I was diagnosed with Rheumatoid arthritis in mid 2012. I have tried prednisone, methetrexate, arava, humira, and now they are going to start me on Simponi soon. Has anyone tried this biologic and have you had success. I have been getting flare ups of Iritis in my eyes from the RA. Humira did not control this after 8 months. I am also so tired all the time and feel extremely depressed. They put me back on prednisone, and steroid eye drops for now to help control the Iritis as it can cause blindness.