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NITROMIN 400 MCG PER ACTUATION SUBLINGUAL SPRAY

Active substance: GLYCERYL TRINITRATE

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Read all of this leaflet carefully before you start using this medicine because
it contains important information for you.
– Keep this leaflet. You may need to read it again.
– If you have any further questions, ask your doctor or pharmacist.
– This medicine has been prescribed for you only. Do not pass it on to others.
It may harm them, even if their signs of illness are the same as yours.
– If you get any side effects, talk to your doctor or pharmacist. This includes
any possible side effects not listed in this leaflet. See section 4.
If this medicine does not work it may be an early
sign of a myocardial infarction (heart attack). If
this occurs, you should see your doctor
immediately or go to the casualty department.
Please tell your doctor or nurse that you are using
this medicine if you are having blood or urine
tests, as it may affect the results.
Children
The use of Nitromin Spray is not recommended
for children.
1. What Nitromin Spray is and what it is used
for
Other medicines and Nitromin Spray
Tell your doctor or pharmacist if you are taking,
Nitromin Spray is a smooth muscle relaxant. The
walls of many of the body’s veins and arteries are have recently taken or might take any other
made of smooth muscle, and so glyceryl trinitrate medicines.
helps to widen these vessels.
Never use Nitromin Spray with:
When you spray Nitromin Spray under your
Sildenafil, vardenafil or tadalafil containing
tongue it is quickly absorbed in the bloodstream.
erectile dysfunction preparations. The
The action of Nitromin Spray allows blood to flow
blood-pressure lowering effect of Nitromin Spray
more quickly and more easily. This means that
may be increased, possibly resulting in collapse,
your heart does not need to work so hard. The
unconsciousness and even death.
greater blood flow through the heart also means
Take care when using Nitromin Spray with:
that the heart works more efficiently. These
Medicines with blood pressure lowering effect,
actions of glyceryl trinitrate bring relief in an
such as vasodilators and other antihypertensive
attack of angina and can prevent an attack
agents, neuroleptics (used to treat mental
coming on.
illness), drugs used to treat depression (e.g.
Nitromin Spray is for the relief and prevention of
tricyclic antidepressants), sapropterin (used to
angina attacks (chest pains).
treat phenylketonuria) and N-acetylcysteine
(amino acid supplement). Any one of these
2. What you need to know before you use
medicines could increase the blood pressure
Nitromin Spray
lowering effect of glyceryl trinitrate.
Do not use Nitromin Spray if you:
Dihydroergotamine containing preparations for
Are allergic to glyceryl trinitrate, to other
the treatment of abnormal bleeding from the
nitrates, or any of the other ingredients of this
female reproductive system as the effect of this
medicine (listed in section 6) (you have
drug can be increased by glyceryl trinitrate.
previously had swelling of the face, extremities,
Heparin containing blood-thinning preparations
lips, inside of the mouth, tongue, glottis and/or
(the effectiveness of heparin may decrease).
larynx while using any of the nitrate
You may need a higher dose of glyceryl trinitrate if
preparations)
you have been previously treated with long-acting
Have marked hypotension (low blood pressure
nitrates (e.g. isosorbide dinitrate, isosorbide
with a systolic pressure below 90mmHg)
mononitrate).
Have too little circulating blood (due to blood
loss or dehydration)
If your doctor has prescribed tablets to be placed
Suffer from conditions where your heart is
under the tongue for your angina, you should not
unable to supply enough oxygenated blood to
