Risk for Intracerebral Hemorrhage May Be Transmissible Via Blood Transfusion
Medically reviewed by Drugs.com.
By Elana Gotkine HealthDay Reporter
MONDAY, Sept. 18, 2023 -- The risk for spontaneous intracerebral hemorrhage (ICH) is increased for patients who receive red blood cell transfusions from donors who later develop multiple spontaneous ICHs, according to a study published in the Sept. 12 issue of the Journal of the American Medical Association.
Jingcheng Zhao, M.D., Ph.D., from Karolinska Institutet in Stockholm, and colleagues conducted a retrospective cohort study using nationwide blood bank and health register data from Sweden (main cohort) and Denmark (validation cohort) including 1,089,370 patients aged 5 to 80 years who had received a red blood cell transfusion (759,858 from Sweden; 329,512 from Denmark), with a median follow-up of 5.8 and 6.1 years, respectively.
The researchers found that compared with patients receiving transfusions from donors who did not develop spontaneous ICH, those who underwent transfusion with red blood cell units from donors who developed multiple spontaneous ICHs had a significantly higher risk for a single spontaneous ICH themselves in both the Swedish and Danish cohorts (adjusted hazard ratios, 2.73 and 2.32, respectively). No significant difference was seen for patients receiving transfusions from donors who developed a single spontaneous ICH in the Swedish or Danish cohort, nor for ischemic stroke as a negative control outcome.
"The current study is not yet a reason for alarm, certainly not a reason to avoid otherwise indicated blood transfusion, but it is a strong call for more scientific digging," Steven M. Greenberg, M.D., Ph.D., from Massachusetts General Hospital in Boston, writes in an accompanying editorial.
One author disclosed ties to the biopharmaceutical industry.
Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted September 2023
Read this next
Extreme Temperatures Linked to Increased Risk for Stroke Death
FRIDAY, May 24, 2024 -- Extreme cold and hot temperatures are associated with an increased risk for death from ischemic and hemorrhagic strokes, according to a study published...
Nationwide Prevalence of Stroke Up From 2011-2013 to 2020-2022
THURSDAY, May 23, 2024 -- The prevalence of stroke increased from 2011-2013 to 2020-2022, according to research published in the May 23 issue of the U.S. Centers for Disease...
Prehospital Reduction in BP Does Not Improve Stroke Outcomes
MONDAY, May 20, 2024 -- For patients with acute stroke, prehospital reduction in blood pressure does not affect functional outcomes, according to a study published online May 16...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.