Voraxaze Side Effects

Generic Name: glucarpidase

Note: This document contains side effect information about glucarpidase. Some of the dosage forms listed on this page may not apply to the brand name Voraxaze.

Some side effects of Voraxaze may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to glucarpidase: intravenous powder for solution

Along with its needed effects, glucarpidase (the active ingredient contained in Voraxaze) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking glucarpidase:

Less common
  • Blurred vision
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • sweating
  • unusual tiredness or weakness
Rare
  • Cough
  • difficulty with swallowing
  • dizziness
  • fever
  • headache
  • hives
  • hoarseness
  • irritation
  • itching
  • joint pain, stiffness, or swelling
  • nervousness
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash
  • redness of the skin
  • shortness of breath
  • slow or fast heartbeat
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • wheezing

Some side effects of glucarpidase may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • feeling of warmth
  • nausea
  • redness of the face, neck, arms, and occasionally, upper chest
  • vomiting
Rare
  • Diarrhea
  • shakiness in the legs, arms, hands, or feet
  • sore throat
  • trembling or shaking of the hands or feet

For Healthcare Professionals

Applies to glucarpidase: intravenous powder for injection

Cardiovascular

Cardiovascular side effects have included flushing (2%), hypotension (1%), and hypertension (less than 1%).

Dermatologic

Dermatologic side effects have included rash (less than 1%).

Gastrointestinal

Gastrointestinal side effects have included nausea and vomiting (2%), diarrhea (less than 1%) and throat irritation/tightness (less than 1%).

Hypersensitivity

Hypersensitivity reactions have included hypersensitivity reaction (less than 1%) including anaphylaxis.

Nervous system

Nervous system side effects have included paraesthesias (2%), headache (1%), and tremor (less than 1%).

Ocular

Ocular side effects have included blurred vision (less than 1%).

Immunologic

Immunologic side effects have included the development of anti-glucarpidase (the active ingredient contained in Voraxaze) antibodies (21%).

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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