Tazverik Side Effects

Generic name: tazemetostat

Medically reviewed by Drugs.com. Last updated on Jan 19, 2024.

Note: This document contains side effect information about tazemetostat. Some dosage forms listed on this page may not apply to the brand name Tazverik.

Applies to tazemetostat: oral tablet.

Serious side effects of Tazverik

Along with its needed effects, tazemetostat (the active ingredient contained in Tazverik) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tazemetostat:

More common

Bladder pain
bleeding gums
bloody or cloudy urine
body aches or pain
chest pain or tightness
cough
coughing up blood
difficult, burning, or painful urination
difficulty in breathing or swallowing
dizziness
ear congestion
fever or chills
frequent urge to urinate
headache
increased menstrual flow or vaginal bleeding
loss of voice
lower back or side pain
muscle or bone pain
nosebleeds
pale skin
prolonged bleeding from cuts
red or black, tarry stools
red or dark brown urine
redness, itching, pain, swelling, tenderness, or warmth on the skin
sneezing
sore throat
stuffy or runny nose
unusual bleeding or bruising
unusual tiredness or weakness

Less common

Confusion
fast heartbeat
lightheadedness or fainting
painful blisters on the trunk of the body
rapid, shallow breathing

Rare

General feeling of illness
hoarseness
sores, ulcers, or white spots on the lips or in the mouth
swollen glands
weight loss
yellow skin and eyes

Other side effects of Tazverik

Some side effects of tazemetostat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Constipation
decreased appetite
diarrhea
hair loss or thinning
nausea or vomiting
skin rash
stomach pain

For Healthcare Professionals

Applies to tazemetostat: oral tablet.

General

The most common adverse reactions (20% or greater) were pain, musculoskeletal pain, abdominal pain, fatigue, nausea, decreased appetite, vomiting, upper respiratory tract infection, and constipation.^[Ref]

Dermatologic

Very common (10% or more): Alopecia (17%), rash (15%)

Common (1% to 10%): Herpes zoster^[Ref]

Gastrointestinal

Very common (10% or more): Nausea (36%), vomiting (24%), constipation (21%), diarrhea (16%), abdominal pain (e.g., abdominal discomfort, abdominal pain, abdominal pain lower, abdominal pain upper) (13%)^[Ref]

Genitourinary

Very common (10% or more): Urinary tract infection (e.g., cystitis, urinary tract infection, urinary tract infection staphylococcal) (11%)^[Ref]

Hematologic

Very common (10% or more): Hemoglobin decreased (49%), decreased lymphocytes (36%), white blood cell count decreased (19%), hemorrhage (e.g., wound hemorrhage, rectal hemorrhage, pulmonary hemorrhage, hemorrhage intracranial, cerebral hemorrhage, hemoptysis) (18%), anemia (16%), partial thromboplastin time increased (15%)^[Ref]

Hepatic

Very common (10% or more): Aspartate aminotransferase increased (18%), alanine aminotransferase increased (14%)^[Ref]

Metabolic

Very common (10% or more): Triglycerides increased (36%), glucose increased (33%), sodium decreased (30%), phosphate decreased (28%), anorexia (26%), albumin decreased (23%), alkaline phosphatase increased (23%), potassium decreased (20%), weight loss (16%), calcium decreased (16%), glucose decreased (16%), potassium increased (12%), decreased appetite (26%)^[Ref]

Musculoskeletal

Very common (10% or more): Musculoskeletal pain (e.g., back pain, limb discomfort, musculoskeletal chest pain, musculoskeletal discomfort, musculoskeletal pain, myalgia, neck pain, non-cardiac chest pain, pain in extremity, pain in jaw, spinal pain) (22%)^[Ref]

Nervous system

Very common (10% or more): Headache (e.g., headache, migraine, sinus headache) (18%)^[Ref]

Oncologic

Uncommon (0.1% to 1%): Secondary malignancies (e.g., myelodysplastic syndrome [MDS], acute myeloid leukemia [AML])^[Ref]

Other

Very common (10% or more): Pain (e.g., tumor pain, pain in extremity, non-cardiac chest pain, flank pain, back pain, arthralgia, bone pain, cancer pain, musculoskeletal pain, myalgia, neck pain) (52%), fatigue/asthenia (47%), pyrexia (10%)

Common (1% to 10%): Sepsis^[Ref]

Renal

Very common (10% or more): Creatinine increased (14%)^[Ref]

Respiratory

Very common (10% or more): Cough/productive cough (18%), dyspnea/dyspnea exertional (16%), upper respiratory tract infection (e.g., laryngitis, nasopharyngitis, pharyngitis, rhinitis, sinusitis, upper respiratory tract infection, viral upper respiratory tract infection) (30%), lower respiratory tract infection (e.g., bronchitis, lower respiratory tract infection, tracheobronchitis) (17%)

Common (1% to 10%): Pneumonia^[Ref]