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Active substance: PARACETAMOL

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This medicine is for the short term
treatment of acute moderate pain
when other painkillers have not
 You should only take this medicine
for a maximum of 3 days at a
time. If you need to take it for
longer than 3 days you should see
your doctor or pharmacist for
This medicine contains codeine which can cause addition if you take it
continuously for more than 3 days. This can give you withdrawal
symptoms from the medicine when you stop taking it.
If you take this medicine for headaches for more than 3 days it can make
them worse.

If you are under 12 years:
For pain relief in children and adolescents (0-18 years of age) after removal
of their tonsils or adenoids due to obstructive sleep apnoea syndrome
 If you know that you metabolise very rapidly codeine into morphine
 If you are breastfeeding.

1. What Solpadeine Plus Tablets do

Solpadeine Plus Tablets can be used in patients over 12 years of age for the
short-term relief of moderate pain that is not relieved by other
painkillers such as paracetamol or ibuprofen alone.
They can be used for migraine, headache, dental pain, period pain, backache
and rheumatic pain. The tablets contain three active ingredients; paracetamol,
codeine and caffeine. Codeine and paracetamol are both painkillers. Codeine
belongs to a group of medicines called opioid analgesics which act to relieve
pain. It can be used on its own or in combination with other painkillers.
Caffeine acts to further help the effectiveness of paracetamol.

2. Check before you take Solpadine Plus Tablets

Warnings and precautions
Codeine is transformed to morphine in the liver by an enzyme. Morphine is the
substance that produces pain relief. Some people have a variation of this enzyme
and this can affect people in different ways. In some people, morphine is not
produced or produced in very small quantities, and it will not provide enough
pain relief. Other people are more likely to get serious side effects because a very
high amount of morphine is produced. If you notice any of the following side
effects, you must stop taking this medicine and seek immediate medical advice:
slow or shallow breathing, confusion, sleepiness, small pupils, feeling or being
sick, constipation, lack of appetite.


Children and adolescents
Use in children and adolescents after surgery: Codeine should not be used for
pain relief in children and adolescents after removal of their tonsils or adenoids
due to Obstructive Sleep Apnoea Syndrome.
Use in children with breathing problems: Codeine is not recommended in
children with breathing problems, since the symptoms of morphine toxicity may
be worse in these children.
Talk to your doctor before taking Solpadeine Plus Tablets if you are
pregnant. Do not take Solpadeine Plus Tablets while you are breastfeeding.
Codeine and morphine passes into breast milk.

Difficulty in urinating.

Reporting of side effects: If you get any side effects, talk to your doctor,
pharmacist or nurse. This includes any possible side effects not listed in this
leaflet. You can also report side effects directly via the Yellow Card Scheme at:
By reporting side effects you can help provide more information on the safety
of this medicine.

Solpadeine Plus Tablets should not be taken by children below the
age of 12 years, due to the risk of severe breathing problems
This medicine should not be taken for more than 3 days. If the pain
does not improve after 3 days, talk to your doctor for advice.

Talk to a doctor at once if you take too much of this medicine, even if you feel
well. This is because too much paracetamol can cause delayed, serious liver damage.
If your symptoms continue or your headache becomes persistent, see your doctor.

This leaflet was last revised in November 2013.


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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.