Evolocumab for Cardiovascular Risk Reduction User Reviews (Page 2)

• AMS
• Taken for less than 1 month
• September 10, 2019

Repatha (evolocumab) "One injection and I am not going to take it again. First chills then horrible muscle pain in upper chest and neck. Gained 6 lbs in two weeks. Put me on edge. Still suffering. Woke up in middle of night with more pains. Only a pain killer helped. I do not believe in the LDL theory anyway. "

• Jody
• June 3, 2019

Repatha (evolocumab) "HORRIBLE DRUG .. Took only 2 shots, 2 weeks apart and am having horrible side effects. Should never have taken the second shot as I already had side effects after 4 days but was told by my cardiologist that they weren't life threatening and I should take the 2nd shot .. worst mistake!! I have burning sensation in my bones of my hands, knees, feet .. it wakes me up from a sound sleep. Also have blurred vision, totally fatigued, brain confusion, itchy and stomach problems. Was told by a nurse at Amgen that it can take up to 120 days to detox .. hopefully everything will go back to normal after that but reading up on some other comments it may not be so!"

• Anonymous
• Taken for 1 to 6 months
• October 20, 2019

Repatha (evolocumab) "I have been taken Repatha 3 and 1/2 months. at first I was fine my cholesterol went down and by the third month I was getting blurred vision headaches severe fatigue burning in the feet muscle pain in my back of neck it's gotten to the point where I can't even work I'm so, so tired, short of breath, wheezing, urinating a lot although my cholesterol went down it's not worth taking Repatha if there's no quality of life for me"

• JJano
• September 19, 2019

Repatha (evolocumab) "The day after taking Repatha my blood sugar soared to 450 just days after a 6.2 A1C result. The worst part is that when I reported this to my cardiologist the reaction was gee we did not know that was a side effect. The same response came from the Cardiology department. Hard to fathom that they didn't know about a side effect that is listed on the reaptha.com website in plain English. Tells you something about how informed the Doctors are - and we rely on their knowledge. Funny just after my experience Repatha price dropped ...that pretty much tells the tale"

• Frust...
• Taken for 1 to 6 months
• December 6, 2018

Repatha (evolocumab) "49 yr old male that had stemi (ST-segment elevation myocardial infarction ) heart attack. Two stents placed in LAD and RCA arteries. Hypothyroid, diabetes, high cholesterol, HTN. Treated 2 yrs ago with statin drugs and a had a serious reaction. Started with paranoia and mood disorder. Stopped the statin drug for 3 weeks and was placed on another statin drug and suffered from full blown psychosis. As to this day he still has to take antipyschotic meds. So my concern was starting Repatha and going through these same symptoms. The nurse assured me he should not have that type of reaction. Well after the first dose of Repatha I thought everything was good. Some paranoia returning but subsided as the drug began to wear. 2nd dose after two weeks paranoia has returned. Will consult family practitioner and cardiologist before next dose. If this drug has same rare side effects as statin and not reversal I will seek an attorney."

• Rcris...
• Taken for 1 to 6 months
• December 12, 2019

Repatha (evolocumab) "I took three doses of Repatha on a two week regimen as instructed. Within several weeks I began having severe right side gastrointestinal issues. My Liver enzymes shot up quickly. The Doctor indicated that this was not from Repatha. However, after 69 years I do not believe in coincidence. I stopped the drug and, to date, the enzymes are SLOWLY declining. However, I have severe pain. 14 blood tests, a MRI, two ultra sounds and a CT Scan in a five week period show a few cysts but nothing major. The pain is so rough that I will have an Endoscopy next week. While I am thrilled that the tests have looked good I remain quite concerned because of the constant pain. There is no way to determine if Repatha is the culprit. However, I will state again that this all started within days of starting this drug."

• James...
• Taken for 1 to 6 months
• November 27, 2018

Repatha (evolocumab) "I commented about 10 weeks back. First week a few minor blips, but after second week a background flu thing going on. I also noticed exacerbation pain of many old injuries. After the second injection I began to deteriorate, I noticed some mild difficulty swallowing and feeling of fullness very quickly with meals. The flu feeling got much worse and I started to get a general arthralgia. After the third injection I was in trouble with back ache, burning when urinating, diarrhoea, back pain, tenderness in all muscle groups and my heart was skipping beats. I felt absolutely dreadful, my consultant stopped repatha immediately. He declared cogently (urgently) that this reaction was not common. I do have a rare genetic muscle disorder which is subtle. He is just not confident to say that repatha had caused the problems, but did agree that it may be linked. I can only say that my experience with repatha was dreadful. Will update second time around. Best Jim"

• TINA
• Taken for 1 to 6 months
• September 10, 2018

Repatha (evolocumab) "I had 7 injections of Repatha because I could not tolerate oral statins. It lowered my cholesterol & LDL, & HDL went up. Developed stomach & intestinal pain so severe I had to go off of the necessary meds e.g. Plavix & aspirin after 5 stents & had to go to ER. Cardiologist asked me to stop Repatha."

