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Vitamin K Side Effects

Generic Name: phytonadione

Note: This page contains side effects data for the generic drug phytonadione. It is possible that some of the dosage forms included below may not apply to the brand name Vitamin K.

It is possible that some side effects of Vitamin K may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to phytonadione: capsule, tablet

As well as its needed effects, phytonadione (the active ingredient contained in Vitamin K) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking phytonadione, check with your doctor or nurse as soon as possible:

Less common - With menadiol or high doses of phytonadione in newborns
  • Decreased appetite
  • decreased movement or activity
  • difficulty in breathing
  • enlarged liver
  • general body swelling
  • irritability
  • muscle stiffness
  • paleness
  • yellow eyes or skin
Rare - With injection only
  • Difficulty in swallowing
  • fast or irregular breathing
  • lightheadedness or fainting
  • shortness of breath
  • skin rash, hives and/or itching
  • swelling of eyelids, face, or lips
  • tightness in chest
  • troubled breathing and/or wheezing
Rare
  • Blue color or flushing or redness of skin
  • dizziness
  • fast and/or weak heartbeat
  • increased sweating
  • low blood pressure (temporary)

Some phytonadione side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common
  • Flushing of face
  • redness, pain, or swelling at place of injection
  • skin lesions at place of injection (rare)
  • unusual taste

For Healthcare Professionals

Applies to phytonadione: compounding powder, injectable solution, oral tablet

Local

Rare (less than 0.1%): Injection site reactions (inflammation, atrophy, necrosis)
Very rare (less than 0.01%): Venous irritation or phlebitis (IV route)
Frequency not reported: Pain, swelling, and tenderness at the injection site[Ref]

Cardiovascular

Rare (less than 0.1%): Rapid and weak pulse, brief hypotension, cyanosis
Very rare (less than 0.01%): Facial flushing[Ref]

Hypersensitivity

Very rare (less than 0.01%): Anaphylactoid reactions (IV route)
Frequency not reported: Allergic sensitivity, anaphylaxis[Ref]

Fatalities and other severe reactions have occurred during or immediately after the parenteral administration of phytonadione. The majority of these reactions have occurred with intravenous administration. These reactions resemble hypersensitivity or anaphylaxis and include shock and cardiac or respiratory arrest. Feelings of uneasiness, flushing, diaphoresis, chest pain, tachycardia, cyanosis, weakness, and dyspnea may precede the cardiopulmonary event. These severe reactions are more likely with, but are not limited to, rapid infusions of undiluted drug.[Ref]

Gastrointestinal

Gastrointestinal side effects have rarely included 'peculiar' sensations of taste.

Respiratory

Rare (less than 0.1%): Dyspnea[Ref]

Other

Frequency not reported: Death (IV and IM routes)[Ref]

Dermatologic

Uncommon (0.1% to 1%): Erythematous, indurated, pruritic plaques
Rare (less than 0.1%): Profuse sweating, scleroderma-like lesions,
Very rare (less than 0.01%): Sweating
Frequency not reported: Erythema perstans-like lesions[Ref]

Nervous system

Rare (less than 0.1%): Dizziness
Very rare (less than 0.01%): Unusual taste[Ref]

Hepatic

Hyperbilirubinemia occurred primarily with doses above those recommended.[Ref]

Rare (less than 0.1%): Hyperbilirubinemia in newborns
Frequency not reported: Jaundice in newborns[Ref]

Hematologic

Frequency not reported: Hemolysis in newborns[Ref]

General

The most common adverse events were dermatologic and injection site reactions.[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Vitamin K Injection (phytonadione)." Abbott Pharmaceutical, Abbott Park, IL.

4. "Product Information. Mephyton (phytonadione)." Merck & Co, Inc, West Point, PA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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