My gastro prescribed two 25mg of amitriptyline at night to start for my IBD D. This seems like a high dose, she said she was giving me a low dose. My two concerns is weight gain and is the dose too high? I’m scared to start the medication because you can’t Just stop it. I took Zoloft once and had a horrible experience and weight gain that took years to come off since it messed up my metabolism. Does this mess with your thinking as well? I just don’t want the side effects to be a new slew of problems added to my severe IBS. I have it all day everyday and gets worse with age! I can’t do anything. I hope someone can address my concerns I’d greatly appreciate it. I need my life back!