• Joe
• Taken for 1 to 6 months
• May 1, 2019

Repatha (evolocumab) "I have to admit it definitely lowered my cholesterol. But the side effects were unbearable for me. I suffered from unbelievable back pain. I do have a bad back. But doesn’t cause me much issues. But after my third injection the back pain was unbelievable. So I didn’t do another injection and took about a month to get out of my system. Back pain was completely gone. So I decided to give it another shot. I did another injection within about four days back pain came on with a vengeance. I have read many other people complain about this. It seems to affect people with bad backs"

• Paty
• November 12, 2018

Repatha (evolocumab) "I was one of the original people on the blind study. At the time I was a caretaker and I started getting terrible back pain but I attributed it to lifting my husband. The pain continued. After a year my husband passed and my back pain got worse and then the leg pain started. I went to many doctors and no one could find a problem. I even had cortisone shots which did not help. After researching all my medications I finally came to the conclusion that it might be repatha. I decided to stop it for a few months. It didn’t seem to stop but it did get a little better but not enough for me to stop it altogether. I decided to go back on. Two months later after four shots it is worse then ever. I can hardly walk. After reading some more I realized that I didn’t give it enough time. I am going off it again. Hopefully the pains will go away. I read that it could take up to a year to completely go away if at all. When I was on the drug the expense was covered by the study. I am still on it."

• Kinewah
• Taken for 6 months to 1 year
• February 9, 2019

Repatha (evolocumab) "This drug is a lifesaver for me. Vegetarian for over 20 years and still had blockages in heart and carotid artery and had heart attack. Statins were not tolerable at all as I suffered from severe cramps in my entire legs and hands which were so severe I had to stop. Now on Repatha, Lipid profile is fantastic. I stay hydrated and have had zero side effects on Repatha."

• Tom
• Taken for 1 to 6 months
• May 13, 2022

Repatha (evolocumab) "It has been three years since I stopped taking Repatha injections. I started after receiving a stent. I have been a very active athletic person until Repatha. This drug has stolen three years of my life. I am just now feeling I can get back to a semi normal active life. This is a poison that will inflame, destroy, and alter your life for the worse. It will make you feel like you are dying. I am so sorry I agreed to take these shots."

• Horac...
• Taken for 1 to 6 months
• May 16, 2020

Repatha (evolocumab) "I have taken five shots of Rapatha due to CAD and so far I have had no side effects. I would like to mention for those looking to lower the LDL to look into a natural solution called Bergamot. My LDL was at 183 In Dec 2019 and in five months I’ve brought it down to 11. It went from Dec 2019 183 Mar 2020 76 May 2020 11 So from Dec 2019 to March 2020 it dropped 107 point and I was NOT taking the Rapatha shots yet. I started the Rapatha in March 2020 and it is now at 11. It must have helped but without the Rapatha my LDL was dropping like a rock. Regarding my Rating, I will not know how effective it has been for my CAD until I have another Calcium Score so this rating is iffy at best."

• Anonymous
• September 3, 2019

Repatha (evolocumab) "My husband has been off the Repatha for 9 months. He is still feeling the numbness in his feet. Also, feels like his feet are freezing. His legs don't want to work all the time. Pains up and down his legs. He had a heart attack last year and right before he was put on the Repatha he was up to a mile walking. He can barely walk 1/4 mile without still being in pain and exhausted. Only took the shot 3 times. By 3rd shot he couldn't walk."

• Baker
• Taken for 1 to 2 years
• September 16, 2018

Repatha (evolocumab) "Have attempted to use Repatha as I am unable to take any other statin drugs. Have been attempting to use the drug for over a year now, having suspended use a couple of times first due to a serious gastric event and then due to the flu. Have now determined that it is the Repatha that is giving me flu symptoms even if I only inject once a month. 7 to 10 days after the injection I develop a severe sore throat followed by two weeks of sinus congestion and sometimes laryngitis."

• Double...
• Taken for less than 1 month
• December 16, 2018

Repatha (evolocumab) "Injected Repatha for the first time this past Tuesday. Despite all the trouble I have had with statins and blood pressure meds in general, I naively thought the new blazing headaches waking me at night were sugar bonks. I have also lost both energy and focus, and have low grade body aches the life-long day. And forgive me, I almost forgot the tapping noise in one ear that comes and goes. Maybe I'll have the tree decorated by next Christmas, assuming I don't stay away from this stuff!"

