Qulipta
Generic name: atogepant [ a-TOE-je-pant ]
Drug class: CGRP inhibitors
What is Qulipta?
Qulipta (atogepant) belongs to a class of medications called calcitonin gene-related peptide receptor (CGRP) antagonists. CGRP is a protein found in the brain and nervous system that is thought to contribute to the pain, inflammation, and vasodilation associated with migraine attacks.
Qulipta is a prescription medicine used in adults to help prevent migraine headache (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound or light).
Qulipta works by blocking the action of the CGRP protein in the body. This helps prevent migraine headaches.
Warnings
You should not take Qulipta if you are allergic to atogepant.
Take Qulipta as directed. Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: carbamazepine (Carbatrol, Equetro, Tegretol, Teril, others), clarithromycin, cyclosporine (Gengraf, Neoral, Sandimmune), efavirenz (Sustiva, in Atripla, in Symfi), etravirine (Intelence), itraconazole (Sporanox, Tolsura), ketoconazole, phenytoin (Dilantin, Phenytek), and rifampin (Rifadin, Rimactane).
Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with atogepant, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
Also, tell your doctor what herbal products you are taking, especially St. John's wort.
Before taking this medicine
To make sure Qulipta is safe for you, tell your doctor if you have ever had:
-
kidney disease (or if you are on dialysis); or
-
liver disease.
In animal studies, atogepant caused pregnancy problems such as low birth weight or birth defects. It is not known if these effects could occur in humans. Ask your doctor about the risk.
Having migraine headaches during pregnancy may increase the risk of dangerously high blood pressure that can lead to medical problems in both mother and baby. The benefit of preventing migraines may outweigh any risk.
Tell your doctor if you are pregnant or plan to become pregnant.
Ask a doctor if it is safe to breastfeed while using this medicine.
Qulipta is not approved for use by anyone younger than 18 years old.
How should I take Qulipta?
Take Qulipta exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.
You may take Qulipta with or without food.
Store at room temperature away from moisture and heat.
Dosing information
Usual Adult Dose for Migraine Prophylaxis:
-
10 mg, 30 mg, or 60 mg orally once a day .
Use: For the preventative treatment of episodic migraine.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Qulipta?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Qulipta side effects
Get emergency medical help if you have signs of an allergic reaction to Qulipta: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Common Qulipta side effects may include:
-
feeling tired; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Qulipta?
Tell your doctor about all your current medicines. Many drugs can affect atogepant, especially:
-
an antibiotic such as clarithromycin or rifampin;
-
antifungal medicine such as itraconazole or ketoconazole;
-
antiviral medicine to treat HIV, such as efavirenz or etravirine; or
-
seizure medicine such as carbamazepine or phenytoin.
This list is not complete and many other drugs may affect atogepant. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Ingredients
Active ingredient: atogepant
Inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, mannitol, microcrystalline cellulose, polyvinylpyrrolidone vinyl acetate copolymer, sodium chloride, sodium stearyl fumarate, and vitamin E polyethylene glycol succinate.
Manufacturer
Forest Laboratories Ireland Ltd for AbbVie Inc., Dublin, Ireland.
Popular FAQ
Ubrelvy, Qulipta and Nurtec ODT are all medicines used by adults for migraines. They are all from the same group of medicines often called gepants but their full name is calcitonin gene-related peptide (CGRP) receptor antagonist. Continue reading
You may lose some weight if you are taking Qulipta. Studies in over 2,600 patients have shown that 3.2% to 5.3% of patients taking Qulipta lost at least 7% of their body weight, compared to 2.5% of those taking an inactive pill (placebo). As an example, a 7% weight loss in someone who weighs 150 lbs (68 kg) is 10.5 lbs (5.3 kg). Continue reading
Qulipta can begin working on the first day of treatment to help prevent your episodic migraine headaches. Researchers observed that 88% (185 / 211) patients did not have a migraine the day after taking a Qulipta 60 mg dose, compared to 75% (151 / 202) taking an inactive placebo pill. Continue reading
No, Qulipta (generic name: atogepant) did not lead to hair loss (alopecia) during clinical trials submitted for FDA-approval. Qulipta is an oral CGRP receptor antagonist (gepant) used to help prevent migraine headache pain. Hair loss is not listed as a side effect in its FDA-approved product label. Continue reading
Take your prescribed dose each day at about the same time, with or without food. Some people feel tired or sleepy when taking Qulipta. If this occurs, ask your healthcare provider if you can take your dose at bedtime. If you feel nauseous, take your daily dose at mealtime. Continue reading
Qulipta, a preventive migraine treatment, has been shown in studies to lead to a 54% reduction in monthly migraine days in patients with episodic migraine (a 4.2-day reduction) and a 36% reduction in patients with chronic migraine headaches (6.9-day reduction). Continue reading
Qulipta works by blocking a key protein in your body called calcitonin-related gene peptide, or CGRP, to help prevent migraine headaches and the transmission of pain. Qulipta belongs to the gepant class of CGRP receptor antagonists and is intended for oral administration. Continue reading
More FAQ
References
More about Qulipta (atogepant)
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (121)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Support group
- FDA approval history
- Drug class: CGRP inhibitors
- Breastfeeding
- En español
Professional resources
Related treatment guides
Further information
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Qulipta only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2024 Cerner Multum, Inc. Version: 1.01.
