Has anyone changed from taking Zoloft to Lexapro and noticed any differences? I have heard Lexapro’s slower release is beneficial. I have taken Zoloft for about 20 years and take the highest dose 200mg so there isn’t much flexibility for adjustment now. I am worried about needing to wean off completely to start on a new medication. (Reducing by 50mg every 2 weeks). Will be doing so under medical guidance.