Skip to Content

How long does it take for plavix to begin working?

Answers (1)

6 Mar 2012

Plavix (clopidogrel) must be metabolized by CYP450 enzymes to produce the active metabolite that inhibits platelet aggregation. The active metabolite of clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet P2Y12 receptor and the subsequent ADP-mediated activation of the glycoprotein (GPIIb/IIIa complex) and that inhibits platelet aggregation. This action is irreversible.

Platelets exposed to clopidogrel's active metabolite are affected for the remainder of their lifespan (about 7 to 10 days).

Platelet aggregation induced by agonists other than ADP is also inhibited by blocking the amplification of platelet activation by released ADP.

Dose-dependent inhibition of platelet aggregation can be seen 2 hours after single oral doses of Plavix. Repeated doses of 75 mg Plavix per day inhibit ADP-induced platelet aggregation on the first day, and inhibition reaches steady state between Day 3 and Day 7. Generally in about 5 days.

So around 3-7 days! :)

-Thomas

dkeeley 3 Jun 2014

Thomas, What is your background? I have a technical question? Damon

Further Information

Search for questions

Still looking for answers? Try searching for what you seek or ask your own question.

Similar questions

Does plavix work for every one ? Have been on plavix for about 8 years. Had open heart bypass Q4?

... about 3 years ago. I keep on getting blockages. Every 3 to 5 months I am back in the hosp.t To date 1/11/11 . I have 7 stentsput in - 3 stents ...

3 answers 13 Jan 2011

How to taper plavix and how long to use plavix?

about plavix treatment

0 answers 29 Jul 2011

Is there a prescription drug for acid reflux that does not interfere with the effects of plavix?

all of the ... prazole meds show that they keep plavix from working properly. Have taken omeprazole, nexium,dexilant, etc.

2 answers 22 Dec 2011

Can you gain weight after stopping Plavix?

I'm on Weight Watchers and my cardiologist stopped my Plavix 3 weeks ago. I had lost 49.4 #s in a year but in the last 3 weeks, I've gained ...

1 answer 7 Feb 2012

Plavix and stents - what is the current thinking on how long I should take Plavix for?

I had 3 stents and was told to be on plavix for at least one year. My cardiologist says I should continue and my primary physician says I could stop. ...

1 answer 12 Mar 2012