use your spray for the same attack.
the rest of your body (cardiac shock or left
Nitromin Spray with alcohol
sided heart failure)
Consumption of alcoholic beverages during the
Have angina pectoris caused by hypertrophic,
use of the preparation is strictly forbidden as some
obstructive cardiomyopathy (abnormal heart
of the side effects may be worse than usual (see
growth)
section 4).
Have constrictive pericarditis (an inflammation
Pregnancy and breast-feeding
of the smooth membrane that surrounds the
If you are pregnant or breast-feeding, think you
heart)
may be pregnant or are planning to have a baby,
Have pericardial tamponade (an accumulation
ask your doctor or pharmacist for advice before
of fluid in the sac that surrounds the heart)
taking this medicine.
Have aortic and mitral stenosis (heart valve
Nitromin Spray should only be used in women
disease)
during pregnancy or breast-feeding, if the doctor
Suffer from primary pulmonary hypertension
considers that the benefit for the mother exceeds
(an increased resistance to blood flow through
any possible risk to the baby.
the lungs)
Have had a heart attack with low blood supply Driving and using machines
to the heart
It is not recommended to drive or use machinery
Are very anaemic
when you start using this product as the
Take sildenafil, tadalafil or vardenafil (these
hypotensive (blood pressure lowering) effect may
drugs are used for the treatment of male
lead to dizziness and/or feeling faint or unwell.
impotence)
After you have got used to the spray, it may be
Suffer from any condition with possible raised
that you have no problems and are able to drive
pressure within your head including that caused safely.
by an accident.
Nitromin Spray contains small amounts of
Warnings and precautions
ethanol (alcohol) and propylene glycol
Talk to your doctor or pharmacist before using
This product contains 79.2% volume of ethanol
Nitromin Spray.
(alcohol). Each dose (spray) contains up to 0.04 g of
If you are prone to postural hypotension (low
alcohol. This product may be harmful for patients
blood pressure) which can lead to dizziness
suffering from liver disease, alcoholism, epilepsy,
and/or fainting on sitting up or standing up
brain injury or disease.
If you suffer from narrow angle glaucoma
Propylene glycol may cause skin irritation.
(increased pressure in the eye), or migraine,
3. How to use Nitromin Spray
If you suffer from liver disease, alcoholism
epilepsy, cerebral trauma and other nervous
Always use this medicine exactly as your doctor or
system diseases (the spray contains small
pharmacist have told you. Check with your doctor
amounts of alcohol and may be harmful to
or pharmacist if you are not sure.
patients with the above conditions),
You may be given Nitromin Spray in either a
If you suffer from a disease of the blood vessels transparent plastic or aluminium canister.
supplying the brain (cerebrovascular disease),
If you have a transparent plastic canister follow
If you suffer from lung disease or lung disease
the instructions below to take off the cap:
related heart disease,
If you have a transparent plastic canister, when
If you had a recent heart attack (myocardial
using for the first time, you need to take off a shirt
infarction).
collar safety ring. (see Figure 1.)
If your dose is increased, you may become
tolerant to this medicine (where you need to use
higher doses to prevent or relieve the symptoms
Figure 1. – Taking off shirt
of an angina attack) or to other medicines
collar safety ring
containing nitrates.
What is in this leaflet:
1. What Nitromin sublingual spray (henceforth
Nitromin Spray) is and what it is used for
2. What you need to know before you use
Nitromin Spray
3. How to use Nitromin Spray
4. Possible side effects
5. How to store Nitromin Spray
6. Contents of the pack and other information
























