I heard that there were possible drug interactions if you take plavix and cymbalta together.
8 Aug 2009
It would be best to avoid taking Plavix and Cymbalta together, unless you absolutely need to. If you do have to take them together then you should be monitored.
Plavix (clopidogrel) and Cymbalta (duloxetine) have a moderate drug-drug interaction.
Serotonin reuptake inhibitors (SRIs) may potentiate the risk of bleeding in patients treated with agents that affect hemostasis such as anticoagulants, platelet inhibitors, thrombin inhibitors, thrombolytic agents, or agents that commonly cause thrombocytopenia. [ Plavix is an anticoagulant and Cymbalta is a selective serotonin and norepinephrine reuptake inhibitors (SSNRIs)].
MANAGEMENT: Caution is advised if SRIs are used in combination with other drugs that affect hemostasis. Close clinical and laboratory observation for hematologic complications is recommended. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.
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