19 Mar 2011
Interactions between your selected drugs
lithium ↔ caffeine
Applies to: lithium, caffeine
MONITOR: One study has suggested that caffeine withdrawal may significantly increase blood lithium levels. The mechanism may be involve reversal of a caffeine-induced increase in renal lithium excretion.
MANAGEMENT: When caffeine is eliminated from the diet of lithium-treated patients, caution should be exercised. When caffeine consumption is decreased, close observation for evidence of lithium toxicity and worsening of the psychiatric disorder is recommended. Patients should be advised to notify their physician if they experience symptoms of possible lithium toxicity such as drowsiness, dizziness, weakness, ataxia, tremor, vomiting, diarrhea, thirst, blurry vision, tinnitus, or increased urination.
Other drugs that your selected drugs interact with
caffeine interacts with more than 30 other drugs.
lithium interacts with more than 500 other drugs.
Interactions between your selected drugs and food
caffeine ↔ food
Applies to: caffeine
The effect of grapefruit juice on the pharmacologic activity of caffeine is controversial. One report suggests that grapefruit juice increases the effect of caffeine. The proposed mechanism is inhibition of cytochrome P-450 metabolism of caffeine. However, a well-conducted pharmacokinetic/pharmacodynamic study did not demonstrate this effect. The clinical significance of this potential interaction is unknown.
19 Mar 2011
No, in fact, it is possible to cause more harm then good by stopping your usual intake of caffiene such as coffee. As Maso pointed out, it is the reduction in caffiene that can cause the problem.
If you are going to change the usual amount of caffiene consumption then you will have to have your blood levels checked frequently to insure you don't cause a toxic level of Lithium to develop in the blood.
Hope this helps,
19 Mar 2011
I have been taking lithium since I was 10. Yeah, I know a long time and major for a kid. Thing is it NEVER worked for me. I rarely ever had any lithium in my blood work. Years later I found out lithium + caffeine is bad. It blocks the absorption of the lithium in your body. Hence why if you cut down it can cause too much. Caffeine while taking lithium is bad but only if you want it to work. I have been caffeine free for 6 years now (with the occasional soda and unleaded coffee) and feel great. I have never felt as though the meds have worked this well in my whole time of taking them. Hope this helps.
- Lithium Information for Consumers
- Lithium Information for Healthcare Professionals (includes dosage details)
- Side Effects of Lithium (detailed)
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