Aduhelm Alternatives Compared
Aduhelm | Leqembi | Donepezil |
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Aduhelm (aducanumab) | Leqembi (lecanemab) | Donepezil |
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Prescription only
Prescribed for Alzheimer's Disease. Aduhelm may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Alzheimer's Disease. Leqembi may also be used for purposes not listed in this medication guide. |
Prescription only
Donepezil boosts the effects of acetylcholine, a neurotransmitter that is noticeably depleted in people with Alzheimer's disease. Side effects are more likely at higher dosages and include nausea... View more |
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More about Aduhelm (aducanumab) | More about Leqembi (lecanemab) | More about Donepezil | ||||||||||||||||||||||||
Ratings & Reviews | ||||||||||||||||||||||||||
Be the first to share your experience with this drug. |
Be the first to share your experience with this drug. |
Donepezil has an average rating of 5.5 out of 10 from a total of 120 ratings on Drugs.com. 45% of reviewers reported a positive effect, while 38% reported a negative effect. |
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Drug Class | ||||||||||||||||||||||||||
Side Effects | ||||||||||||||||||||||||||
See also: Aduhelm side effects in more detail. |
See also: Leqembi side effects in more detail. |
See also: donepezil side effects in more detail. |
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Generic Availability | ||||||||||||||||||||||||||
N/A |
N/A |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Aduhelm prices |
View all Leqembi prices |
View all donepezil prices |
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Dosage Form(s) Available | ||||||||||||||||||||||||||
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Brand Names | ||||||||||||||||||||||||||
N/A |
N/A |
Adlarity, Aricept, Aricept ODT | ||||||||||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
909.6 hours |
168 hours |
70 hours |
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CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | ||||||||||||||||||||||||||
Summary unavailable. See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | ||||||||||||||||||||||||||
A total of 2 drugs are known to interact with Aduhelm:
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A total of 41 drugs are known to interact with Leqembi:
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A total of 476 drugs are known to interact with donepezil:
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Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions | ||||||||||||||||||||||||||
No known disease interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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First Approval Date | ||||||||||||||||||||||||||
June 07, 2021 |
January 06, 2023 |
November 25, 1996 |
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WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
N/A |
N/A |
N/A |
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More Information | ||||||||||||||||||||||||||
Patient resources | ||||||||||||||||||||||||||
Professional Resources | ||||||||||||||||||||||||||
Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.