PACKAGE LEAFLET: INFORMATION FOR THE USER



Active substance: glyceryl trinitrate

Nitromin Sublingual Spray







Continued top of the next column

Continued over page






Like all medicines, this medicine can cause side
effects, although not everybody gets them.
Very common (affects more than 1 user in 10)
Headache.
Common (affects 1 to 10 users in 100)
Dizziness
Drowsiness
Fast heart beat
Decreased blood pressure*
Fall of blood pressure when standing up or
sitting up*
Weakness.
Uncommon (affects 1 to 10 users in 1,000)
Syncope (loss of consciousness)
Worsened angina pectoris symptoms (increase
of chest pain)
Slow heart beat
Cyanosis (blue or purple coloration of the skin
or mucous membranes due to the tissues near
the skin surface being low on oxygen)
Facial flushing
Circulatory collapse (failure of the blood
circulation)
Nausea (feeling sick)
Vomiting (being sick).

















w/w (400 micrograms per spray).
The other ingredients are ethanol and propylene
glycol.
What Nitromin Spray looks like and contents
of the pack
The aluminium or transparent plastic canister is
equipped with a metered dose valve and a
protective cap. Each canister containing 10g of
solution is designed to deliver at least 180 doses.
Marketing Authorisation Holder
EGIS Pharmaceuticals UK Ltd.
127 Shirland Road
London
W9 2EP
United Kingdom
Manufacturer
EGIS Pharmaceuticals PLC
Mátyás Király út 65.
Körmend
H-9900
Hungary
This leaflet was last revised in September 2014
Article No.

