23 Nov 2009
Antabuse (disulfiram) is a prodrug.
Absorption of disulfiram from the gastrointestinal tract is rapid but incomplete and approximately 20% is excreted in the faeces. Because of its high lipid solubility, disulfiram is widely distributed and accumulated in various fat depots. Disulfiram is rapidly metabolised to diethyldithiocarbamate (DDC), which is partly excreted as carbon disulfide in the expired air and is partly metabolised in the liver to Me-DDC. Me-DDC is metabolised further to the active metabolite Me-DTC (diethylthiocarbaminic acid methyl ester). The concentration of Me-DTC reaches its maximum after about four hours, but the maximum enzyme inhibiting effect (aldehyde dehydrogenase (ALDH)) is first reached after three daily doses. The plasma half-life for Me-DTC is about ten hours, but the enzyme inhibiting effect of ALDH lasts considerably longer. The effect can thus persist for 7 to 14 days after discontinuation. In patients receiving disulfiram maintenance treatment, the ingestion of alcohol brings about a typical disulfiram-alcohol reaction within the course of five to ten minutes. Metabolism is not appreciably affected by a mild to moderate decrease in hepatic function. The metabolites are chiefly excreted with the urine. A part is recovered in the expired air as carbon disulfide.
Up to 20% of a dose may remain in the body for one week or longer.
- Antabuse Information for Consumers
- Antabuse Information for Healthcare Professionals (includes dosage details)
- Side Effects of Antabuse (detailed)
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
I can't believe that one pill that you have never taken before can stay in your system up to 7 days. I've never heard of anything like ...
3 answers • 23 Dec 2009
my friend is in a lot of pain and was prescribed them but is fighting a battle for her kids need to know how long it will stay in her system
3 answers • 25 Jul 2010
How long does Antabuse stay in a person system? How many days can laps before a person can take a drink and not get sick?
1 answer • 7 Jun 2011
My son had an addiction and was sent to a detention center for 5 days. He had not done them for 6 days but when he got out, he tested positive for ...
5 answers • 2 Aug 2011
ive been taking 200mg of antabuse in the morning s for a slight wine at night problem 3-4 nights a week that was just a habit its been a month on it, ...
2 answers • 1 Nov 2013