Zynlonta Side Effects

Generic name: loncastuximab tesirine

Medically reviewed by Drugs.com. Last updated on Mar 9, 2024.

Note: This document contains side effect information about loncastuximab tesirine. Some dosage forms listed on this page may not apply to the brand name Zynlonta.

Applies to loncastuximab tesirine: intravenous powder for solution.

Serious side effects of Zynlonta

Along with its needed effects, loncastuximab tesirine (the active ingredient contained in Zynlonta) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking loncastuximab tesirine:

More common

Black, tarry stools
bleeding gums
blood in the urine or stools
body aches or pain
chills
cough
ear congestion
fever
headache
increased sensitivity of the skin to sunlight
itching, skin rash
loss of voice
lower back or side pain
muscle or bone pain
pain or tenderness around the eyes and cheekbones
painful or difficult urination
pale skin
pinpoint red spots on the skin
redness or other discoloration of the skin
severe sunburn
sore throat
stuffy or runny nose
swelling of the hands, ankles, feet, or lower legs
swelling or puffiness of the face
tightness in the chest
trouble breathing
ulcers, sores, or white spots in the mouth
unusual bleeding or bruising
unusual tiredness or weakness

Less common

Anxiety
blistering, crusting, irritation, itching, or reddening of the skin
blue or pale skin
chest pain, possibly moving to the left arm, neck, or shoulder
confusion
cracked, dry, scaly skin
darkening of the skin
dizziness
dry cough
fainting
fast heartbeat
general feeling of discomfort or illness
lightheadedness
rapid, shallow breathing
sneezing
thickening of bronchial secretions

Other side effects of Zynlonta

Some side effects of loncastuximab tesirine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Back pain
constipation
decreased appetite
diarrhea
difficulty in moving
joint pain
lack or loss of strength
muscle aches, cramps, or stiffness
nausea
stomach pain
swollen joints
unusual drowsiness, dullness, or feeling of sluggishness
vomiting

For Healthcare Professionals

Applies to loncastuximab tesirine: intravenous injection.

Hematologic

Very common (10% or more): Platelets decreased (58%), neutrophils decreased (52%), hemoglobin decreased (51%), albumin decreased (37%), neutropenia (Grade 3 or 4) (32%), thrombocytopenia (20%), anemia (12%)

Common (1% to 10%): Febrile neutropenia^[Ref]

Immunologic

Common (1% to 10%): Sepsis/escherichia sepsis/septic shock

Frequency not reported: Immunogenicity^[Ref]

Local

Uncommon (0.1% to 1%): Infusion site extravasation^[Ref]

Musculoskeletal

Very common (10% or more): Musculoskeletal pain (e.g., musculoskeletal pain, musculoskeletal chest pain, musculoskeletal discomfort, back pain, limb discomfort, myalgia, neck pain, non-cardiac chest pain, pain in extremity) (23%)^[Ref]

Metabolic

Very common (10% or more): Glucose increased (48%), edema (e.g., edema, face edema, generalized edema, peripheral edema, ascites, fluid overload, peripheral swelling, swelling, swelling face) (28%), anorexia (15%)^[Ref]

Hepatic

Very common (10% or more): AST increased (37%), ALT increased (34%)^[Ref]

Respiratory

Very common (10% or more): Dyspnea/dyspnea exertional (13%), pleural effusion (10%), upper respiratory tract infection (e.g., upper respiratory tract infection, upper respiratory tract congestion, nasopharyngitis, rhinitis, rhinovirus infection, sinusitis (10%)

Common (1% to 10%): Pleural effusion (Grade 3), pneumonia/pneumonitis, pleuritis^[Ref]

Other

Very common (10% or more): Fatigue/asthenia/lethargy (38%)^[Ref]

General

The most common (greater than 20%) adverse reactions, including laboratory abnormalities, were thrombocytopenia, increased gamma-glutamyltransferase, neutropenia, anemia, hyperglycemia, transaminase elevation, fatigue, hypoalbuminemia, rash, edema, nausea, and musculoskeletal pain.^[Ref]

Cardiovascular

Common (1% to 10%): Pericarditis^[Ref]

Dermatologic

Very common (10% or more): Rash (e.g., rash erythematous, rash maculopapular, rash pruritic, rash pustular, erythema, generalized erythema, dermatitis, dermatitis acneiform, dermatitis bullous, dermatitis exfoliative generalized, palmar-plantar erythrodysesthesia syndrome) (30%), pruritus (12%), photosensitivity reaction (10%)

Common (1% to 10%): Hyperpigmentation, dermatitis^[Ref]

Gastrointestinal

Very common (10% or more): Nausea (23%), diarrhea (17%), abdominal pain (e.g., abdominal pain, abdominal discomfort, abdominal pain lower, abdominal pain upper) (14%), vomiting (13%), constipation (12%)

Common (1% to 10%): Pericardial effusion^[Ref]