Comparing Methadone vs Naloxone
Methadone | Naloxone |
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Methadone | Naloxone |
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Prescription only
Methadone is a potent opioid analgesic that may be used to relieve severe pain unresponsive to other strong pain relievers; however, it is more commonly used to treat opioid addiction. There is a... View more |
Prescription and OTC
Naloxone can be used by consumers and the lay-public, first-responders and healthcare providers to help reverse an overdose due to opioids (narcotics), including heroin and prescription opioids. It... View more |
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More about Methadone | More about Naloxone | ||||||||||||||||
Ratings & Reviews | |||||||||||||||||
Methadone has an average rating of 8.7 out of 10 from a total of 596 ratings on Drugs.com. 85% of reviewers reported a positive effect, while 5% reported a negative effect. |
Naloxone has an average rating of 7.9 out of 10 from a total of 26 ratings on Drugs.com. 75% of reviewers reported a positive effect, while 21% reported a negative effect. |
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Drug Class | |||||||||||||||||
Side Effects | |||||||||||||||||
See also: methadone side effects in more detail. |
See also: naloxone side effects in more detail. |
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Generic Availability | |||||||||||||||||
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all methadone prices |
View all naloxone prices |
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Dosage Form(s) Available | |||||||||||||||||
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Brand Names | |||||||||||||||||
Methadone Diskets, Methadose, Methadose Sugar-Free | Kloxxado, Narcan, Rextovy, Rezenopy, RiVive, Zimhi | ||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
30 hours |
3 hours |
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CSA Schedule ** View glossary of terms | |||||||||||||||||
High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||||||||||
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||||||||||
A total of 718 drugs are known to interact with methadone:
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A total of 30 drugs are known to interact with naloxone:
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Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions | |||||||||||||||||
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First Approval Date | |||||||||||||||||
August 13, 1947 |
April 13, 1971 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
N/A |
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More Information | |||||||||||||||||
Patient resources | |||||||||||||||||
Professional Resources | |||||||||||||||||
Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.