4. Possible side effects

84262-D
Continued top of the next column

P

This leaflet was
last revised in
September 2014

Nitromin Sublingual Spray









Active substance: glyceryl trinitrate



PACKAGE LEAFLET: INFORMATION FOR THE USER

Very rare (affects less than 1 user in 10,000)
Methaemoglobinemia (a disorder characterized
by the presence of a higher than normal level of
methemoglobin in the blood. This leads to an
overall reduced ability of the red blood cell to
release oxygen to tissues).
Figure 2. – Snapping off
Restlessness
the cap
Decreased blood flow to the brain
Heartburn
Bad breath
Difficulty breathing
Exfoliative dermatitis (itchy, scaling skin rash)
Skin rash.
If you have an aluminium canister follow the
instruction below to take off the cap:
* Particularly upon initiation of therapy and
When using the aluminium canister, you can
following an increase in dose.
easily snap the cap off. (see Figure 3.)
The following side effects may also occur in
approximately 30-40% of patients: taste
disturbance (metallic taste), mild burning or
Figure 3. – Snapping off
the cap without shirt collar stinging sensation in the mouth or tongue, and
palpitations (feeling your heartbeat). These are
safety ring from the
usually mild and disappear within a few minutes.
aluminium canister
Some people are more sensitive to the effects of
glyceryl trinitrate than others.
Rarely allergic skin reactions or in some cases
hypersensitivity reactions and exfoliative
Before using the spray for the first time, check
dermatitis (itchy, scaling skin rash) may appear.
that the pump is working by pressing the pump
If you experience any of these, stop using the
button a few times until it produces a fine mist of
spray and consult your doctor immediately.
liquid. Practice aiming the spray onto a tissue or
Headache may occur at the beginning of the
similar item so that you will be able to aim it
treatment. The first dose, or the first higher
correctly under the tongue when you need to use
dose, may cause a blood pressure drop and/or
it. If you do not need to use the spray very often,
postural hypotension (fainting or feeling faint
remember to check the pump regularly to see that
when standing up or getting out of bed),
it still works properly.
tachycardia (your heart may seem to speed
If possible, sit down before using your spray. Rest
up), dizziness and weakness.
or sit quietly, as you may feel faint or dizzy
In cases where there is a large fall in blood
otherwise, particularly if you are elderly. Take off
pressure, this medicine may make the
the plastic cap and hold the spray bottle upright.
symptoms of angina worse.
There is no need to shake the canister before
Sometimes the heart rate may slow and even lead
dosing.
to feeling faint or actually fainting.
The spray outlet should then be placed close to
Usually these are mild and will stop after a few
the mouth. Hold your breath for a moment to
minutes.
avoid breathing in the spray, then open your
mouth and spray a dose under your tongue by
Reporting of side effects
pressing down on the pump button then letting
If you get any side effects, talk to your doctor or
go. The mouth should be closed immediately after pharmacist. This includes any possible side effects
each dose (spray). The spray should not be
not listed in this leaflet. You can also report side
breathed in.
effects directly via the Yellow Card Scheme
It is useful to become aware of the position of the (Website: www.mhra.gov.uk/yellowcard). By
spray outlet so that its using at night can be easily reporting side effects you can help provide more
achieved.
information on the safety of this medicine.
At the onset of an attack use one or two doses
5. How to store Glyceryl Trinitrate Spray
(sprays) under your tongue, and then immediately
Store below 25°C, in the original package in order
close your mouth before breathing normally
to protect from light.
through your nose again.
Keep this medicine out of the sight and reach
If symptoms do not resolve, this dose may be
of children.
repeated at five minute intervals for a total of
Do not use this medicine after the expiry date
three doses (sprays).
which is stated on the carton and on the base of
If symptoms have not resolved after a total of
the aluminium canister or on the label of plastic
three doses (sprays), seek prompt medical
canister.
attention.
Do not store above 25°C (normal room
For the prevention of an attack use one or two
temperature).
doses (sprays) immediately before the event.
Protect from sunlight.
Put the cap back on the spray bottle.
Do not use it near to anyone that is smoking; or
spray the product into a naked flame or onto a
If you are not sure how to use the spray, ask your
hot surface.
pharmacist to show you.
Do not pierce or burn the canister after use.
If you use more Nitromin Spray than you
Do not throw away any medicines via wastewater
should
or household waste. Ask your pharmacist how to
If you use too many sprays some of the side
throw away medicines you no longer use. These
effects (see below) may be worse than usual.
measures will help to protect the environment.
In this case you should see your doctor
immediately.
6. Contents of the pack and other information
If you have any further questions on the use of
What Nitromin Spray contains
this medicine, ask your doctor or pharmacist.
The active substance is glyceryl trinitrate 0.8%
Then taking the transparent plastic canister in one
hand, you can easily snap the cap off sideways
with the other hand. (see Figure 2.)

