I always thought you divide the day by those times and that would give you the amount of hours the medicine would stay on your system however my child just heard from her doctor "the 4 times a day" would be considered the awaking hours only??? So, if I am awake 16 hours that medicine would be taken every 4 hours, and if my child sleeps 12 hours during the disease she would take even 3 hours??? Even being half of my size???