Im 16 and have had this type of issue all of my life. I used to take 450mg of bupropion (Wellbutrin) but after 7-8 months or so I started feeling as though the medication wasn't helping anymore, I would become very down, angry, irritable and agitated. I was told to stop taking it by my Dr. Once I was off of Wellbutrin I would have crying spells and panic attacks and I felt very sick. I now take 20mg of celexa (3rd week taking it) I already feel slight improvement but rather sick. I also have a low thyroid and take levothyroxyn for it (8-9 months taking it) what's best for generalized anxiety and depression?