Voraxaze Side Effects

Generic name: glucarpidase

Note: This document contains side effect information about glucarpidase. Some of the dosage forms listed on this page may not apply to the brand name Voraxaze.

Some side effects of Voraxaze may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to glucarpidase: intravenous powder for injection

Get emergency medical help if you have any of these signs of an allergic reaction while taking glucarpidase (the active ingredient contained in Voraxaze) hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some people receiving a glucarpidase injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you have:

• severe dizziness or weakness;

• severe nausea, feeling like you might pass out;

• cold sweat, itching, numbness or tingly feeling;

• sudden headache;

• fast heartbeats, chest tightness; or

• trouble breathing.

Less serious side effects of glucarpidase may include:

• mild nausea;

• mild headache; or

• mild numbness or tingling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to glucarpidase: intravenous powder for injection

Cardiovascular

Cardiovascular side effects have included flushing (2%), hypotension (1%), and hypertension (less than 1%).

Dermatologic

Dermatologic side effects have included rash (less than 1%).

Gastrointestinal

Gastrointestinal side effects have included nausea and vomiting (2%), diarrhea (less than 1%) and throat irritation/tightness (less than 1%).

Hypersensitivity

Hypersensitivity reactions have included hypersensitivity reaction (less than 1%) including anaphylaxis.

Nervous system

Nervous system side effects have included paraesthesias (2%), headache (1%), and tremor (less than 1%).

Ocular

Ocular side effects have included blurred vision (less than 1%).

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