Do you guys take Wellbutrin SR/XL on an empty stomach?

I am loving Wellbutrin SR. Have battled depression and ADD for years. Doctors prescribed it to me and I've picked up pills twice (10 years ago, 4 years ago) but ended up not taking it. This time around I did - it's only been 3 weeks but I'm amazed by the difference in motivation (way up), attitude (calmer, patient, enthusiastic) and energy.

As far as answering your question, I notice that if I take it and then have food immediately afterwards, it doesn't really give me that nice kick as when I don't eat afterwards for about 1.5hours. I also try to take it at least an 1.5hours after breakfast. And I noticed that it takes about an hour for it to start kicking in. It is very subtle, nothing like empty exhilaration of amphetamines.

I take it first thing in the morning 150mg extended release with a glass of water

My pharmacist did not mention anything about taking wellbutrin with food. HOWEVER, through trial and error, I learned the hard way that alcohol Is intensified while on wellbutrin. I avoid alcohol all the time now. Weirdly enough, a cup of coffee with my wellbutrin seems to make a slight difference in a little extra motivation. Just take it the same time everyday and don't be your own shrink. Consult ur dr before tinkering with dosages because I experienced scary psychological side effects trying out doubling my dosage. Bad idea, worst weekend of my life til al that crap finally came out of my system. Good luck to you! And wellbutrin is not for everyone but I'm so happy God planned things perfectly to get the treatment I needed to be a better wife daughter sister aunt! Everyone is speechless by my recovery. Don't stress though if u backslide. Just pick yourself back up and start all over tomorrow!! God bless!!!

Hey hope,

Just to give you the technical answer to your question about food and its effect on Wellbutrin (bupropion), I share the following from the literature

"Following oral administration of Wellbutrin XL Tablets to healthy volunteers, time to peak plasma concentrations for bupropion was approximately 5 hours and food did not affect the Cmax or AUC of bupropion."

So bottom line, food doesn't affect the absorption of Wellbutrin. I take mine with a big ole spoonful of oatmeal. Yummy and it works great. lol

Laurie

Hello hope31. When I was taking wellbutrin, as most meds that I've been on, generally, as soon as I've risen for the day, glass of water and pill time. Aside from my "night" medication, its always been the med. and water. Best to you.

I take the XL version and it can be taken with or without food, I take mine in the mornings without food and feel just fine.