressed. Along with my Prednisone, I have been on Metho-trexate and now Humira. All of these different combinations of medicines and I'm in worse shape than I was before being diagnosed.