13 Aug 2010
Ibuprofen is an anti-inflammatory, or in the NSAID family, this is different from acetaminophen, so they can be taken together, without incident. They are two completely different medications. It may cause some stomach upset, so I would maybe have a few crackers or something on your tummy before taking this med. I have to do this with almost any med, just a word of advice. Always check it out, better always to be safe than sorry I wish you luck friend. Bless You
14 Aug 2010
It is dangerous to combine acetaminophen with Ibuprofen. Because one of my meds has acetaminophen in it I do not take Tylenol for any reason and if I have a headache or anything that doesn't have to do with my chronic pain disease I will take Advil (Ibuprofen) separately but not at the same time.
Be careful and please check as Advil is harder on the liver and acetaminophen is harder on our kidneys. You can go back and forth but I wouldn't do both at the same time especially in prescription strength.
16 Jan 2015
This is acceptable because Tylenol 3 (30g codeine/300mg acetaminophen) is metabolized in the Liver and ibuprofen/Advil/Motrin is detoxed by the kidneys. You'll probably have enough synergistic pain relief with combining with Tylenol 3 so 600mg ibuprofen should be sufficient enough to notice its additional anti-inflammatory effects. BTW 650-1000mg Tylenol is a normal to high dose range so 300mg a small dose anyway. Its the codeine (opioid) you should be more concerned about if you're combining it with excessive alcohol or other opioids. Codeine is ok to take with ibuprofen at their typical recommended dosages..
(1)Dr. Paul A. Moore, chair of dental anesthesiology at the University of Pittsburgh in Pennsylvania:
"Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, work by blocking the synthesis of prostaglandins, suppressing both inflammation and pain, the researchers note. In contrast, acetaminophen does not suppress inflammation and appears to suppress pain through multiple other mechanisms. Increasing doses of these drugs can increase their effectiveness only up to a point, and high doses can be toxic, but the 2 together can suppress pain better than either alone, the authors write."
*This is for informational purposes only it does not replace the advice of your personal medical professional.
- Acetaminophen Information for Consumers
- Acetaminophen Information for Healthcare Professionals (includes dosage details)
- Side Effects of Acetaminophen (detailed)
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