Hi, I started 25mg Zoloft about 2 months ago, after the first month I increased it to 37.5mg- I’m beyond exhausted. Just saw my doc who recommended going back down to 25mg as I’m very sensitive to ALL psych meds. I did see improvement on the 25mg. Has anyone else had this low dose help depression? I’ve tried Effexor, Pristiq, and Wellbutrin & Prozac which did NOTHING. In fact the Wellbutrin put me in the hospital. I’m at a loss & hoping lowering to the 25mg will eventually cause the fatigue to go away. I take around 5pm- this is the only time I can seem to remember.
Has anyone had success on 25mg Zoloft?
Question posted by crazygirl66 on 4 July 2018
Last updated on 10 December 2018
3 Answers
Newmeds19
10 Dec 2018
I just started zoloft 25mg and i don't know if it's working for me. It's only been a week, I take it in the morning because that's when I feel anxious and i take .25 xanax on top of it. The side effects are ridiculous for me, so much nausea all day and insomnia at night despite taking ambien CR. I am hoping the low dose works because I am scared of an increase because of the symptoms.
Let me know how you do and good luck!
crazygirl66
10 Dec 2018
I’m still only taking 25mg, I’d say it’s helped my depression 70%. I did have very restless sleep the first few weeks but mentally felt better after about 2 weeks. I still have no motivation & am tired but not completely exhausted. So for now I’m sticking with it as nothing else I’ve taken before helped at all... the nausea for me was gone in a few weeks.
Smileyfaces008
5 Dec 2018
Well how are you doing now? Im on 25mg of zoloft... been about 20 days. I started to notice a little change a few days ago but not sure how well this is working. I was thinking of going to 37.5 mg being maybe im not close enough to the therapeutic dose. The side effects have been insane..im very nervous if I increase... the side effects will return with a vengeance. Its been a while hopefully you have an update
crazygirl66
5 Dec 2018
I’m still on the 25mg, I’m still also a bit tired but unfortunately my body will never lose that side effect. When I’m PMSing I do notice my mood does go down, ocd gets worse & slightly more anxiety but I can’t even take birth control pills because they make me crazy depressed. I’d say the 25mg has helped about 70% otherwise, no other side effects. Give it a good full month before you increase, some people do better on less, I’m one of them, but we never know until we try...
Kynyada37
6 July 2018
I can only speak for myself, Zoloft wasn't good for me. I have had serotonin syndrome so had to come off all meds. Have you heard of Trintellix? It's a lower dose but seems to be highly effective in most cases. It's not the same as other meds
I wish I could be more help but please stay away from cymbalta. It's absolutely ridiculous to come off of.
crazygirl66
6 July 2018
Have you had side effects? I’ve tried multiple meds & this one helps a bit, I’m just damn exhausted!
Related topics
zoloft, depression, post traumatic stress disorder, obsessive compulsive disorder, panic disorder, premenstrual dysphoric disorder, major depressive disorder
Further information
- Zoloft uses and safety info
- Zoloft prescribing info & package insert (for Health Professionals)
- Side effects of Zoloft (detailed)
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