• keithy
• Taken for 1 to 6 months
• July 16, 2022

Repatha (evolocumab) "I'm from the Uk I wasn't tolerant to statin tablets. I had started on 80mg astorvastatin then my dose went down to 40mg . I then got changed to pravastatin 10 mg - still no joy joint pains all the time. I was then put on Repatha and within 2 weeks my cholesterol went from 5.3 down to 3.4 no side effects. That was early days but then over the weeks my joints started to hurt, I had constant headaches, UTI infections, collapsed lung , throat infections post nasal drip severe low back pain. I can't walk from one end of the house to the other with out pain. I have chest pain but I also suffer muscleoskeletal issues so hard to say if its Repatha causing that pain but it prob is. I got blurry vision, now a tingling in left arm and leg, and sometimes in the face. I've done urine tests has shown my liver has issues. Now 16/7/2022 3.28 am and I haven't slept properly for months due to my anxiety and depression being at an all time high. I just don't know which way to turn. I get no help from GP or hospital and don't no who to report it to."

• 82nd ...
• Taken for less than 1 month
• April 11, 2019

Repatha (evolocumab) "The Repatha Sureclick Autoinjector appears to have injected the medication directly into my muscle. YOUCH! The pain was extreme. I have experience self-administering subcutaneous injections for over 15 years with biologics for Rheumatoid Arthritis. In over 500 self-injections, I never experienced anything like this. The other problem was Amgen was completely unhelpful. They could only read from a script and tell me only to administer the drug subcutaneously. Unfortunately, if you follow the instructions of stretching the skin and firmly pressing down, it appears enough subcutaneous tissue is pushed a way exposing the muscle. USE THE PINCH METHOD. The company was not helpful and only made me feel worse. They could only read from a script and could not tell me if an intramuscular injection posed any danger or potential problems. Thanks Amgen."

• Old...
• Taken for 1 to 2 years
• June 19, 2019

Repatha (evolocumab) "Mechanical problems are common with the sure-click injector. The pressure leaks out after the button is pushed and the medicine is not delivered. Two of the last 26 have been defective. Make sure your pharmacy will replace defective ones. Not all will do so since there is no written Repatha warranty."

• Big...
• Taken for less than 1 month
• November 4, 2018

Repatha (evolocumab) "I have taken my second shot of Repatha today, Sunday November 04, 2018. I had a lot of negative issues after my first shot including inability to focus, vision issues, malaise, and back pain. I have contracted some type of chest cold and am now on an antibiotic. I do not know if it was Repatha related. I will report back after another week to update you."

• Deane
• Taken for 2 to 5 years
• September 29, 2019

Repatha (evolocumab) "Have been on repatha, 140ml every two weeks, since February 2019. Before that, I was on about the same dose of praluent for about 2 and a half years. My Medicare drug provider did not approve praluent, so had to switch. Cardiologist says they are basically the same thing. Have never had any problems in either one. And along with the statin and ezetimibe, my cholesterol numbers are nearly negligible. Also, although I have been borderline diabetic for a couple decades, I am still below 6.2."

• Joe
• Taken for 6 months to 1 year
• October 30, 2022

Repatha (evolocumab) "In addition to all the negative side effects I've read here and experienced for myself, after taking Repatha for about 10 months, I'm feeling moderately depressed and tired. My get up and go has got up and went. Constant fatigue, brain fog and zero desire to leave the house. In short, Repatha is ruining my life. While Repatha is very effective at lowering cholesterol ( I'd give it a 10+ for effectiveness), however, it's not worth it to me to continue taking it."

• Del...
• Taken for 2 to 5 years
• June 18, 2019

Repatha (evolocumab) "58 yr. old male here. I've taken Repatha for over 2 years and it has dropped my LDL to < 30 - so it certainly works. I haven't experienced any issues, but note that at 56 yrs. old I have experienced an increase in arthritic problems - but can't correlate to Repatha. Elaborating further, I was diagnosed with Psoriatic Arthritis, but know that I struggled with Osteo Arthritis for decades. I had a shoulder replacement 10 yrs prior to Repatha, and 3 knee scopes up to 20 yrs prior."

• lol...
• Taken for 1 to 2 years
• May 1, 2022

Repatha (evolocumab) "First of all I just retired as a Clinical Nurse Educator of 35 yrs. I have a family history of high cholesterol and blood pressure. My dad died at 55, my mother had Quadruple bypass at age 70 due to untreated high cholesterol over 400 (she survived and is 90 in May). Neither were overweight or had high blood pressure. My brother 58 just died in February 2022 from CHF and nonfunctional Aortic valve due to untreated high blood pressure. My concern was to do everything possible to live longer, healthier and I am the oldest sibling. In Jan 2021 new cardiologist did a Heart Catscan to check for calcium blockages in heart coronary veins. The test was free as UH hospital of Cleveland was doing heart research. My LAD (Widow maker) had a mod blockage so started on Repatha. 15 months later, brain fog, muscle aches/weakness, lethargy, forgetting where I’m at in stores! On Crestor 5mg now and symptoms resolving."

• Mauikid
• Taken for 6 months to 1 year
• October 26, 2018

Repatha (evolocumab) "Have had great results but have a continuing problem with sneezing and running nose, also back pain and dizziness. Went to allergist and checked nothing wrong there. Problem always gets worse after shot."