Read all of this leaflet carefully before you start using this medicine because
it contains important information for you.
– Keep this leaflet. You may need to read it again.
– If you have any further questions, ask your doctor or pharmacist.
– This medicine has been prescribed for you only. Do not pass it on to others.
It may harm them, even if their signs of illness are the same as yours.
– If you get any side effects, talk to your doctor or pharmacist. This includes
any possible side effects not listed in this leaflet. See section 4.
If this medicine does not work it may be an early
sign of a myocardial infarction (heart attack). If
this occurs, you should see your doctor
immediately or go to the casualty department.
Please tell your doctor or nurse that you are using
this medicine if you are having blood or urine
tests, as it may affect the results.
Children
The use of Nitromin Spray is not recommended
for children.
1. What Nitromin Spray is and what it is used
for
Other medicines and Nitromin Spray
Tell your doctor or pharmacist if you are taking,
Nitromin Spray is a smooth muscle relaxant. The
walls of many of the body’s veins and arteries are have recently taken or might take any other
made of smooth muscle, and so glyceryl trinitrate medicines.
helps to widen these vessels.
Never use Nitromin Spray with:
When you spray Nitromin Spray under your
Sildenafil, vardenafil or tadalafil containing
tongue it is quickly absorbed in the bloodstream.
erectile dysfunction preparations. The
The action of Nitromin Spray allows blood to flow
blood-pressure lowering effect of Nitromin Spray
more quickly and more easily. This means that
may be increased, possibly resulting in collapse,
your heart does not need to work so hard. The
unconsciousness and even death.
greater blood flow through the heart also means
Take care when using Nitromin Spray with:
that the heart works more efficiently. These
Medicines with blood pressure lowering effect,
actions of glyceryl trinitrate bring relief in an
such as vasodilators and other antihypertensive
attack of angina and can prevent an attack
agents, neuroleptics (used to treat mental
coming on.
illness), drugs used to treat depression (e.g.
Nitromin Spray is for the relief and prevention of
tricyclic antidepressants), sapropterin (used to
angina attacks (chest pains).
treat phenylketonuria) and N-acetylcysteine
(amino acid supplement). Any one of these
2. What you need to know before you use
medicines could increase the blood pressure
Nitromin Spray
lowering effect of glyceryl trinitrate.
Do not use Nitromin Spray if you:
Dihydroergotamine containing preparations for
Are allergic to glyceryl trinitrate, to other
the treatment of abnormal bleeding from the
nitrates, or any of the other ingredients of this
female reproductive system as the effect of this
medicine (listed in section 6) (you have
drug can be increased by glyceryl trinitrate.
previously had swelling of the face, extremities,
Heparin containing blood-thinning preparations
lips, inside of the mouth, tongue, glottis and/or
(the effectiveness of heparin may decrease).
larynx while using any of the nitrate
You may need a higher dose of glyceryl trinitrate if
preparations)
you have been previously treated with long-acting
Have marked hypotension (low blood pressure
nitrates (e.g. isosorbide dinitrate, isosorbide
with a systolic pressure below 90mmHg)
mononitrate).
Have too little circulating blood (due to blood
loss or dehydration)
If your doctor has prescribed tablets to be placed
Suffer from conditions where your heart is
under the tongue for your angina, you should not
unable to supply enough oxygenated blood to
use your spray for the same attack.
the rest of your body (cardiac shock or left
Nitromin Spray with alcohol
sided heart failure)
Consumption of alcoholic beverages during the
Have angina pectoris caused by hypertrophic,
use of the preparation is strictly forbidden as some
obstructive cardiomyopathy (abnormal heart
of the side effects may be worse than usual (see
growth)
section 4).
Have constrictive pericarditis (an inflammation
Pregnancy and breast-feeding
of the smooth membrane that surrounds the
If you are pregnant or breast-feeding, think you
heart)
may be pregnant or are planning to have a baby,
Have pericardial tamponade (an accumulation
ask your doctor or pharmacist for advice before
of fluid in the sac that surrounds the heart)
taking this medicine.
Have aortic and mitral stenosis (heart valve
Nitromin Spray should only be used in women
disease)
during pregnancy or breast-feeding, if the doctor
Suffer from primary pulmonary hypertension
considers that the benefit for the mother exceeds
(an increased resistance to blood flow through
any possible risk to the baby.
the lungs)
Have had a heart attack with low blood supply Driving and using machines
to the heart
It is not recommended to drive or use machinery
Are very anaemic
when you start using this product as the
Take sildenafil, tadalafil or vardenafil (these
hypotensive (blood pressure lowering) effect may
drugs are used for the treatment of male
lead to dizziness and/or feeling faint or unwell.
impotence)
After you have got used to the spray, it may be
Suffer from any condition with possible raised
that you have no problems and are able to drive
pressure within your head including that caused safely.
by an accident.
Nitromin Spray contains small amounts of
Warnings and precautions
ethanol (alcohol) and propylene glycol
Talk to your doctor or pharmacist before using
This product contains 79.2% volume of ethanol
Nitromin Spray.
(alcohol). Each dose (spray) contains up to 0.04 g of
If you are prone to postural hypotension (low
alcohol. This product may be harmful for patients
blood pressure) which can lead to dizziness
suffering from liver disease, alcoholism, epilepsy,
and/or fainting on sitting up or standing up
brain injury or disease.
If you suffer from narrow angle glaucoma
Propylene glycol may cause skin irritation.
(increased pressure in the eye), or migraine,
3. How to use Nitromin Spray
If you suffer from liver disease, alcoholism,
epilepsy, cerebral trauma and other nervous
Always use this medicine exactly as your doctor or
system diseases (the spray contains small
pharmacist have told you. Check with your doctor
amounts of alcohol and may be harmful to
or pharmacist if you are not sure.
patients with the above conditions),
You may be given Nitromin Spray in either a
If you suffer from a disease of the blood vessels transparent plastic or aluminium canister.
supplying the brain (cerebrovascular disease),
If you have a transparent plastic canister follow
If you suffer from lung disease or lung disease
the instructions below to take off the cap:
related heart disease,
If you have a transparent plastic canister, when
If you had a recent heart attack (myocardial
using for the first time, you need to take off a shirt
infarction).
collar safety ring. (see Figure 1.)
If your dose is increased, you may become
tolerant to this medicine (where you need to use
higher doses to prevent or relieve the symptoms
Figure 1. – Taking off shirt
of an angina attack) or to other medicines
collar safety ring
containing nitrates.
What is in this leaflet:
1. What Nitromin sublingual spray (henceforth
Nitromin Spray) is and what it is used for
2. What you need to know before you use
Nitromin Spray
3. How to use Nitromin Spray
4. Possible side effects
5. How to store Nitromin Spray
6. Contents of the pack and other information
























