Xigris Side Effects

Generic Name: drotrecogin alfa

Note: This page contains side effects data for the generic drug drotrecogin alfa. It is possible that some of the dosage forms included below may not apply to the brand name Xigris.

It is possible that some side effects of Xigris may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to drotrecogin alfa: intravenous powder for solution

As well as its needed effects, drotrecogin alfa (the active ingredient contained in Xigris) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking drotrecogin alfa, check with your doctor or nurse immediately:

More common
  • Bleeding

For Healthcare Professionals

Applies to drotrecogin alfa: intravenous powder for injection

General

The most common side effect associated with drotrecogin alfa (the active ingredient contained in Xigris) has been bleeding.

Hematologic

Hematologic side effects have most commonly included bleeding (25% vs 18% with placebo). The majority of events were ecchymoses or gastrointestinal tract bleeding. Serious bleeding has been reported in 3.5% of patients (vs 2% with placebo) and included intracranial hemorrhage, life threatening hemorrhage, and any event requiring 3 or more units of packed red blood cells per days for 2 consecutive days.

Serious bleeding events have been reported at the following sites: Gastrointestinal, intra-abdominal, intrathoracic, retroperitoneal, intracranial, genitourinary, skin or soft tissues.

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