... used these medications to relieve migraines? I have debilitating migraines and I've tried every medication used specifically for this condition. To name a few... Imitrex, Frova, Treximet, Maxalt, zomig, bupaand the list goes on. All were uneffective. Also in an effort to prevent them i was prescribed topamax & Elavil. They were ineffective as well. My migraines are more frequent the older I get. It's taken a toll on my daily life, responsibilities, and priorities. Has the tramadol Been effective in treating migraines for anyone else out there and if so are are u taking it alone or with another medication?