PACKAGE LEAFLET: INFORMATION FOR THE USER



Active substance: glyceryl trinitrate

Nitromin Sublingual Spray







Continued top of the next column

Continued over page


















Article No.






87009-B

Continued top of the next column

P

This leaflet was
last revised in
September 2014

Nitromin Sublingual Spray









Active substance: glyceryl trinitrate



PACKAGE LEAFLET: INFORMATION FOR THE USER

Very rare (affects less than 1 user in 10,000)
Methaemoglobinemia (a disorder characterized
by the presence of a higher than normal level of
methemoglobin in the blood. This leads to an
overall reduced ability of the red blood cell to
release oxygen to tissues).
Figure 2. – Snapping off
Restlessness
the cap
Decreased blood flow to the brain
Heartburn
Bad breath
Difficulty breathing
Exfoliative dermatitis (itchy, scaling skin rash)
Skin rash.
If you have an aluminium canister follow the
instruction below to take off the cap:
* Particularly upon initiation of therapy and
When using the aluminium canister, you can
following an increase in dose.
easily snap the cap off. (see Figure 3.)
The following side effects may also occur in
approximately 30-40% of patients: taste
disturbance (metallic taste), mild burning or
Figure 3. – Snapping off
the cap without shirt collar stinging sensation in the mouth or tongue, and
palpitations (feeling your heartbeat). These are
safety ring from the
usually mild and disappear within a few minutes.
aluminium canister
Some people are more sensitive to the effects of
glyceryl trinitrate than others.
Rarely allergic skin reactions or in some cases
hypersensitivity reactions and exfoliative
Before using the spray for the first time, check
dermatitis (itchy, scaling skin rash) may appear.
that the pump is working by pressing the pump
If you experience any of these, stop using the
button a few times until it produces a fine mist of
spray and consult your doctor immediately.
liquid. Practice aiming the spray onto a tissue or
Headache may occur at the beginning of the
similar item so that you will be able to aim it
treatment. The first dose, or the first higher
correctly under the tongue when you need to use
dose, may cause a blood pressure drop and/or
it. If you do not need to use the spray very often,
postural hypotension (fainting or feeling faint
remember to check the pump regularly to see that
when standing up or getting out of bed),
it still works properly.
tachycardia (your heart may seem to speed
If possible, sit down before using your spray. Rest
up), dizziness and weakness.
or sit quietly, as you may feel faint or dizzy
In cases where there is a large fall in blood
otherwise, particularly if you are elderly. Take off
pressure, this medicine may make the
the plastic cap and hold the spray bottle upright.
symptoms of angina worse.
There is no need to shake the canister before
Sometimes the heart rate may slow and even lead
dosing.
to feeling faint or actually fainting.
The spray outlet should then be placed close to
Usually these are mild and will stop after a few
the mouth. Hold your breath for a moment to
minutes.
avoid breathing in the spray, then open your
mouth and spray a dose under your tongue by
Reporting of side effects
pressing down on the pump button then letting
If you get any side effects, talk to your doctor or
go. The mouth should be closed immediately after pharmacist. This includes any possible side effects
each dose (spray). The spray should not be
not listed in this leaflet. You can also report side
breathed in.
effects directly via the Yellow Card Scheme
It is useful to become aware of the position of the (Website: www.mhra.gov.uk/yellowcard). By
spray outlet so that its using at night can be easily reporting side effects you can help provide more
achieved.
information on the safety of this medicine.
At the onset of an attack use one or two doses
(sprays) under your tongue, and then immediately 5. How to store Glyceryl Trinitrate Spray
Store below 25°C, in the original package in order
close your mouth before breathing normally
to protect from light.
through your nose again.
Keep this medicine out of the sight and reach
If symptoms do not resolve, this dose may be
of children.
repeated at five minute intervals for a total of
Do not use this medicine after the expiry date
three doses (sprays).
which is stated on the carton and on the base of
If symptoms have not resolved after a total of
the aluminium canister or on the label of plastic
three doses (sprays), seek prompt medical
canister.
attention.
Do not store above 25°C (normal room
For the prevention of an attack use one or two
temperature).
doses (sprays) immediately before the event.
Protect from sunlight.
Put the cap back on the spray bottle.
Do not use it near to anyone that is smoking; or
spray the product into a naked flame or onto a
If you are not sure how to use the spray, ask your
hot surface.
pharmacist to show you.
Do not pierce or burn the canister after use.
If you use more Nitromin Spray than you
Do not throw away any medicines via wastewater
should
or household waste. Ask your pharmacist how to
If you use too many sprays some of the side
throw away medicines you no longer use. These
effects (see below) may be worse than usual.
measures will help to protect the environment.
In this case you should see your doctor
immediately.
6. Contents of the pack and other information
If you have any further questions on the use of
What Nitromin Spray contains
this medicine, ask your doctor or pharmacist.
The active substance is glyceryl trinitrate 0.8%
w/w (400 micrograms per spray).
4. Possible side effects
The other ingredients are ethanol and propylene
Like all medicines, this medicine can cause side
glycol.
effects, although not everybody gets them.
What Nitromin Spray looks like and contents
Very common (affects more than 1 user in 10)
of the pack
Headache.
The aluminium or transparent plastic canister is
equipped with a metered dose valve and a
Common (affects 1 to 10 users in 100)
protective cap. Each canister containing 11g of
Dizziness
solution is designed to deliver at least 200 doses.
Drowsiness
Fast heart beat
Marketing Authorisation Holder
Decreased blood pressure*
EGIS Pharmaceuticals UK Ltd.
Fall of blood pressure when standing up or
127 Shirland Road
sitting up*
London
Weakness.
W9 2EP
United Kingdom
Uncommon (affects 1 to 10 users in 1,000)
Manufacturer
Syncope (loss of consciousness)
EGIS Pharmaceuticals PLC
Worsened angina pectoris symptoms (increase
Mátyás Király út 65.
of chest pain)
Körmend
Slow heart beat
H-9900
Cyanosis (blue or purple coloration of the skin
Hungary
or mucous membranes due to the tissues near
the skin surface being low on oxygen)
This leaflet was last revised in September 2014
Facial flushing
Circulatory collapse (failure of the blood
circulation)
Nausea (feeling sick)
Vomiting (being sick).
Then taking the transparent plastic canister in one
hand, you can easily snap the cap off sideways
with the other hand. (see Figure 2.)

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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